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Note F - Common Stock and Warrants (Details Textual) - USD ($) $ / shares in Units, $ in Thousands |  |  |  |  | 1 Months Ended | 3 Months Ended | 6 Months Ended | 9 Months Ended |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jan. 26, 2021 | Jan. 12, 2021 | Oct. 25, 2018 | Jun. 02, 2014 | Jan. 31, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Jun. 18, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Jun. 30, 2022 | Mar. 31, 2022 | Dec. 31, 2021 | Feb. 03, 2021 | Jan. 08, 2021 | Dec. 31, 2020
Common Stock, Shares Authorized (in shares) |  |  |  |  |  | 250,000,000 |  |  | 250,000,000 |  |  |  | 250,000,000 |  |  |
Common Stock, Shares, Issued (in shares) |  |  |  |  |  | 35,411,097 |  |  | 35,411,097 |  |  |  | 35,325,801 |  |  |
Common Stock, Shares, Outstanding, Ending Balance (in shares) |  |  |  |  |  | 34,501,144 |  |  | 34,501,144 |  | 34,489,314 | 34,423,497 | 35,005,640 |  |  |
Proceeds from Warrant Exercises |  |  |  |  |  |  |  |  | $ 0 | $ 30,819 |  |  |  |  |  |
Preferred Stock Dividends and Other Adjustments, Total |  |  |  |  |  | $ (0) | $ (0) |  | (0) | $ 54,342 |  |  |  |  |  |
Other Noncurrent Assets [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract with Customer, Asset, after Allowance for Credit Loss, Total |  |  |  |  |  | $ 400 |  |  | $ 400 |  |  |  | $ 400 |  |  |
Deerfield Warrant [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right Issued (in shares) |  |  |  | 14,423,076 |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ 46.25 |  |  |  |  |  |  | $ 38.34 |  |  |  |  |  |  |  | $ 93.60
Deerfield Warrant [Member] | Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  | 1,923,077 |  |  |  |  |  |  |  |  |  |  |  | 120,192
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ 46.25 |  |  | $ 5.85 |  |  |  | $ 38.34 |  |  |  |  |  |  |  | $ 93.60
Warrant Issued to KVK [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  | 500,000 |  |  |  |  |  |  |  |  |  |  |  |  | 31,250
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) |  |  | $ 2.30 |  |  |  |  |  |  |  |  |  |  |  |  | $ 36.80
Class of Warrant or Right, Additional Shares Exercisable for Each Milestones (in shares) |  |  | 125,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Pre-funded Warrants [Member] | Roth Capital Partners, LLC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 926,844 |  |  |  |  |  |  |  |  |  |  |  |  | 926,844 |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) |  | $ 0.0001 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Warrant Exercises (in shares) |  |  |  |  | 926,841 |  |  |  |  |  |  |  |  |  |  |
Proceeds from Warrant Exercises |  |  |  |  | $ 72,000 |  |  |  |  |  |  |  |  |  |  |
Public Offering Warrants [Member] | Roth Capital Partners, LLC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 12,078,361 |  |  |  |  |  |  |  |  |  |  |  |  | 7,692,307 |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) |  | $ 6.50 |  |  |  |  |  |  |  |  |  |  |  |  | $ 6.50 |
Stock Issued During Period, Shares, Warrant Exercises (in shares) |  |  |  |  |  |  |  |  | 3,030,881 |  |  |  |  |  |  |
Proceeds from Warrant Exercises |  |  |  |  |  |  |  |  | $ 16,900 |  |  |  |  |  |  |
Warrants and Rights Outstanding, Term (Year) |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum Percent of Common Stock Ownership Allowed Per Holder Upon Warrant Exercise |  | 4.99% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrants or Right, Exercised During Period (in shares) |  |  |  |  |  |  |  |  | 3,461,858 |  |  |  |  |  |  |
Underwriter Warrants [Member] | Roth Capital Partners, LLC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 806,932 |  |  |  |  |  |  |  |  |  |  |  | 18,702 | 754,035 |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) |  | $ 8.125 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Warrant Exercises (in shares) |  |  |  |  |  |  |  |  | 400,000 |  |  |  |  |  |  |
Proceeds from Warrant Exercises |  |  |  |  |  |  |  |  | $ 3,300 |  |  |  |  |  |  |
Class of Warrants or Right, Exercised During Period (in shares) |  |  |  |  |  |  |  |  | 400,000 |  |  |  |  |  |  |
Over Allotment Options, Percentage of Common Stock Outstanding for Warrants |  | 5.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Existing Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 6,620,358 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Warrant Exercises | $ 44,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Placement Agent Fee, Percentage | 6.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
January 2021 Inducement Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 7,944,430 |  |  |  |  |  |  | 6,117,509 |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ 6.36 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Warrant Exercises (in shares) |  |  |  |  |  |  |  |  | 1,676,921 |  |  |  |  |  |  |
Proceeds from Warrant Exercises |  |  |  |  |  |  |  | $ 39,100 | $ 10,700 |  |  |  |  |  |  |
Warrants and Rights Outstanding, Term (Year) | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum Percent of Common Stock Ownership Allowed Per Holder Upon Warrant Exercise | 4.99% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrants or Right, Exercised During Period (in shares) |  |  |  |  |  |  |  |  | 1,676,921 |  |  |  |  |  |  |
Warrants Issued Upon Exchange, Percentage of Shares Issued Upon Exercise | 120.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant, Purchase Price Per Warrant (in dollars per share) | $ 0.125 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Placement Agent Fee, Percentage |  |  |  |  |  |  |  | 6.00% |  |  |  |  |  |  |  |
Maximum Percent of Common Stock Ownership Allowed Per Holder After Warrant Exercise Upon Holders Selection | 9.99% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock Dividends and Other Adjustments, Total |  |  |  |  |  |  |  |  | $ 37,400 |  |  |  |  |  |  |
June 2021 Inducement Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  |  |  |  |  | 1,529,379 |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) |  |  |  |  |  |  |  | $ 16.50 |  |  |  |  |  |  |  |
Maximum Percent of Common Stock Ownership Allowed Per Holder Upon Warrant Exercise |  |  |  |  |  |  |  | 4.99% |  |  |  |  |  |  |  |
Class of Warrants or Right, Exercised During Period (in shares) |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |
Warrants Issued Upon Exchange, Percentage of Shares Issued Upon Exercise |  |  |  |  |  |  |  | 25.00% |  |  |  |  |  |  |  |
Class of Warrant, Purchase Price Per Warrant (in dollars per share) |  |  |  |  |  |  |  | $ 0.125 |  |  |  |  |  |  |  |
Maximum Percent of Common Stock Ownership Allowed Per Holder After Warrant Exercise Upon Holders Selection |  |  |  |  |  |  |  | 9.99% |  |  |  |  |  |  |  |
Preferred Stock Dividends and Other Adjustments, Total |  |  |  |  |  |  |  |  | $ 16,900 |  |  |  |  |  |  |

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