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Note A - Description of Business, Basis of Presentation and Significant Transactions (Details Textual) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 9 Months Ended
May 15, 2022
Jul. 12, 2021
Feb. 01, 2021
Jan. 12, 2021
Jan. 08, 2021
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Dec. 31, 2021
Dec. 20, 2021
Jul. 02, 2021
Feb. 03, 2021
Sale of Stock, Authorized Amount   $ 350,000                    
Stock Issued During Period, Value, New Issues             $ 1,105          
Stock Repurchase Program, Authorized Amount                   $ 50,000    
Treasury Stock, Value, Total           $ 7,536   $ 7,536 $ 2,814      
Share Repurchase Program [Member]                        
Treasury Stock, Shares, Total (in shares)           909,953   909,953        
Treasury Stock, Value, Total           $ 7,500   $ 7,500        
Roth Capital Partners, LLC [Member] | Pre-funded Warrants [Member]                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)       926,844 926,844              
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)       $ 0.0001                
Roth Capital Partners, LLC [Member] | Public Offering Warrants [Member]                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)       12,078,361 7,692,307              
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)       $ 6.50 $ 6.50              
Class of Warrant or Right, Offering Price, Per Related Warrant (in dollars per share)         $ 0.0001              
Roth Capital Partners, LLC [Member] | Underwriter Warrants [Member]                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)       806,932 754,035             18,702
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)       $ 8.125                
Over Allotment Options, Number of Shares for Warrants (in shares)         1,153,846              
Underwriting Agreement [Member] | Roth Capital Partners, LLC [Member]                        
Stock Issued During Period, Shares, New Issues (in shares)         6,765,463              
Shares and Warrants Issued, Price Per Share (in dollars per share)         $ 6.50              
Shares Issued, Price Per Share (in dollars per share)         $ 6.4999              
Proceeds from Issuance or Sale of Equity, Total       $ 52,400                
Over-Allotment Option [Member] | Roth Capital Partners, LLC [Member]                        
Stock Issued During Period, Shares, New Issues (in shares)     374,035                  
Purchase Agreement Optional Period to Shares (Day)         45 days              
Purchase Agreement, Maximum, Additional Shares Available for Purchase During the Optional Period (in shares)         1,153,846              
ATM Agreement Sales [Member] | JMP and RBCCM [Member]                        
Stock Issued During Period, Shares, New Issues (in shares)               0        
Equity Distribution Agreement, Maximum Aggregate Offering Price                     $ 75,000  
Equity Distribution Agreement, Commission Fee, Percentage of Gross Sales                     3.00%  
Stock Issued During Period, Value, New Issues   $ 75,000                    
Arimoclomol Purchase Agreement [Member]                        
Payments to Acquire Productive Assets, Total $ 12,800                      
Asset Acquisition, Consideration Transferred, Estimated Reserve Liability $ 5,200         6,300   $ 6,300        
Estimated Weighted Average Cost of Capital 42.00%                      
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount           $ 700   $ 700        
Arimoclomol Purchase Agreement [Member] | In Process Research and Development [Member]                        
Asset Acquisition, Recognized Identifiable Assets, Finite-Lived Intangibles [1] $ 17,663                      
[1] The primary asset acquired, the IPR&D asset, was expensed and the allocated transaction related costs were included with and expensed with this asset.