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Note F - Common Stock and Warrants (Details Textual) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 3 Months Ended 6 Months Ended 9 Months Ended
Jan. 26, 2021
Jan. 12, 2021
Oct. 25, 2018
Jun. 02, 2014
Jan. 31, 2021
Sep. 30, 2022
Sep. 30, 2021
Jun. 18, 2021
Sep. 30, 2022
Sep. 30, 2021
Jun. 30, 2022
Mar. 31, 2022
Dec. 31, 2021
Feb. 03, 2021
Jan. 08, 2021
Dec. 31, 2020
Common Stock, Shares Authorized (in shares)           250,000,000     250,000,000       250,000,000      
Common Stock, Shares, Issued (in shares)           35,411,097     35,411,097       35,325,801      
Common Stock, Shares, Outstanding, Ending Balance (in shares)           34,501,144     34,501,144   34,489,314 34,423,497 35,005,640      
Proceeds from Warrant Exercises                 $ 0 $ 30,819            
Preferred Stock Dividends and Other Adjustments, Total           $ (0) $ (0)   (0) $ 54,342            
Other Noncurrent Assets [Member]                                
Contract with Customer, Asset, after Allowance for Credit Loss, Total           $ 400     $ 400       $ 400      
Deerfield Warrant [Member]                                
Class of Warrant or Right Issued (in shares)       14,423,076                        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) $ 46.25             $ 38.34               $ 93.60
Deerfield Warrant [Member] | Common Stock [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)       1,923,077                       120,192
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) $ 46.25     $ 5.85       $ 38.34               $ 93.60
Warrant Issued to KVK [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)     500,000                         31,250
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)     $ 2.30                         $ 36.80
Class of Warrant or Right, Additional Shares Exercisable for Each Milestones (in shares)     125,000                          
Pre-funded Warrants [Member] | Roth Capital Partners, LLC [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)   926,844                         926,844  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)   $ 0.0001                            
Stock Issued During Period, Shares, Warrant Exercises (in shares)         926,841                      
Proceeds from Warrant Exercises         $ 72,000                      
Public Offering Warrants [Member] | Roth Capital Partners, LLC [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)   12,078,361                         7,692,307  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)   $ 6.50                         $ 6.50  
Stock Issued During Period, Shares, Warrant Exercises (in shares)                 3,030,881              
Proceeds from Warrant Exercises                 $ 16,900              
Warrants and Rights Outstanding, Term (Year)   5 years                            
Maximum Percent of Common Stock Ownership Allowed Per Holder Upon Warrant Exercise   4.99%                            
Class of Warrants or Right, Exercised During Period (in shares)                 3,461,858              
Underwriter Warrants [Member] | Roth Capital Partners, LLC [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)   806,932                       18,702 754,035  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)   $ 8.125                            
Stock Issued During Period, Shares, Warrant Exercises (in shares)                 400,000              
Proceeds from Warrant Exercises                 $ 3,300              
Class of Warrants or Right, Exercised During Period (in shares)                 400,000              
Over Allotment Options, Percentage of Common Stock Outstanding for Warrants   5.00%                            
Existing Warrants [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) 6,620,358                              
Proceeds from Warrant Exercises $ 44,000                              
Placement Agent Fee, Percentage 6.00%                              
January 2021 Inducement Warrants [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) 7,944,430             6,117,509                
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) $ 6.36                              
Stock Issued During Period, Shares, Warrant Exercises (in shares)                 1,676,921              
Proceeds from Warrant Exercises               $ 39,100 $ 10,700              
Warrants and Rights Outstanding, Term (Year) 5 years                              
Maximum Percent of Common Stock Ownership Allowed Per Holder Upon Warrant Exercise 4.99%                              
Class of Warrants or Right, Exercised During Period (in shares)                 1,676,921              
Warrants Issued Upon Exchange, Percentage of Shares Issued Upon Exercise 120.00%                              
Class of Warrant, Purchase Price Per Warrant (in dollars per share) $ 0.125                              
Placement Agent Fee, Percentage               6.00%                
Maximum Percent of Common Stock Ownership Allowed Per Holder After Warrant Exercise Upon Holders Selection 9.99%                              
Preferred Stock Dividends and Other Adjustments, Total                 $ 37,400              
June 2021 Inducement Warrants [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)               1,529,379                
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)               $ 16.50                
Maximum Percent of Common Stock Ownership Allowed Per Holder Upon Warrant Exercise               4.99%                
Class of Warrants or Right, Exercised During Period (in shares)                 0              
Warrants Issued Upon Exchange, Percentage of Shares Issued Upon Exercise               25.00%                
Class of Warrant, Purchase Price Per Warrant (in dollars per share)               $ 0.125                
Maximum Percent of Common Stock Ownership Allowed Per Holder After Warrant Exercise Upon Holders Selection               9.99%                
Preferred Stock Dividends and Other Adjustments, Total                 $ 16,900