In accordance with the SEC’s disclosure requirements regarding pay versus performance, or PVP, this section presents the SEC-defined “Compensation Actually Paid,” or CAP. Also required by the SEC, this section compares CAP to various measures used to gauge our performance. CAP is a supplemental measure to be viewed alongside performance measures as an addition to the philosophy and strategy of compensation-setting discussed elsewhere in the overview of the executive compensation program, not in replacement.

The following table sets forth information concerning the compensation of our named executive officers for each of the fiscal years ended December 31, 2023, 2022 and 2021, and our financial performance for each such fiscal year:

															Value of Initial Fixed $100 Investment Based on:
Year	Summary Compensation Table Total for Current PEO ($)(1)		Compensation Actually Paid to Current PEO ($)(1)		Summary Compensation Table Total for Travis Mickle, Ph.D. ($)(2)	Compensation Actually Paid to Travis Mickle, Ph.D. ($)(2)	Summary Compensation Table Total for Richard W. Pascoe ($)(3)	Compensation Actually Paid to Richard W. Pascoe ($)(3)	Summary Compensation Table Total for Christal M.M. Mickle ($)(4)	Compensation Actually Paid to Christal M.M. Mickle ($)(4)	Average Summary Compensation Table Total for Non-PEO NEOs ($)(5)		Average Compensation Actually Paid to Non-PEO NEOs ($)(5)		Total Shareholder Return ($)		Net Income ($)
2023		3,445,231		4,975,770	3,593,438	4,385,998	4,122,558	3,308,589	1,669,956	2,211,127		2,039,861		2,724,999		58.48		(46,049,000)
2022		—		—	2,400,356	1,349,703	—	—	—	—		1,199,492		1,106,040		40.98		(41,543,000)
2021		—		—	2,657,059	2,808,110	—	—	—	—		953,616		989,957		77.77		(8,555,000)

(2) Dr. Travis Mickle served as the Company’s Chief Executive Officer in 2021, 2022 and from January 1, 2023 until January 6, 2023.

(3) Mr. Pascoe served as the Company’s Chief Executive Officer from January 6, 2023, until June 1, 2023. As noted below, Mr. Pascoe also served as a non-PEO NEO during 2022 and 2021, and his compensation for those years is reflected in the columns entitled “Average Summary Compensation Table Total for Non-PEO NEOs” and “Average Compensation Actually Paid to Non-PEO NEOs.”

(4) Ms. Christal Mickle served as the Company’s Interim Chief Executive Officer from June 1, 2023, until October 10, 2023.

(5) Amounts represent the average compensation actually paid to our remaining named executive officers for the relevant fiscal year, as determined under SEC rules (and described below), which includes the individuals indicated in the table below for each fiscal year.