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Note M - Stock-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2024
Notes Tables |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Year ended December 31, |
|  | 2024 |  |  | 2023 |
Research and development |  | $ | 5,819 |  |  | $ | 2,664 |
General and administrative |  |  | 9,087 |  |  |  | 3,290 |
Total stock-based compensation expense |  | $ | 14,906 |  |  | $ | 5,954 |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Year Ended December 31, |
|  | 2024 |  |  | 2023 |
Risk-free interest rate |  |  | 3.82% - 4.50% |  |  |  | 3.34% - 4.79% |
Expected term (in years) |  |  | 5.50 - 6.25 |  |  |  | 5.50 - 10.00 |
Expected volatility |  |  | 89.85% - 91.32% |  |  |  | 89.48% - 93.67% |
Expected dividend yield |  |  | 0 |  |  |  | 0 |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  |  |  |  |  | Weighted |  |  | Weighted Avg |  |  | Aggregate |
|  | Number of |  |  | Average |  |  | Remaining |  |  | Intrinsic |
|  | Options |  |  | Exercise Price |  |  | Contractual Term |  |  | Value |
Outstanding balance at January 1, 2024 |  |  | 7,275,197 |  |  | $ | 8.40 |  |  |  | 8.68 |  |  | $ | 11,089 |
Granted |  |  | 962,700 |  |  | $ | 5.74 |  |  |  | - |  |  |  | - |
Exercised or released |  |  | 1,162,705 |  |  | $ | 5.30 |  |  |  | - |  |  | $ | 1,966 |
Canceled or forfeited |  |  | 314,250 |  |  | $ | 4.90 |  |  |  | - |  |  |  | - |
Expired |  |  | 809,542 |  |  | $ | 22.52 |  |  |  | - |  |  |  | - |
Outstanding balance at December 31, 2024 |  |  | 5,951,400 |  |  | $ | 7.25 |  |  |  | 6.79 |  |  | $ | 17,448 |
Exercisable at December 31, 2024 |  |  | 2,399,305 |  |  | $ | 10.25 |  |  |  | 4.47 |  |  | $ | 6,302 |
Vested and expected to vest at December 31, 2024 |  |  | 5,764,166 |  |  |  |  |  |  |  | 6.75 |  |  | $ | 16,783 |
Share-Based Payment Arrangement, Option, Exercise Price Range [Table Text Block] |
|  | Options Outstanding |  |  | Options Exercisable |
|  |  |  |  |  | Weighted Avg |  |  |  |  |  |  | Weighted Avg |
|  | Number of |  |  | Remaining |  |  | Number of |  |  | Remaining |
Exercise Price |  | Shares |  |  | Contractual Term |  |  | Shares |  |  | Contractual Term |
$2.848 to $10.00 |  | 5,841,257 |  |  | 6.91 |  |  | 2,289,162 |  |  | 4.69 |
$10.01 to $30.00 |  | 1,875 |  |  | 4.31 |  |  | 1,875 |  |  | 4.37 |
$30.01 to $50.00 |  | 39,218 |  |  | 2.67 |  |  | 39,218 |  |  | 2.71 |
$50.01 to $70.00 |  | 21,958 |  |  | 1.60 |  |  | 21,958 |  |  | 1.63 |
$70.01 to $327.20 |  | 47,092 |  |  | 1.36 |  |  | 47,092 |  |  | 8.34 |
|  |  | 5,951,400 |  |  |  |  |  |  |  | 2,399,305 |  |  |  |  |
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] |
|  | Number of Unvested Shares |
|  | December 31, |
Exercise Price |  | 2024 |  |  | 2023 |
$2.848 to $10.00 |  |  | 3,552,095 |  |  |  | 5,614,977 |
Total number of unvested stock options |  |  | 3,552,095 |  |  |  | 5,614,977 |
Restricted Stock Units (RSUs) [Member] |
Notes Tables |
Schedule of Unvested Restricted Stock Units Roll Forward [Table Text Block] |
|  | Shares |  |  | Weighted-average grant date fair value |
Unvested balance at December 31, 2023 |  |  | 747,945 |  |  | $ | 4.33 |
Granted |  |  | 2,012,958 |  |  |  | 5.52 |
Vested |  |  | 765,945 |  |  |  | 4.77 |
Forfeited |  |  | 156,700 |  |  |  | 5.83 |
Unvested balance at December 31, 2024 |  |  | 1,838,258 |  |  | $ | 5.32 |
As of December 31, 2024 there was $7.1 million of total unrecognized compensation cost related to restricted stock units.

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