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Note M - Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2024

Notes Tables

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		Year ended December 31,
		2024				2023
Research and development		$	5,819			$	2,664
General and administrative			9,087				3,290
Total stock-based compensation expense		$	14,906			$	5,954

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		Year Ended December 31,
		2024				2023
Risk-free interest rate			3.82% - 4.50%				3.34% - 4.79%
Expected term (in years)			5.50 - 6.25				5.50 - 10.00
Expected volatility			89.85% - 91.32%				89.48% - 93.67%
Expected dividend yield			0				0

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

						Weighted				Weighted Avg				Aggregate
		Number of				Average				Remaining				Intrinsic
		Options				Exercise Price				Contractual Term				Value
Outstanding balance at January 1, 2024			7,275,197			$	8.40				8.68			$	11,089
Granted			962,700			$	5.74				-				-
Exercised or released			1,162,705			$	5.30				-			$	1,966
Canceled or forfeited			314,250			$	4.90				-				-
Expired			809,542			$	22.52				-				-
Outstanding balance at December 31, 2024			5,951,400			$	7.25				6.79			$	17,448
Exercisable at December 31, 2024			2,399,305			$	10.25				4.47			$	6,302
Vested and expected to vest at December 31, 2024			5,764,166								6.75			$	16,783

Share-Based Payment Arrangement, Option, Exercise Price Range [Table Text Block]

		Options Outstanding								Options Exercisable
						Weighted Avg								Weighted Avg
		Number of				Remaining				Number of				Remaining
Exercise Price		Shares				Contractual Term				Shares				Contractual Term
$2.848 to $10.00		5,841,257				6.91				2,289,162				4.69
$10.01 to $30.00		1,875				4.31				1,875				4.37
$30.01 to $50.00		39,218				2.67				39,218				2.71
$50.01 to $70.00		21,958				1.60				21,958				1.63
$70.01 to $327.20		47,092				1.36				47,092				8.34
			5,951,400								2,399,305

Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]

		Number of Unvested Shares
		December 31,
Exercise Price		2024				2023
$2.848 to $10.00			3,552,095				5,614,977
Total number of unvested stock options			3,552,095				5,614,977

Restricted Stock Units (RSUs) [Member]

Notes Tables

Schedule of Unvested Restricted Stock Units Roll Forward [Table Text Block]

		Shares				Weighted-average grant date fair value
Unvested balance at December 31, 2023			747,945			$	4.33
Granted			2,012,958				5.52
Vested			765,945				4.77
Forfeited			156,700				5.83
Unvested balance at December 31, 2024			1,838,258			$	5.32

As of December 31, 2024 there was $7.1 million of total unrecognized compensation cost related to restricted stock units. 

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