<SUBMISSION>
<ACCESSION-NUMBER>0001062822-03-000006
<TYPE>3
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20031201
<FILING-DATE>20031210
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>SCHAFER CAROL
<CIK>0001272181
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>3
<ACT>34
<FILE-NUMBER>000-30111
<FILM-NUMBER>031047145
</FILING-VALUES>
<MAIL-ADDRESS>
<STREET1>8800 TECHNOLOGY FOREST PLACAE
<CITY>WOODLANDS
<STATE>TX
<ZIP>77381
</MAIL-ADDRESS>
</REPORTING-OWNER>
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>LEXICON GENETICS INC/TX
<CIK>0001062822
<ASSIGNED-SIC>2835
<IRS-NUMBER>760474169
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>8800 TECHNOLOGY FOREST PLACE
<CITY>THE WOODLANDS
<STATE>TX
<ZIP>77381
<PHONE>2818633000
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>8800 TECHNOLOGY FOREST PLACE
<CITY>THE WOODLANDS
<STATE>TX
<ZIP>77381
</MAIL-ADDRESS>
</ISSUER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>sch177.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>
    <schemaVersion>X0201</schemaVersion>

    <documentType>3</documentType>
	<periodOfReport>2003-12-01</periodOfReport>
    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001062822</issuerCik>
        <issuerName>LEXICON GENETICS INC/TX</issuerName>
        <issuerTradingSymbol>LEXG</issuerTradingSymbol>
	</issuer>
	<reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001272181</rptOwnerCik>
            <rptOwnerName>SCHAFER CAROL</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>8800 TECHNOLOGY FOREST PLACE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>THE WOODLANDS</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>773811160</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
			<isDirector>0</isDirector>
			<isOfficer>1</isOfficer>
			<isTenPercentOwner>0</isTenPercentOwner>
			<isOther>0</isOther>
			<officerTitle>VP Finance - Communications</officerTitle>
		</reportingOwnerRelationship>
	</reportingOwner>
	<nonDerivativeTable>
		<nonDerivativeHolding>
			<securityTitle>
				<value>Common Stock</value>
			</securityTitle>
			<postTransactionAmounts>
				<sharesOwnedFollowingTransaction>
					<value>1000</value>
				</sharesOwnedFollowingTransaction>
			</postTransactionAmounts>
			<ownershipNature>
				<directOrIndirectOwnership>
					<value>D</value>
				</directOrIndirectOwnership>
				<natureOfOwnership>
					<value/>
				</natureOfOwnership>
			</ownershipNature>
		</nonDerivativeHolding>
	</nonDerivativeTable>
	<derivativeTable>
		<derivativeHolding>
			<securityTitle>
				<value>Employee Stock Option (right to buy)</value>
			</securityTitle>
			<conversionOrExercisePrice>
				<value>5.25</value>
			</conversionOrExercisePrice>
			<exerciseDate>
				<footnoteId id="F1"/>
			</exerciseDate>
			<expirationDate>
				<value>2013-12-01</value>
			</expirationDate>
			<underlyingSecurity>
				<underlyingSecurityTitle>
					<value>Common Stock</value>
				</underlyingSecurityTitle>
				<underlyingSecurityShares>
					<value>60000.00</value>
				</underlyingSecurityShares>
			</underlyingSecurity>
			<ownershipNature>
				<directOrIndirectOwnership>
					<value>D</value>
				</directOrIndirectOwnership>
				<natureOfOwnership>
					<value/>
				</natureOfOwnership>
			</ownershipNature>
		</derivativeHolding>
	</derivativeTable>
	<footnotes>
		<footnote id="F1">Option vests with respect to 25% of the shares subject to the option on the first anniversary of employment (12/1/2004) and vests 1/48th per month for each month of service thereafter.</footnote>
	</footnotes>
	<remarks>
	</remarks>
	<ownerSignature>
		<signatureName>/s/ Schafer, Carol </signatureName>
		<signatureDate>2003-12-10</signatureDate>
	</ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
