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<SEC-DOCUMENT>0001062822-09-000025.txt : 20090313
<SEC-HEADER>0001062822-09-000025.hdr.sgml : 20090313
<ACCEPTANCE-DATETIME>20090313083001
ACCESSION NUMBER:		0001062822-09-000025
CONFORMED SUBMISSION TYPE:	DEFA14A
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20090313
DATE AS OF CHANGE:		20090313
EFFECTIVENESS DATE:		20090313

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC./DE
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEFA14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		09677427

	BUSINESS ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEFA14A
<SEQUENCE>1
<FILENAME>proxy2009.htm
<DESCRIPTION>LEXICON PHARMACEUTICALS DEFA14A 4-23-2009
<TEXT>
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  <head>
    <title>proxy2009.htm</title>
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              <hr style="COLOR: black" align="left" noshade size="1" width="100%">
            </div>
            <div>&#160;</div>
            <div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">UNITED
STATES</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">SECURITIES
AND EXCHANGE COMMISSION</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Washington,
DC. 20549</font></div>
              <div style="DISPLAY: block; TEXT-INDENT: 0pt"><br></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">SCHEDULE
14A</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">(Rule
14A-101)</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">INFORMATION
REQUIRED IN PROXY STATEMENT</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">SCHEDULE
14A INFORMATION</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
              <div align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Proxy
Statement Pursuant to Section&#160;14(a) of</font></div>
              <div align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">the
Securities Exchange Act of 1934</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><font style="FONT-SIZE: 8pt">Filed by the Registrant <font size="+0">x</font></font><a name="Check10" /></font></div>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><font style="FONT-SIZE: 8pt">Filed by a Party other than the Registrant </font><a name="Check11" /></font></div>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Check the
appropriate box:</font></div>
              <div>
                <table cellpadding="0" cellspacing="0" width="100%">
                    <tr>
                      <td align="left" valign="top" width="2%" style="TEXT-ALIGN: right">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: right" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: wingdings">o</font></div>
                      </td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="46%">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: -25.2pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="FONT-SIZE: 8pt">Preliminary Proxy Statement</font></font></div>
                      </td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;<font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: wingdings">o</font></font></td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="46%">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: -25.2pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><a name="check5"><font style="FONT-SIZE: 8pt">Confidential, for Use of the
      Commission Only</font></a></font></div>
                      </td>
                    </tr>
                    <tr>
                      <td align="left" valign="top" width="2%" style="TEXT-ALIGN: right"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman"><font size="2" style="DISPLAY: inline; FONT-FAMILY: wingdings">o</font></font></td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="46%">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: -25.2pt; TEXT-ALIGN: left" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="FONT-SIZE: 8pt">Definitive Proxy Statement</font></font></div>
                      </td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="46%">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(as
      permitted by Rule 14a-6(e)(2))</font></div>
                      </td>
                    </tr>
                    <tr>
                      <td align="left" valign="top" width="2%">
                        <div style="TEXT-ALIGN: right"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;<font size="3">x</font>&#160; </font></div>
                      </td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="46%">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: -25.2pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><a name="check3"><font style="FONT-SIZE: 8pt">Definitive Additional
      Materials</font></a></font></div>
                      </td>
                      <td valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td valign="top" width="46%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;
      </font></td>
                    </tr>
                    <tr>
                      <td align="left" valign="top" width="2%">
                        <div style="TEXT-ALIGN: right"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;<font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: wingdings">o</font></font></div>
                      </td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="46%">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: -25.2pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><a name="check4"><font style="FONT-SIZE: 8pt">Soliciting Material Pursuant to
      Rule&#160;14a-11(c) </font></a></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="FONT-SIZE: 8pt">or Rule&#160;14a-12</font></font></div>
                      </td>
                      <td valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td valign="top" width="46%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;
      </font></td>
                    </tr>
                </table>
              </div>
              <div style="DISPLAY: block; TEXT-INDENT: 0pt">&#160;</div>
              <div style="DISPLAY: block; TEXT-INDENT: 0pt">
              </div>
              <div>&#160;</div>
              <div align="center">
                <table bgcolor="white" cellpadding="0" cellspacing="0" width="100%">
                    <tr>
                      <td width="100%">
                        <div style="TEXT-ALIGN: center"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;<font style="FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: times new roman">LEXICON
      PHARMACEUTICALS, INC.</font></font></div>
                      </td>
                    </tr>
                    <tr>
                      <td width="100%" style="BORDER-TOP: black 1px solid">
                        <div style="TEXT-ALIGN: center"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;<font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(<font style="FONT-SIZE: 8pt">Name <font size="+0" style="FONT-SIZE: 8pt">o</font>f<font size="+0" style="FONT-SIZE: 8pt"> <font size="+0" style="FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Registrant</font></font></font><font> as</font> Specified In Its
      Charter)</font></font></div>
                      </td>
                    </tr>
                    <tr>
                      <td width="100%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    </tr>
                    <tr>
                      <td width="100%" style="BORDER-TOP: black 1px solid">
                        <div style="TEXT-ALIGN: center"><font style="FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;(Name of
      Person(s) Filing Proxy Statement, if Other Than the
      Registrant)</font></div>
                      </td>
                    </tr>
                </table>
              </div>
              <div>&#160;</div>
              <div style="DISPLAY: block; TEXT-INDENT: 0pt"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Payment of
Filing Fee (Check the appropriate box):</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
              <div>
                <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">
                    <tr valign="top">
                      <td style="WIDTH: 27pt"><font style="FONT-SIZE: 8pt">&#160;<font size="+0">x</font></font></td>
                      <td>
                        <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">No
      fee required.</font></div>
                      </td>
                    </tr>
                </table>
              </div>
              <div>
                <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">
                    <tr valign="top">
                      <td style="WIDTH: 27pt"><font style="FONT-SIZE: 8pt"><font style="DISPLAY: inline; FONT-SIZE: 10pt;" face="Wingdings">o</font></font></td>
                      <td>
                        <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Fee
      <font style="FONT-SIZE: 8pt">computed <font size="+0" style="FONT-SIZE: 8pt">on</font> table</font> below per Exchange Act
      Rules&#160;14a-6(i)(1) and 0-11.<font id="TAB2" style="LETTER-SPACING: 9pt">&#160;</font></font></div>
                      </td>
                    </tr>
                </table>
              </div>
              <div>&#160;</div>
              <div>
                <div style="DISPLAY: block; TEXT-INDENT: 0pt">
                  <div>
                    <table cellpadding="0" cellspacing="0" width="100%">
                        <tr>
                          <td align="left" valign="top" width="4%" style="BORDER-TOP: medium none; BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                          <td align="left" valign="top" width="3%" style="BORDER-TOP: medium none; BORDER-BOTTOM: black">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(1)</font></div>
                          </td>
                          <td align="left" valign="top" width="70%" style="BORDER-TOP: medium none; BORDER-BOTTOM: black">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Title
      of each class of securities to which transaction
      applies:&#160;&#160;N/A</font></div>
                          </td>
                        </tr>
                        <tr>
                          <td align="left" valign="top" width="4%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                          <td align="left" valign="top" width="3%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(2)</font></div>
                          </td>
                          <td align="left" valign="top" width="70%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Aggregate
      number of securities to which transaction
      applies:&#160;&#160;N/A</font></div>
                          </td>
                        </tr>
                        <tr>
                          <td align="left" valign="top" width="4%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                          <td align="left" valign="top" width="3%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(3)</font></div>
                          </td>
                          <td align="left" valign="top" width="70%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Per
      unit price or other underlying value of transaction computed pursuant to
      Exchange Act Rule 0-11 (set forth the amount on which the filing fee is
      calculated and state how it was
      determined):&#160;&#160;N/A&#160;</font></div>
                          </td>
                        </tr>
                        <tr>
                          <td align="left" valign="top" width="4%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                          <td align="left" valign="top" width="3%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(4)</font></div>
                          </td>
                          <td align="left" valign="top" width="70%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Proposed
      maximum aggregate value of transaction:&#160;&#160;N/A</font></div>
                          </td>
                        </tr>
                        <tr>
                          <td align="left" valign="top" width="4%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                          <td align="left" valign="top" width="3%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(5)</font></div>
                          </td>
                          <td align="left" valign="top" width="70%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Total
      fee paid:&#160;&#160;$0</font></div>
                          </td>
                        </tr>
                    </table>
                  </div>
                </div>
              </div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">
                <div align="center">
                  <table border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%">
                      <tr valign="top">
                        <td style="WIDTH: 27pt"><font style="FONT-SIZE: 8pt">&#160;<font style="DISPLAY: inline; FONT-SIZE: 10pt;" face="Wingdings">o</font></font></td>
                        <td><a name="check8"><font style="FONT-SIZE: 8pt">Fee paid previously with
      preliminary materials:&#160;&#160;N/A</font></a></td>
                      </tr>
                      <tr valign="top">
                        <td style="WIDTH: 27pt"><font style="FONT-SIZE: 8pt">&#160;<font style="DISPLAY: inline; FONT-SIZE: 10pt;" face="Wingdings">o</font></font></td>
                        <td><font style="FONT-SIZE: 8pt"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Check
      box if any part of the fee is offset as provided by Exchange Act
      Rule&#160;0-11(a)(2) and identify the filing for which the offsetting fee
      was paid previously. Identify the previous filing by registration
      statement number, or the Form or Schedule and the date of its
      filing.</font></font></td>
                      </tr>
                  </table>
                </div>
                <div align="center">
                </div>
                <div>&#160;</div>
                <div>
                  <div>&#160;</div>
                  <div>
                    <div style="DISPLAY: block; TEXT-INDENT: 0pt">
                      <div>
                        <table cellpadding="0" cellspacing="0" width="100%">
                            <tr>
                              <td align="left" valign="top" width="4%" style="BORDER-TOP: medium none; BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                              <td align="left" valign="top" width="3%" style="BORDER-TOP: medium none; BORDER-BOTTOM: black">
                                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(1)</font></div>
                              </td>
                              <td align="left" valign="top" width="70%" style="BORDER-TOP: medium none; BORDER-BOTTOM: black">
                                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Amount
      Previously Paid:</font></div>
                              </td>
                            </tr>
                            <tr>
                              <td align="left" valign="top" width="4%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                              <td align="left" valign="top" width="3%">
                                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(2)</font></div>
                              </td>
                              <td align="left" valign="top" width="70%"><font size="2" style="FONT-SIZE: 8pt">Form, Schedule or Registration Statement No.:</font></td>
                            </tr>
                            <tr>
                              <td align="left" valign="top" width="4%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                              <td align="left" valign="top" width="3%">
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                              <td align="left" valign="top" width="70%"><font size="2" style="FONT-SIZE: 8pt">Filing Party:</font></td>
                            </tr>
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      Filed</font></div>
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                        </table>
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                                                                                                                                      <td colspan="2" rowspan="3" valign="top" width="47%" style="BORDER-BOTTOM: black 1px solid">
                                                                                                                                        <div align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-STYLE: italic; FONT-FAMILY: arial">LEXICON
      PHARMACEUTICALS, INC.</font></div>
                                                                                                                                        <div align="center"><font style="FONT-FAMILY: arial"><font style="FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-SIZE: 9pt"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">**IMPORTANT
      NOTICE**</font> </font></font></font></div>
                                                                                                                                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 13.7pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">Regarding
      the Availability of Proxy Materials</font></div>
                                                                                                                                      </td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td colspan="4" valign="top" width="52%" style="BORDER-BOTTOM: black 1px solid">
                                                                                                                                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 13.7pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">Shareholder
      Meeting to be held on 04/23/09</font></div>
                                                                                                                                      </td>
                                                                                                                                    </tr>
                                                                                                                                    <tr>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td colspan="4" valign="top" width="52%">
                                                                                                                                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 13.7pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">Proxy
      Materials Available</font></div>
                                                                                                                                      </td>
                                                                                                                                    </tr>
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                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td align="left" valign="top" width="3%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;*&#160;&#160;</font></td>
                                                                                                                                      <td align="left" colspan="3" valign="top" width="49%">
                                                                                                                                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 13.7pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">Notice and
      Proxy Statement</font></div>
                                                                                                                                      </td>
                                                                                                                                    </tr>
                                                                                                                                    <tr>
                                                                                                                                      <td colspan="2" valign="top" width="47%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td valign="top" width="3%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;*</font></td>
                                                                                                                                      <td colspan="3" valign="top" width="49%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: times new roman"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">Annual
      Report</font></font></font></font></font></td>
                                                                                                                                    </tr>
                                                                                                                                    <tr>
                                                                                                                                      <td colspan="2" rowspan="3" valign="top" width="47%" style="TEXT-ALIGN: justify">
                                                                                                                                        <div><font size="+0"><font size="+0"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">You are
      receiving this communication because you hold shares in the
      above&#160;</font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">company, and
      the materials<font size="+0" style="FONT-SIZE: 9pt"> you</font> should
      review before you cast your vote are now </font><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">available.</font></font></font></div>
                                                                                                                                      </td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td colspan="4" valign="top" width="52%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                    </tr>
                                                                                                                                    <tr>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td colspan="4" valign="top" width="52%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                    </tr>
                                                                                                                                    <tr>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td align="left" colspan="4" valign="top" width="52%" style="BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 5pt; BORDER-TOP: black 1px solid; PADDING-LEFT: 5pt; BORDER-LEFT: black 1px solid; PADDING-TOP: 5pt"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial; TEXT-DECORATION: underline">PROXY
      MATERIALS - VIEW OR RECEIVE</font></td>
                                                                                                                                    </tr>
                                                                                                                                    <tr>
                                                                                                                                      <td colspan="2" valign="top" width="47%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td align="left" colspan="4" rowspan="2" valign="top" width="52%" style="BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 5pt; PADDING-LEFT: 5pt; PADDING-BOTTOM: 5pt; BORDER-LEFT: black 1px solid; BORDER-BOTTOM: black 1px solid">
                                                                                                                                        <div style="TEXT-ALIGN: justify" align="left"><font size="+0"><font size="+0"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">You
      can choose to view the materials online or receive a paper or e-mail
      copy.&#160; There is NO charge for requesting a copy.&#160; Requests,
      instructions and other inquiries will NOT be forwarded to your investment
      advisor.</font><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></font></font></div>
                                                                                                                                        <div style="TEXT-ALIGN: justify" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-SIZE: 9pt"><font style="FONT-WEIGHT: bold; FONT-SIZE: 9pt">To
      facilitate timely delivery please make the request as instructed
      below&#160;on or before
    04/09/09.</font>&#160;</font></font></font></div>
                                                                                                                                      </td>
                                                                                                                                    </tr>
                                                                                                                                    <tr>
                                                                                                                                      <td colspan="2" valign="top" width="47%" style="TEXT-ALIGN: justify"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">This
      communication presents only an overview of the more complete proxy
      materials that are available to you on the Internet.&#160; We encourage
      you to access and review all of the important information contained in the
      proxy materials before voting.</font></td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;
    </font></td>
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                                                                                                                                      <td colspan="2" valign="top" width="47%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td colspan="4" valign="top" width="52%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                    </tr>
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                                                                                                                                      <td colspan="2" valign="top" width="47%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td align="left" colspan="4" valign="top" width="52%" style="BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 5pt; BORDER-TOP: black 1px solid; PADDING-LEFT: 5pt; BORDER-LEFT: black 1px solid; PADDING-TOP: 5pt"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial; TEXT-DECORATION: underline">HOW
      TO VIEW MATERIALS VIA THE INTERNET</font></font></font></td>
                                                                                                                                    </tr>
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                                                                                                                                      <td colspan="2" valign="top" width="47%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                                                                                                                                      <td align="left" colspan="4" valign="top" width="52%" style="BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 5pt; PADDING-LEFT: 5pt; PADDING-BOTTOM: 5pt; BORDER-LEFT: black 1px solid; BORDER-BOTTOM: black 1px solid"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">Have the 12
      Digit Control Number available and visit:&#160;
  www.proxyvote.com</font></td>
                                                                                                                                    </tr>
                                                                                                                                    <tr>
                                                                                                                                      <td align="left" rowspan="2" valign="top" width="8%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                      <td align="left" rowspan="2" valign="top" width="39%">
                                                                                                                                        <div><font style="DISPLAY: inline; FONT-SIZE: 6pt; FONT-FAMILY: arial">LEXICON
      PHARMACEUTICALS, INC</font></div>
                                                                                                                                        <div><font size="2" style="FONT-SIZE: 6pt">8800 TECHNOLOGY FOREST
      PLACE</font></div>
                                                                                                                                        <div><font size="2" style="FONT-SIZE: 6pt">THE WOODLANDS, TX&#160;
      77381-4287</font></div>
                                                                                                                                      </td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;</font></td>
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                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                      <td align="left" colspan="4" valign="top" width="52%" style="BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 5pt; BORDER-TOP: black 1px solid; PADDING-LEFT: 5pt; BORDER-LEFT: black 1px solid; PADDING-TOP: 5pt"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-WEIGHT: bold; FONT-SIZE: 9pt; TEXT-DECORATION: underline">HOW
      TO REQUEST A COPY OF MATERIALS</font></font></font></td>
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                                                                                                                                      <td colspan="2" valign="top" width="47%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                      <td align="left" valign="top" width="3%" style="PADDING-LEFT: 5pt; BORDER-LEFT: black 1px solid"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">1)</font></td>
                                                                                                                                      <td valign="top" width="16%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;BY
      INTERNET</font></td>
                                                                                                                                      <td valign="top" width="3%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-SIZE: 9pt">&#160;<font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: times new roman">&#8211;</font></font></font></font></td>
                                                                                                                                      <td align="left" valign="top" width="30%" style="BORDER-RIGHT: black 1px solid"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;www.proxyvote.com</font></td>
                                                                                                                                    </tr>
                                                                                                                                    <tr>
                                                                                                                                      <td colspan="2" valign="top" width="47%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                      <td align="left" valign="top" width="3%" style="PADDING-LEFT: 5pt; BORDER-LEFT: black 1px solid"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">2)</font></td>
                                                                                                                                      <td valign="top" width="16%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;BY
      TELEPHONE</font></td>
                                                                                                                                      <td valign="top" width="3%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-SIZE: 9pt">&#160;<font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: times new roman">&#8211;</font></font></font></font></td>
                                                                                                                                      <td align="left" valign="top" width="30%" style="BORDER-RIGHT: black 1px solid"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;1-800-579-1639</font></td>
                                                                                                                                    </tr>
                                                                                                                                    <tr>
                                                                                                                                      <td colspan="2" valign="top" width="47%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                      <td align="left" valign="top" width="3%" style="PADDING-LEFT: 5pt; BORDER-LEFT: black 1px solid"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">3)</font></td>
                                                                                                                                      <td valign="top" width="16%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;BY
      E-MAIL*</font></td>
                                                                                                                                      <td valign="top" width="3%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-SIZE: 9pt">&#160;<font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: times new roman">&#8211;</font></font></font></font></td>
                                                                                                                                      <td align="left" valign="top" width="30%" style="BORDER-RIGHT: black 1px solid"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;sendmaterial@proxyvote.com</font></td>
                                                                                                                                    </tr>
                                                                                                                                    <tr>
                                                                                                                                      <td colspan="2" valign="top" width="47%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                      <td align="left" colspan="4" valign="top" width="52%" style="BORDER-RIGHT: black 1px solid; PADDING-RIGHT: 5pt; PADDING-LEFT: 5pt; PADDING-BOTTOM: 5pt; BORDER-LEFT: black 1px solid; BORDER-BOTTOM: black 1px solid"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">*If requesting
      materials by e-mail, please send a blank e-mail with the 12 Digit Control
      Number (located on the following page) in the subject line.</font></td>
                                                                                                                                    </tr>
                                                                                                                                    <tr>
                                                                                                                                      <td colspan="2" valign="top" width="47%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                      <td valign="top" width="1%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                      <td colspan="4" valign="top" width="52%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;</font></td>
                                                                                                                                    </tr>
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                                                    </div>
                                                  </div>
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the Reverse Side for Meeting Information and Instructions on How to
Vote</font></div>
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          <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left">&#160;</div>
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            <div align="left">
              <div align="left">
                <div align="left">
                  <div align="left">
                    <div align="left">
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                          <tr>
                            <td colspan="2" valign="top" width="37%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: arial"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: times new roman"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">MEETING
      INFORMATION</font></font></font></font></font></td>
                            <td valign="top" width="12%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: times new roman">&#160;
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                            <td align="left" colspan="2" valign="top" width="51%">
                              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">HOW
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                          </tr>
                          <tr>
                            <td colspan="2" valign="top" width="37%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: times new roman">&#160;
      </font></td>
                            <td valign="top" width="12%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: times new roman">&#160;
      </font></td>
                            <td colspan="2" valign="top" width="51%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: times new roman">&#160;
      </font></td>
                          </tr>
                          <tr>
                            <td rowspan="2" valign="top" width="14%">
                              <div><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">Meeting
      Type:</font></div>
                              <div><font size="2" style="FONT-SIZE: 9pt; FONT-FAMILY: arial">Meeting
      Date:</font></div>
                              <div><font size="2" style="FONT-SIZE: 9pt; FONT-FAMILY: arial">Meeting
      Time:</font></div>
                              <div><font size="2" style="FONT-SIZE: 9pt; FONT-FAMILY: arial">For holders
      as of:</font></div>
                            </td>
                            <td rowspan="2" valign="top" width="23%">
                              <div><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">Annual</font></div>
                              <div><font size="2" style="FONT-SIZE: 9pt; FONT-FAMILY: arial">04/23/09</font></div>
                              <div><font size="2" style="FONT-SIZE: 9pt; FONT-FAMILY: arial">1:30 PM
      CDT</font></div>
                              <div><font size="2" style="FONT-SIZE: 9pt; FONT-FAMILY: arial">02/23/09</font></div>
                            </td>
                            <td valign="top" width="12%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;
      </font></td>
                            <td align="left" valign="top" width="12%" style="BORDER-RIGHT: black 2px solid; BORDER-TOP: black 2px solid; BORDER-LEFT: black 2px solid; BORDER-BOTTOM: black 2px solid">
                              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: center" align="left"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;<font style="FONT-SIZE: 9pt; FONT-FAMILY: arial"> <font style="FONT-SIZE: 9pt; FONT-FAMILY: arial">Vote In
      Person</font></font>&#160; </font></div>
                            </td>
                            <td align="left" valign="top" width="39%">
                              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
                            </td>
                          </tr>
                          <tr>
                            <td valign="top" width="12%">
                              <div style="TEXT-ALIGN: center"><img src="logo2.jpg" alt=""></div>
                            </td>
                            <td align="left" colspan="2" valign="top" width="51%" style="PADDING-TOP: 5pt">
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      stockholder meetings have attendance requirements including, but not
      limited to, the possession of an attendance ticket issued by the entity
      holding the meeting.&#160; Please check the meeting materials for any
      special requirements for meeting attendance.&#160; At the Meeting you will
      need to request a ballot to vote these shares.</font></div>
                            </td>
                          </tr>
                          <tr>
                            <td colspan="2" valign="top" width="37%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;
      </font></td>
                            <td valign="top" width="12%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;
      </font></td>
                            <td colspan="2" valign="top" width="51%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;
      </font></td>
                          </tr>
                          <tr>
                            <td colspan="2" valign="top" width="37%">
                              <div><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">MEETING
      LOCATION:</font></div>
                            </td>
                            <td valign="top" width="12%"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
    </font></td>
                            <td align="left" nowrap valign="top" width="12%" style="BORDER-RIGHT: black 2px solid; BORDER-TOP: black 2px solid; BORDER-LEFT: black 2px solid; BORDER-BOTTOM: black 2px solid">
                              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;<font style="FONT-SIZE: 9pt; FONT-FAMILY: arial"> <font style="FONT-SIZE: 9pt; FONT-FAMILY: arial">Vote By
      Internet</font></font>&#160; </font></div>
                            </td>
                            <td align="left" valign="top" width="39%">
                              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left">&#160;</div>
                            </td>
                          </tr>
                          <tr>
                            <td colspan="2" valign="top" width="37%">
                              <div><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">THE
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                              <div><font size="2" style="FONT-SIZE: 9pt; FONT-FAMILY: arial">CONVENTION
      CENTER</font></div>
                              <div><font size="2" style="FONT-SIZE: 9pt; FONT-FAMILY: arial">1601 LAKE
      ROBBINS DRIVE</font></div>
                              <div><font size="2" style="FONT-SIZE: 9pt; FONT-FAMILY: arial">THE
      WOODLANDS, TX&#160; 77381</font></div>
                            </td>
                            <td valign="top" width="12%">
                              <div style="TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><img src="logo1.jpg" alt=""></font></div>
                            </td>
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                              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: justify" align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">To vote <font size="+0" style="FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-STYLE: italic; FONT-FAMILY: arial">now</font>
      </font>by Internet, go to <font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial; TEXT-DECORATION: underline">WWW.PROXYVOTE.COM</font>.
      Use the Internet to transmit your voting instructions and for electronic
      delivery of information up until 11:59 P.M. Eastern Time the day before
      the cut-off date or meeting date. Have your notice in hand when you access
      the web site and follow the
instructions.</font></div>
                            </td>
                          </tr>
                      </table>
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                </div>
              </div>
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          <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;
</font></div>
          <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left">
            <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
              <div id="FTR">
                <div id="GLFTR" style="WIDTH: 100%" align="left">
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              <div id="PN" style="PAGE-BREAK-AFTER: always">
                <div style="WIDTH: 100%; TEXT-ALIGN: center">
                </div>
                <div style="WIDTH: 100%; TEXT-ALIGN: center">
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                <tr>
                  <td align="left" width="31%" style="BORDER-RIGHT: black 2px solid; BORDER-TOP: black 2px solid; BORDER-LEFT: black 2px solid; BORDER-BOTTOM: black 2px solid">
                    <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: center" align="left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="FONT-SIZE: 10pt">&#160;<font size="+0">&#160;<font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-SIZE: 9pt; FONT-FAMILY: arial">Voting&#160;&#160;items</font>&#160;
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BOARD OF DIRECTORS RECOMMENDS A VOTE &#8220;FOR&#8221;&#160;&#160;ITEMS&#160;1, 2, 3 and
4.</font></div>
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      CLASS III DIRECTORS</font></div>
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                </tr>
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          <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">Nominees:</font></div>
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                  <td style="WIDTH: 36pt">
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                    <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">01)</font></div>
                  </td>
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                    <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">Arthur T.
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                </tr>
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          <div>
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                    <td width="94%"><font style="FONT-SIZE: 9pt; FONT-FAMILY: arial">Approval
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                  </tr>
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                    <td width="6%"><font style="FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></td>
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                    <td width="94%"><font style="FONT-SIZE: 9pt; FONT-FAMILY: arial">Approval
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                  </tr>
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                    <td width="6%"><font style="FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></td>
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                    <td width="94%"><font style="FONT-SIZE: 9pt; FONT-FAMILY: arial">Ratification and approval of
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                    <td width="94%"><font style="FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;In
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      the meeting or any adjournment of adjournments
  thereof.</font></td>
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