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<SEC-DOCUMENT>0001062822-10-000024.txt : 20100319
<SEC-HEADER>0001062822-10-000024.hdr.sgml : 20100319
<ACCEPTANCE-DATETIME>20100319160754
ACCESSION NUMBER:		0001062822-10-000024
CONFORMED SUBMISSION TYPE:	DEFA14A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20100319
DATE AS OF CHANGE:		20100319
EFFECTIVENESS DATE:		20100319

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC./DE
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEFA14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		10694332

	BUSINESS ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEFA14A
<SEQUENCE>1
<FILENAME>proxynotice2010.htm
<TEXT>
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<head>
    <title>proxynotice2010.htm</title>
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              <hr style="COLOR: black" align="left" noshade size="1" width="100%">
            </div>
            <div>&#160;</div>
            <div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">UNITED
STATES</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">SECURITIES
AND EXCHANGE COMMISSION</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Washington,
DC. 20549</font></div>
              <div style="DISPLAY: block; TEXT-INDENT: 0pt"><br></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">SCHEDULE
14A</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">(Rule
14A-101)</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">INFORMATION
REQUIRED IN PROXY STATEMENT</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">SCHEDULE
14A INFORMATION</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
              <div align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">Proxy
Statement Pursuant to Section&#160;14(a) of</font></div>
              <div align="center"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: Times New Roman">the
Securities Exchange Act of 1934</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><font style="FONT-SIZE: 8pt">Filed by the Registrant x</font><a name="Check10" /></font></div>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><font style="FONT-SIZE: 8pt">Filed by a Party other than the Registrant </font><a name="Check11" /></font></div>
              <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Check the
appropriate box:</font></div>
              <div>
                <table cellpadding="0" cellspacing="0" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr>
                      <td align="left" valign="top" width="2%" style="TEXT-ALIGN: right">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: right" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: wingdings">o</font></div>
                      </td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="46%">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: -25.2pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="FONT-SIZE: 8pt">Preliminary Proxy Statement</font></font></div>
                      </td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;<font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: wingdings">o</font></font></td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="46%">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: -25.2pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><a name="check5"><font style="FONT-SIZE: 8pt">Confidential, for Use of the
      Commission Only</font></a></font></div>
                      </td>
                    </tr><tr>
                      <td align="left" valign="top" width="2%" style="TEXT-ALIGN: right"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman"><font size="2" style="DISPLAY: inline; FONT-FAMILY: wingdings">o</font></font></td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="46%">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: -25.2pt; TEXT-ALIGN: left" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="FONT-SIZE: 8pt">Definitive Proxy Statement</font></font></div>
                      </td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="46%">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(as
      permitted by Rule 14a-6(e)(2))</font></div>
                      </td>
                    </tr><tr>
                      <td align="left" valign="top" width="2%">
                        <div style="TEXT-ALIGN: right"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;<font size="3">x</font></font></div>
                      </td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="46%">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: -25.2pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><a name="check3"><font style="FONT-SIZE: 8pt">Definitive Additional
      Materials</font></a></font></div>
                      </td>
                      <td valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td valign="top" width="46%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;
      </font></td>
                    </tr><tr>
                      <td align="left" valign="top" width="2%">
                        <div style="TEXT-ALIGN: right"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;<font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: wingdings">o</font></font></div>
                      </td>
                      <td align="left" valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td align="left" valign="top" width="46%">
                        <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: -25.2pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><a name="check4"><font style="FONT-SIZE: 8pt">Soliciting Material Pursuant to
      Rule&#160;14a-11(c) </font></a></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="FONT-SIZE: 8pt">or Rule&#160;14a-12</font></font></div>
                      </td>
                      <td valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td valign="top" width="2%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                      <td valign="top" width="46%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;
      </font></td>
                    </tr></table>
              </div>
              <div style="DISPLAY: block; TEXT-INDENT: 0pt">&#160;</div>
              <div style="DISPLAY: block; TEXT-INDENT: 0pt">
              </div>
              <div>&#160;</div>
              <div align="center">
                <table bgcolor="white" cellpadding="0" cellspacing="0" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr>
                      <td width="100%">
                        <div style="TEXT-ALIGN: center"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;<font style="FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: times new roman">LEXICON
      PHARMACEUTICALS, INC.</font></font></div>
                      </td>
                    </tr><tr>
                      <td width="100%" style="BORDER-TOP: black 1px solid">
                        <div style="TEXT-ALIGN: center"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;<font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(<font style="FONT-SIZE: 8pt">Name <font style="FONT-SIZE: 8pt">o</font>f<font style="FONT-SIZE: 8pt"> <font style="FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Registrant</font></font></font>
      as Specified In Its Charter)</font></font></div>
                      </td>
                    </tr><tr>
                      <td width="100%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    </tr><tr>
                      <td width="100%" style="BORDER-TOP: black 1px solid">
                        <div style="TEXT-ALIGN: center"><font style="FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;(Name of
      Person(s) Filing Proxy Statement, if Other Than the
      Registrant)</font></div>
                      </td>
                    </tr></table>
              </div>
              <div>&#160;</div>
              <div style="DISPLAY: block; TEXT-INDENT: 0pt"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Payment of
Filing Fee (Check the appropriate box):</font></div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
              <div>
                <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr valign="top">
                      <td style="WIDTH: 27pt"><font style="FONT-SIZE: 8pt">&#160;x</font></td>
                      <td>
                        <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">No
      fee required.</font></div>
                      </td>
                    </tr></table>
              </div>
              <div>
                <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr valign="top">
                      <td style="WIDTH: 27pt"><font style="FONT-SIZE: 8pt"><font style="DISPLAY: inline; FONT-SIZE: 10pt;" face="Wingdings">o</font></font></td>
                      <td>
                        <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Fee
      <font style="FONT-SIZE: 8pt">computed <font style="FONT-SIZE: 8pt">on</font> table</font> below per Exchange Act
      Rules&#160;14a-6(i)(1) and 0-11.<font id="TAB2" style="LETTER-SPACING: 9pt">&#160;</font></font></div>
                      </td>
                    </tr></table>
              </div>
              <div>&#160;</div>
              <div>
                <div style="DISPLAY: block; TEXT-INDENT: 0pt">
                  <div>
                    <table cellpadding="0" cellspacing="0" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr>
                          <td align="left" valign="top" width="4%" style="BORDER-TOP: medium none; BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                          <td align="left" valign="top" width="3%" style="BORDER-TOP: medium none; BORDER-BOTTOM: black">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(1)</font></div>
                          </td>
                          <td align="left" valign="top" width="70%" style="BORDER-TOP: medium none; BORDER-BOTTOM: black">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Title
      of each class of securities to which transaction
      applies:&#160;&#160;N/A</font></div>
                          </td>
                        </tr><tr>
                          <td align="left" valign="top" width="4%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                          <td align="left" valign="top" width="3%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(2)</font></div>
                          </td>
                          <td align="left" valign="top" width="70%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Aggregate
      number of securities to which transaction
      applies:&#160;&#160;N/A</font></div>
                          </td>
                        </tr><tr>
                          <td align="left" valign="top" width="4%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                          <td align="left" valign="top" width="3%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(3)</font></div>
                          </td>
                          <td align="left" valign="top" width="70%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Per
      unit price or other underlying value of transaction computed pursuant to
      Exchange Act Rule 0-11 (set forth the amount on which the filing fee is
      calculated and state how it was
      determined):&#160;&#160;N/A&#160;</font></div>
                          </td>
                        </tr><tr>
                          <td align="left" valign="top" width="4%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                          <td align="left" valign="top" width="3%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(4)</font></div>
                          </td>
                          <td align="left" valign="top" width="70%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Proposed
      maximum aggregate value of transaction:&#160;&#160;N/A</font></div>
                          </td>
                        </tr><tr>
                          <td align="left" valign="top" width="4%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                          <td align="left" valign="top" width="3%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(5)</font></div>
                          </td>
                          <td align="left" valign="top" width="70%">
                            <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Total
      fee paid:&#160;&#160;$0</font></div>
                          </td>
                        </tr></table>
                  </div>
                </div>
              </div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify">
                <div align="center">
                  <table border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr valign="top">
                        <td style="WIDTH: 27pt"><font style="FONT-SIZE: 8pt">&#160;<font style="DISPLAY: inline; FONT-SIZE: 10pt;" face="Wingdings">o</font></font></td>
                        <td><a name="check8"><font style="FONT-SIZE: 8pt">Fee paid previously with
      preliminary materials:&#160;&#160;N/A</font></a></td>
                      </tr><tr valign="top">
                        <td style="WIDTH: 27pt"><font style="FONT-SIZE: 8pt">&#160;<font style="DISPLAY: inline; FONT-SIZE: 10pt;" face="Wingdings">o</font></font></td>
                        <td><font style="FONT-SIZE: 8pt"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Check
      box if any part of the fee is offset as provided by Exchange Act
      Rule&#160;0-11(a)(2) and identify the filing for which the offsetting fee
      was paid previously. Identify the previous filing by registration
      statement number, or the Form or Schedule and the date of its
      filing.</font></font></td>
                      </tr></table>
                </div>
                <div align="center">
                </div>
                <div>&#160;</div>
                <div>
                  <div>&#160;</div>
                  <div>
                    <div style="DISPLAY: block; TEXT-INDENT: 0pt">
                      <div>
                        <table cellpadding="0" cellspacing="0" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr>
                              <td align="left" valign="top" width="4%" style="BORDER-TOP: medium none; BORDER-BOTTOM: black"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                              <td align="left" valign="top" width="3%" style="BORDER-TOP: medium none; BORDER-BOTTOM: black">
                                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(1)</font></div>
                              </td>
                              <td align="left" valign="top" width="70%" style="BORDER-TOP: medium none; BORDER-BOTTOM: black">
                                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">Amount
      Previously Paid:</font></div>
                              </td>
                            </tr><tr>
                              <td align="left" valign="top" width="4%"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">&#160;</font></td>
                              <td align="left" valign="top" width="3%">
                                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 8pt; FONT-FAMILY: times new roman">(2)</font></div>
                              </td>
                              <td align="left" valign="top" width="70%"><font size="2" style="FONT-SIZE: 8pt">Form, Schedule or Registration Statement No.:</font></td>
                            </tr><tr>
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                              </td>
                            </tr></table>
                      </div>
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                </div>
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          <div>&#160;</div>
          <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
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            <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left">&#160;</div>
            <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left">
            </div>
            <div>&#160;</div>
            <div align="center">
              <table bgcolor="white" cellpadding="0" cellspacing="0" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr>
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                      <div><font style="FONT-WEIGHT: bold; FONT-SIZE: 16pt; FONT-FAMILY: times new roman">***
      Exercise Your <font style="FONT-STYLE: italic">Right</font> to Vote
      ***</font></div>
                      <div><font style="FONT-SIZE: 13pt; FONT-FAMILY: arial"><font style="FONT-WEIGHT: bold">IMPORTANT NOTICE</font> Regarding the
      Availability of Proxy Materials</font></div>
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                    <td colspan="2" width="43%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td width="9%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
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                    <td colspan="2" width="43%"><font style="FONT-WEIGHT: bold; FONT-SIZE: 11pt; FONT-FAMILY: arial">&#160;</font></td>
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                    <td colspan="2" width="40%" style="BORDER-RIGHT: black 1pt solid; TEXT-ALIGN: left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;Lexicon
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                    <td colspan="2" width="43%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;</font></td>
                    <td width="9%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;</font></td>
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                    <td colspan="2" width="43%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;</font></td>
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                    <td colspan="2" width="40%" style="BORDER-RIGHT: black 1pt solid; TEXT-ALIGN: left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;The
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                    <td width="1%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
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                    <td colspan="2" width="43%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td width="9%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
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                    <td colspan="2" width="43%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td width="9%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td width="1%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
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                      <div><font style="DISPLAY: inline; FONT-SIZE: 6pt; FONT-FAMILY: arial">LEXICON
      PHARMACEUTICALS, INC</font></div>
                      <div><font size="2" style="FONT-SIZE: 6pt">8800 TECHNOLOGY FOREST
      PLACE</font></div>
                      <div><font size="2" style="FONT-SIZE: 6pt">THE WOODLANDS, TX&#160;
      77381-4287</font></div>
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                    <td width="1%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td colspan="3" width="47%" style="TEXT-ALIGN: justify"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">This is not a ballot.&#160;
      You cannot use this notice to vote these shares.&#160; This communication
      presents only an overview of the more complete proxy materials that are
      available to you on the Internet.&#160; You may view the proxy materials
      online at <font style="FONT-STYLE: italic">www.proxyvote.com</font> or
      easily request a paper copy (see reverse side)</font></td>
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                    <td colspan="2" width="43%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td width="9%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td width="1%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
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                    <td colspan="2" width="43%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
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                    <td colspan="2" width="43%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td width="9%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td width="1%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td colspan="3" width="47%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
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                    <td colspan="2" width="43%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td width="9%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td width="1%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
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                      <div><font color="white" style="FONT-SIZE: 10pt; FONT-FAMILY: arial"><font color="white" style="FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: arial">See the reverse side of this notice </font></font></div>
                      <div><font color="white" style="FONT-SIZE: 10pt; FONT-FAMILY: arial"><font color="white" style="FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: arial">to obtain proxy materials and voting
      instructions.</font></font></div>
                    </td>
                  </tr><tr>
                    <td colspan="2" width="43%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td width="9%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td width="1%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                    <td colspan="3" width="47%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                  </tr></table>
            </div>
            <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left">&#160;</div>
            <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
              <div id="FTR">
                <div id="GLFTR" style="WIDTH: 100%" align="left">
                </div>
              </div>
              <div id="PN" style="PAGE-BREAK-AFTER: always">
                <div style="WIDTH: 100%; TEXT-ALIGN: center">
                </div>
                <div style="WIDTH: 100%; TEXT-ALIGN: center">
                  <hr style="COLOR: black" noshade size="2">
                </div>
              </div>
              <div id="HDR">
                <div id="GLHDR" style="WIDTH: 100%" align="right">
                </div>
              </div>
            </div>
            <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left">&#160;</div>
            <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left">
              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left">&#160;</div>
              <div>
                <div align="left">
                  <div align="left">
                    <div align="left">
                      <div align="left">
                        <div align="left">
                          <table cellpadding="0" cellspacing="0" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr>
                                <td colspan="2" valign="top" width="51%" style="TEXT-ALIGN: center">
                                  <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 16pt; FONT-FAMILY: arial"><font style="FONT-SIZE: 16pt"><font style="DISPLAY: inline; FONT-SIZE: 16pt; FONT-FAMILY: times new roman">&#8212;</font>&#160;BEFORE
      YOU VOTE <font style="DISPLAY: inline; FONT-SIZE: 16pt; FONT-FAMILY: times new roman">&#8212;</font></font></font></div>
                                </td>
                              </tr><tr>
                                <td colspan="2" valign="top" width="51%" style="TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-WEIGHT: normal; FONT-SIZE: 13pt; FONT-FAMILY: arial">&#160;How
      to Access the Proxy Materials</font></td>
                              </tr></table>
                          <div>&#160;</div>
                          <div>
                          </div>
                          <div>&#160;</div>
                          <div align="center">
                            <table bgcolor="white" cellpadding="0" cellspacing="0" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr>
                                  <td colspan="4" width="99%" style="BORDER-TOP: black 1pt solid; BORDER-LEFT: black 1pt solid"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">&#160;</font></td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid; BORDER-TOP: black 1pt solid"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                                </tr><tr>
                                  <td width="1%" style="BORDER-LEFT: black 1pt solid">&#160;</td>
                                  <td colspan="3" width="98%" style="PADDING-BOTTOM: 2pt; PADDING-TOP: 2pt; TEXT-ALIGN: left"><font style="FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: arial">Proxy
      Materials Available to VIEW or RECEIVE:</font></td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid">&#160;</td>
                                </tr><tr>
                                  <td width="1%" style="BORDER-LEFT: black 1pt solid">&#160;</td>
                                  <td colspan="2" width="24%" style="PADDING-BOTTOM: 2pt; PADDING-TOP: 2pt; TEXT-ALIGN: left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">1.
      Notice &amp; Proxy Statement</font></td>
                                  <td width="74%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">2.
      Annual Report</font></td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid">&#160;</td>
                                </tr><tr>
                                  <td width="1%" style="BORDER-LEFT: black 1pt solid">&#160;</td>
                                  <td colspan="3" width="98%" style="PADDING-BOTTOM: 2pt; PADDING-TOP: 2pt; TEXT-ALIGN: left"><font style="FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: arial">How to View
      Online:</font></td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid">&#160;</td>
                                </tr><tr>
                                  <td width="1%" style="BORDER-LEFT: black 1pt solid">&#160;</td>
                                  <td colspan="3" width="98%" style="PADDING-BOTTOM: 2pt; PADDING-TOP: 2pt; TEXT-ALIGN: left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">Have the 12-Digit Control
      Number available (located on the following page) and visit: <font style="FONT-STYLE: italic">www.proxyvote.com</font></font></td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid">&#160;</td>
                                </tr><tr>
                                  <td width="1%" style="BORDER-LEFT: black 1pt solid">&#160;</td>
                                  <td colspan="3" width="98%" style="PADDING-BOTTOM: 2pt; PADDING-TOP: 2pt; TEXT-ALIGN: left"><font style="FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: arial">How to
      Request and Receive a PAPER or E-MAIL Copy:</font></td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid">&#160;</td>
                                </tr><tr>
                                  <td width="1%" style="BORDER-LEFT: black 1pt solid">&#160;</td>
                                  <td colspan="3" width="98%" style="PADDING-BOTTOM: 2pt; PADDING-TOP: 2pt; TEXT-ALIGN: left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">If
      you want to receive a paper or e-mail copy of these documents, you must
      request one. There is NO charge for requesting a copy. Please choose one
      of the following methods to make your request:</font></td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid">&#160;</td>
                                </tr><tr>
                                  <td width="1%" style="BORDER-LEFT: black 1pt solid">&#160;</td>
                                  <td width="7%" style="PADDING-BOTTOM: 1pt; PADDING-TOP: 2pt; TEXT-ALIGN: left">&#160;</td>
                                  <td width="17%" style="PADDING-BOTTOM: 1pt; PADDING-TOP: 2pt; TEXT-ALIGN: left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">1) BY
      INTERNET:</font></td>
                                  <td width="74%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">www.proxyvote.com</font></td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid">&#160;</td>
                                </tr><tr>
                                  <td width="1%" style="BORDER-LEFT: black 1pt solid">&#160;</td>
                                  <td width="7%" style="PADDING-BOTTOM: 1pt; PADDING-TOP: 1pt; TEXT-ALIGN: left">&#160;</td>
                                  <td width="17%" style="PADDING-BOTTOM: 1pt; PADDING-TOP: 1pt; TEXT-ALIGN: left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">2) BY
      TELEPHONE:</font></td>
                                  <td width="74%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">1-800-579-1639</font></td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid">&#160;</td>
                                </tr><tr>
                                  <td width="1%" style="BORDER-LEFT: black 1pt solid">&#160;</td>
                                  <td width="7%" style="PADDING-BOTTOM: 2pt; PADDING-TOP: 1pt; TEXT-ALIGN: left">&#160;</td>
                                  <td width="17%" style="PADDING-BOTTOM: 2pt; PADDING-TOP: 1pt; TEXT-ALIGN: left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">3) BY
      EMAIL*:</font></td>
                                  <td width="74%" style="PADDING-BOTTOM: 2pt; PADDING-TOP: 1pt; TEXT-ALIGN: left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">sendmaterials@proxyvote.com</font></td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid">&#160;</td>
                                </tr><tr>
                                  <td width="1%" style="BORDER-LEFT: black 1pt solid">&#160;</td>
                                  <td colspan="3" width="98%" style="PADDING-BOTTOM: 2pt; PADDING-TOP: 2pt; TEXT-ALIGN: left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">*
      If requesting materials by e-mail, please send a blank e-mail with the
      12-Digit Control Number (located on the following page) in the subject
      line.</font></td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid">&#160;</td>
                                </tr><tr>
                                  <td width="1%" style="BORDER-LEFT: black 1pt solid">&#160;</td>
                                  <td colspan="3" width="98%" style="PADDING-BOTTOM: 2pt; PADDING-TOP: 2pt; TEXT-ALIGN: left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: arial">Requests, instructions and
      other inquiries sent to this e-mail address will NOT be forwarded to your
      investment advisor. Please make the request as instructed above on or
      before April 15, 2010 to facilitate timely delivery.</font></td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid">&#160;</td>
                                </tr><tr>
                                  <td width="1%" style="BORDER-LEFT: black 1pt solid; BORDER-BOTTOM: black 1pt solid">&#160;</td>
                                  <td colspan="3" width="98%" style="BORDER-BOTTOM: black 1pt solid">&#160;</td>
                                  <td width="1%" style="BORDER-RIGHT: black 1pt solid; BORDER-BOTTOM: black 1pt solid">&#160;</td>
                                </tr></table>
                          </div>
                          <div>&#160;</div>
                          <div>&#160;</div>
                        </div>
                      </div>
                    </div>
                  </div>
                </div>
              </div>
            </div>
            <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left">&#160;</div>
          </div>
          <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left">&#160;</div>
          <div>
            <div align="left">
              <div align="left">
                <div align="left">
                  <div align="left">
                    <div align="left">
                      <table cellpadding="0" cellspacing="0" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr>
                            <td colspan="2" valign="top" width="51%" style="TEXT-ALIGN: center">
                              <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 16pt; FONT-FAMILY: arial"><font style="FONT-SIZE: 16pt"><font style="DISPLAY: inline; FONT-SIZE: 16pt; FONT-FAMILY: times new roman">&#8212;</font>&#160;HOW
      TO VOTE <font style="DISPLAY: inline; FONT-SIZE: 16pt; FONT-FAMILY: times new roman">&#8212;</font></font></font></div>
                            </td>
                          </tr><tr>
                            <td colspan="2" valign="top" width="51%" style="TEXT-ALIGN: center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 13pt; FONT-FAMILY: arial">&#160;<font style="FONT-WEIGHT: normal">Please Choose One of The Following Voting
      Methods</font></font></td>
                          </tr></table>
                      <div>&#160;</div>
                      <div align="left">
                        <table cellpadding="0" cellspacing="0" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr>
                              <td valign="top" width="51%" style="BORDER-RIGHT: black 1pt solid; PADDING-RIGHT: 7pt; BORDER-TOP: black 1pt solid; PADDING-LEFT: 5pt; BORDER-LEFT: black 1pt solid; PADDING-TOP: 10pt; TEXT-ALIGN: justify">
                                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-WEIGHT: bold">Vote in Person:</font>&#160; Many shareholder
      meetings have attendance requirements including, but not limited to, the
      possession of an attendance ticket issued by the entity holding the
      meeting.&#160; Please check the meeting materials for any special
      requirements for meeting attendance.&#160; At the Meeting you will need to
      request a ballot to vote these shares.</font></div>
                              </td>
                            </tr><tr>
                              <td valign="top" width="51%" style="BORDER-RIGHT: black 1pt solid; BORDER-LEFT: black 1pt solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;
      </font></td>
                            </tr><tr>
                              <td valign="top" width="51%" style="BORDER-RIGHT: black 1pt solid; PADDING-RIGHT: 5pt; PADDING-LEFT: 5pt; BORDER-LEFT: black 1pt solid; PADDING-TOP: 5pt; TEXT-ALIGN: justify">
                                <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-WEIGHT: bold">Vote by Internet:&#160; </font><font style="FONT-WEIGHT: normal">To vote <font style="FONT-WEIGHT: normal; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-WEIGHT: normal; FONT-SIZE: 9pt; FONT-STYLE: normal; FONT-FAMILY: arial">now</font>
      </font>by Internet, go to <font style="DISPLAY: inline; FONT-WEIGHT: normal; FONT-SIZE: 9pt; FONT-STYLE: italic; FONT-FAMILY: arial">www.proxyvote.com</font>.&#160;
      Have the 12&#160;Digit Control Number available and follow the
      instructions.</font></font></div>
                              </td>
                            </tr><tr>
                              <td valign="top" width="51%" style="BORDER-RIGHT: black 1pt solid; BORDER-LEFT: black 1pt solid; TEXT-ALIGN: left"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></td>
                            </tr><tr>
                              <td valign="top" width="51%" style="BORDER-RIGHT: black 1pt solid; PADDING-RIGHT: 5pt; PADDING-LEFT: 5pt; PADDING-BOTTOM: 10pt; BORDER-LEFT: black 1pt solid; PADDING-TOP: 5pt; BORDER-BOTTOM: black 1pt solid; TEXT-ALIGN: left"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;Vote
      by Mail:&#160; <font style="FONT-WEIGHT: normal">You can vote by mail by
      requesting a paper copy of the materials, which will include a proxy
      card.</font></font></td>
                            </tr></table>
                      </div>
                    </div>
                  </div>
                </div>
              </div>
            </div>
          </div>
          <div><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;
</font></div>
          <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left">
            <div id="PGBRK" style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt">
              <div id="FTR">
                <div id="GLFTR" style="WIDTH: 100%" align="left">
                </div>
              </div>
              <div id="PN" style="PAGE-BREAK-AFTER: always">
                <div style="WIDTH: 100%; TEXT-ALIGN: center">
                </div>
                <div style="WIDTH: 100%; TEXT-ALIGN: center">
                  <hr style="COLOR: black" noshade size="2">
                </div>
              </div>
              <div id="HDR">
                <div id="GLHDR" style="WIDTH: 100%" align="right">
                </div>
              </div>
            </div>
          </div>
          <div>
          </div>
          <div style="DISPLAY: block; TEXT-INDENT: 0pt"><br></div>
          <div align="center">
            <table bgcolor="white" cellpadding="0" cellspacing="0" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr>
                  <td align="left" width="31%" style="BORDER-RIGHT: black 2px solid; BORDER-TOP: black 2px solid; BORDER-LEFT: black 2px solid; BORDER-BOTTOM: black 2px solid">
                    <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: center" align="left"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="FONT-SIZE: 10pt">&#160;&#160;<font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial"><font style="FONT-SIZE: 9pt; FONT-FAMILY: arial">Voting&#160;&#160;items</font></font></font></font></font></div>
                  </td>
                  <td width="69%"><font style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman">&#160;</font></td>
                </tr></table>
          </div>
          <div>&#160;</div>
          <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">The
Board of Directors recommends that you&#160;vote FOR&#160;the
following.</font></div>
          <div style="DISPLAY: block; TEXT-INDENT: 0pt">&#160;</div>
          <div>
            <table align="center" border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr valign="top">
                  <td style="WIDTH: 36pt">
                    <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">1.</font></div>
                  </td>
                  <td>
                    <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">Election of
      Directors</font></div>
                  </td>
                </tr></table>
          </div>
          <div style="DISPLAY: block; MARGIN-LEFT: 36pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: arial">Nominees:</font></div>
          <div align="center">
            <table border="0" cellpadding="0" cellspacing="0" id="hangingindent" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr valign="top">
                  <td style="WIDTH: 47px">
                    <div><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;
      </font></div>
                  </td>
                  <td style="WIDTH: 169px">
                    <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">01)&#160;
      Raymond Debbane</font></div>
                  </td>
                  <td width="205"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;02)&#160;
      Robert J. Lefkowitz, MD</font></td>
                  <td width="576"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;03) Alan
      S. Nies, MD</font></td>
                  <td width="113">
                    <div align="left"><font style="DISPLAY: inline; FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;</font></div>
                  </td>
                </tr></table>
          </div>
          <div align="center">
          </div>
          <div align="center">
          </div>
          <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left">&#160;</div>
          <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left"><font style="FONT-WEIGHT: bold; FONT-SIZE: 9pt; FONT-FAMILY: Arial">The Board of
Directors recommneds you vote FOR the following proposal(s):</font></div>
          <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: left">&#160;</div>
          <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left">
            <div align="center">
              <table bgcolor="white" cellpadding="0" cellspacing="0" width="100%" style="FONT-SIZE: 10pt; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">
<tr>
                    <td valign="top" width="4%"><font style="FONT-SIZE: 9pt; FONT-FAMILY: arial">&#160;4.</font></td>
                    <td width="96%"><font style="FONT-SIZE: 9pt; FONT-FAMILY: arial">Ratification and approval of
      the appointment of Ernst &amp; Young LLP as the Company's independent
      auditors for the fiscal year ending December&#160;31,
  2010.</font></td>
                  </tr></table>
            </div>
            <div>&#160;</div>
          </div>
          <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="FONT-SIZE: 9pt; FONT-FAMILY: Arial"><font style="FONT-WEIGHT: bold">NOTE:</font>&#160; In their discretion, upon such
other matters that may properly come before the meeting or any adjournment or
adjournments thereof.</font></div>
        </div>
        <div>&#160;</div>
      </div>
    </div>
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