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Consolidated Statements of Operations (Unaudited) (USD $) In Thousands, except Per Share data	3 Months Ended		9 Months Ended
	Sep. 30, 2011	Sep. 30, 2010	Sep. 30, 2011	Sep. 30, 2010
Revenues:
Collaborative research	$ 335	$ 632	$ 1,312	$ 3,437
Subscription and license fees	20	149	194	218
Total revenues	355	781	1,506	3,655
Operating expenses:
Research and development, including stock-based compensation of $823, $751, $2,480 and $2,366, respectively	19,655	18,941	63,721	60,268
Increase in fair value of Symphony Icon, Inc. purchase liability	2,336	1,145	5,198	1,145
General and administrative, including stock-based compensation of $609, $582, $1,874 and $1,592, respectively	4,055	4,948	13,340	15,535
Total operating expenses	26,046	25,034	82,259	76,948
Loss from operations	(25,691)	(24,253)	(80,753)	(73,293)
Gain on investments, net	0	0	0	141
Interest income	60	51	215	468
Interest expense	(560)	(637)	(1,977)	(2,093)
Other income (expense), net	88	(2,700)	145	(4,025)
Consolidated net loss before taxes	(26,103)	(27,539)	(82,370)	(78,802)
Income tax benefit	0	26	0	26
Consolidated net loss	$ (26,103)	$ (27,513)	$ (82,370)	$ (78,776)
Consolidated net loss per common share, basic and diluted	$ (0.08)	$ (0.08)	$ (0.24)	$ (0.27)
Shares used in computing consolidated net loss per common share, basic and diluted	337,678	337,404	337,625	291,196

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This item represents the change in fair value of the Symphony Icon, Inc. purchase liability. In connection with the acquisition of Symphony Icon, Lexicon made an initial estimate of the fair value of the liability for the associated based and contingent payments. Changes in this liability, based on the development of the programs and the time until such payments are expected to be made, are recorded in Lexicon's consolidated statements of operations.

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