<SEC-DOCUMENT>0001209191-11-063163.txt : 20111227
<SEC-HEADER>0001209191-11-063163.hdr.sgml : 20111226
<ACCEPTANCE-DATETIME>20111227172600
ACCESSION NUMBER:		0001209191-11-063163
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20111222
FILED AS OF DATE:		20111227
DATE AS OF CHANGE:		20111227

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DEBBANE RAYMOND
		CENTRAL INDEX KEY:			0001053890

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		111282712

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC./DE
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus Public Equities Advisors, LLC
		CENTRAL INDEX KEY:			0001340096

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		111282713

	BUSINESS ADDRESS:	
		STREET 1:		135 EAST 57TH STREET, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212-317-7520

	MAIL ADDRESS:	
		STREET 1:		135 EAST 57TH STREET, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus Public Equities, LP
		CENTRAL INDEX KEY:			0001340097

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		111282709

	BUSINESS ADDRESS:	
		STREET 1:		135 EAST 57, 30 TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212-317-7520

	MAIL ADDRESS:	
		STREET 1:		135 EAST 57, 30 TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Ulys, LLC
		CENTRAL INDEX KEY:			0001340098
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		111282711

	BUSINESS ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212-3177520

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus, CV
		CENTRAL INDEX KEY:			0001378005
		STATE OF INCORPORATION:			P7
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		111282715

	BUSINESS ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		(212) 371-1717

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus Advisors, L.L.C.
		CENTRAL INDEX KEY:			0001404553

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		111282714

	BUSINESS ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, L.L.C.
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212 371 1717

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, L.L.C.
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus, L.P.
		CENTRAL INDEX KEY:			0001404570

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		111282710

	BUSINESS ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, L.L.C.
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212 371 1717

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, L.L.C.
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
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    <reportingOwner>
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    <nonDerivativeTable>
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            </securityTitle>
            <transactionDate>
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            <transactionCoding>
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        </nonDerivativeTransaction>
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    <derivativeTable>
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                <value>2011-12-22</value>
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                <underlyingSecurityTitle>
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                <directOrIndirectOwnership>
                    <value>I</value>
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                <natureOfOwnership>
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    <footnotes>
        <footnote id="F1">On December 22, 2011, Invus, L.P. acquired 113,382,063 shares of common stock of Lexicon Pharmaceuticals, Inc. (the &quot;Issuer&quot;) from the Issuer pursuant to the exercise of subscription rights entitling the holder thereof to purchase 0.427175 shares of Issuer common stock per right and additional unsubscribed shares under certain circumstances at a subscription price of $1.13 per share.</footnote>
        <footnote id="F2">244,818,843 of the reported shares of Issuer common stock are owned directly by Invus, L.P. and 5,553,292 of the reported shares of Issuer common stock are owned directly by Invus Public Equities, L.P. and subject to a voting agreement pursuant to which Invus Public Equities, L.P. agreed to vote its shares of Issuer common stock at the sole direction of Invus, L.P. Invus Advisors, L.L.C. is the general partner of Invus, L.P. Ulys, L.L.C. is the managing member of Invus Advisors, L.L.C. Raymond Debbane is the sole member of Ulys, L.L.C. Accordingly, each of Invus Advisors, L.L.C, Ulys, L.L.C. and Raymond Debbane may be deemed to be indirect beneficial owners of the reported securities. Each of Invus Advisors, L.L.C., Ulys, L.L.C and Raymond Debbane disclaims beneficial ownership of such securities, except to the extent of its or his pecuniary interest therein.</footnote>
        <footnote id="F3">On December 22, 2011, Invus Public Equities, L.P. acquired 1,622,184 shares of Issuer common stock from the Issuer pursuant to the exercise of subscription rights entitling the holder thereof to purchase 0.427175 shares of Issuer common stock per right and additional unsubscribed shares under certain circumstances at a subscription price of $1.13 per share.</footnote>
        <footnote id="F4">131,436,780 of the reported subscription rights were owned directly by Invus, L.P., 29,782,609 of the reported subscription rights were owned directly Invus C.V. and 3,891,108 of the reported subscription rights were owned directly by Invus Public Equities, L.P.</footnote>
    </footnotes>

    <remarks>For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, Invus, L.P., Invus Public Equities, L.P., Invus C.V.,
Invus Advisors, L.L.C., Invus Public Equities Advisors, LLC and Ulys, L.L.C. may be deemed to be directors by deputization by virtue
of the right of Invus, L.P. and Invus C.V. to designate certain members of the Issuer's board of directors pursuant to a stockholders'
agreement between the Issuer and Invus, L.P.</remarks>

    <ownerSignature>
        <signatureName>INVUS, L.P., By: INVUS ADVISORS, L.L.C., its general partner, By:  /s/ Raymond Debbane, Name:   Raymond Debbane, Title:   President</signatureName>
        <signatureDate>2011-12-27</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>INVUS PUBLIC EQUITIES, L.P., By: INVUS PUBLIC EQUITIES ADVISORS, LLC, its general partner, By:  /s/ Raymond Debbane, Name:   Raymond Debbane, Title:   President</signatureName>
        <signatureDate>2011-12-27</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>INVUS C.V., By: ULYS, L.L.C., its general partner, By:  /s/ Raymond Debbane, Name:   Raymond Debbane, Title:   President</signatureName>
        <signatureDate>2011-12-27</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>INVUS ADVISORS, L.L.C., By:  /s/ Raymond Debbane, Name:   Raymond Debbane, Title:   President</signatureName>
        <signatureDate>2011-12-27</signatureDate>
    </ownerSignature>

    <ownerSignature>
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