-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 GdgGTMSJE4n+dBwOAULhtUDEwUwbADHCHlMGziWHihVGBhOCcyOKnj2vhD0AUYHa
 90fvGMfcp+tfH/D9i+c29g==

<SEC-DOCUMENT>0001445305-11-000144.txt : 20110128
<SEC-HEADER>0001445305-11-000144.hdr.sgml : 20110128
<ACCEPTANCE-DATETIME>20110128164208
ACCESSION NUMBER:		0001445305-11-000144
CONFORMED SUBMISSION TYPE:	RW
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20110128
DATE AS OF CHANGE:		20110128

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC./DE
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		RW
		SEC ACT:		
		SEC FILE NUMBER:	333-168677
		FILM NUMBER:		11556377

	BUSINESS ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
<DOCUMENT>
<TYPE>RW
<SEQUENCE>1
<FILENAME>lxrx012811rw.htm
<DESCRIPTION>REGISTRATION WITHDRAWAL
<TEXT>
<html>
	<head>
		<!-- Document created using WebFilings 22825 -->
		<!-- Copyright 2008-2011 WebFilings LLC. All Rights Reserved -->
		<title>WebFilings | EDGAR view</title>
	</head>
	<body style="font-family:Times New Roman;font-size:10pt;">
<a name="s84C233435773F22E47A2C89D5D33AEA7"></a><div><div style="line-height:120%;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div></div><br><div style="line-height:120%;text-align:left;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div><div style="line-height:120%;text-align:left;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div><div style="line-height:120%;text-align:center;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">[LEXICON PHARMACEUTICALS, INC. LETTERHEAD]</font></div><div style="line-height:120%;text-align:left;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div><div style="line-height:120%;padding-bottom:16px;text-align:center;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">January 28, 2011</font></div><div style="line-height:120%;text-align:left;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div><div style="line-height:120%;text-align:left;font-size:11pt;"><f
ont style="font-family:inherit;font-size:11pt;">Securities and Exchange Commission</font></div><div style="line-height:120%;text-align:left;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">Division of Corporate Finance</font></div><div style="line-height:120%;text-align:left;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">100 F Street, N.E.</font></div><div style="line-height:120%;text-align:left;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">Washington, D.C. 20549</font></div><div style="line-height:120%;text-align:left;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div><div style="line-height:120%;text-align:left;"><div style="padding-top:10px;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:545px;border-collapse:collapse;"><tr><td width="90px"></td><td width="53px"></td><td width="401px"></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2
px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">Attention:</font></div></td><td colspan="2" style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">Ms. Jennifer Riegel</font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;height:14px;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;height:14px;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;height:14px;fo
nt-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">Re:</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">Lexicon Pharmaceuticals, Inc.</font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div></td>
<td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">Request to Withdraw Registration Statement on Form S-3</font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padd
ing-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">Filed August 9, 2010</font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">File No. 333-168677</font></div></td></tr></table></div></div><div style="line-height:120%;text-align:left;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div><div style="line-hei
ght:120%;text-align:left;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">Dear Ms. Riegel:</font></div><div style="line-height:120%;text-align:left;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div><div style="line-height:120%;padding-bottom:16px;text-align:left;text-indent:48px;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">Pursuant to Rule 477 promulgated under the Securities Act of 1933, as amended, Lexicon Pharmaceuticals, Inc. (the &ldquo;</font><font style="font-family:inherit;font-size:11pt;text-decoration:underline;">Company</font><font style="font-family:inherit;font-size:11pt;">&rdquo;) hereby requests that the Securities and Exchange Commission (the &ldquo;</font><font style="font-family:inherit;font-size:11pt;text-decoration:underline;">Commission</font><font style="font-family:inherit;font-size:11pt;">&rdquo;) consent to the withdrawal, effective as of the date hereof or at the earliest practicable date hereafter, of its Registration Sta
tement on Form S-3 (File No. 333-168677), together with all exhibits and amendments thereto (collectively, the &ldquo;</font><font style="font-family:inherit;font-size:11pt;text-decoration:underline;">Registration Statement</font><font style="font-family:inherit;font-size:11pt;">&rdquo;).  The Registration Statement was originally filed with the Commission on August 9, 2010.</font></div><div style="line-height:120%;padding-bottom:16px;text-align:left;text-indent:48px;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">The Registration Statement is being withdrawn at the request of the Commission and relates to the offer and sale by a selling stockholder of shares of the Company's common stock that may be issued by the Company directly to the selling stockholder pursuant to an Amended and Restated Purchase Option Agreement with the selling stockholder.  The Company intends to re-file a registration statement on Form S-3 at the time such shares are issued to the selling stockholder.</font></div>
<div style="line-height:120%;padding-bottom:16px;text-align:left;text-indent:48px;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">Please do not hesitate to contact the undersigned at (281) 863-3321 with any comments or questions concerning this letter or the above-referenced registration statement.</font></div><div style="line-height:120%;padding-left:300px;text-align:justify;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">Very truly yours,</font></div><div style="line-height:120%;padding-left:300px;text-align:justify;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div><div style="line-height:120%;padding-left:300px;text-align:justify;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;">/s/ Jeffrey L. Wade</font></div><div style="line-height:120%;padding-left:300px;text-align:justify;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div><div style="line-height:120%;padding-left:300px;text-align:justify;font-size:11pt;"><f
ont style="font-family:inherit;font-size:11pt;">Jeffrey L. Wade</font></div><div style="line-height:120%;padding-left:300px;text-align:justify;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;font-style:italic;">Executive Vice President, Corporate Development and</font></div><div style="line-height:120%;padding-left:300px;text-align:justify;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;font-style:italic;">Chief Financial Officer</font></div><div style="line-height:120%;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div><br><div style="text-align:center;"><div style="line-height:120%;"><font style="font-family:inherit;font-size:10pt;">&nbsp;</font></div></div>	</body>
</html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
