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Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2011 | Dec. 31, 2010 | Dec. 31, 2009
Cash flows from operating activities: |  |  |
Consolidated net loss | $ (116,215) | $ (101,775) | $ (93,317)
Adjustments to reconcile consolidated net loss to net cash used in operating activities: |  |  |
Depreciation | 4,887 | 5,394 | 6,159
Impairment of fixed assets | 704 | 1,001 | 436
Amortization of Symphony Icon, Inc. purchase option | 0 | 3,957 | 2,141
Change in fair value of Symphony Icon, Inc. purchase liability | (6,766) | (2,710) | 0
Stock-based compensation | 5,707 | 5,478 | 5,274
Net gain on auction rate securities ("ARS") and ARS Rights | 0 | (141) | (1,173)
Changes in operating assets and liabilities: |  |  |
(Increase) decrease in receivables | 394 | 488 | (247)
(Increase) decrease in prepaid expenses and other current assets | (865) | 6,704 | (869)
(Increase) decrease in other assets | 414 | (218) | 104
Increase (decrease) in accounts payable and other liabilities | 10,365 | (5,238) | (2,794)
Decrease in deferred revenue | (95) | (728) | (4,730)
Net cash used in operating activities | (87,938) | (82,368) | (89,016)
Cash flows from investing activities: |  |  |
Purchases of property and equipment | (1,206) | (1,132) | (369)
Proceeds from disposal of property and equipment | 2,625 | 64 | 107
Purchases of investments held by Symphony Icon, Inc. | 0 | 0 | (4,250)
Maturities of investments held by Symphony Icon, Inc. | 0 | 0 | 15,443
Acquisition of Symphony Icon, Inc., net of cash acquired | 0 | (5,561) | 0
Purchases of investments | (108,092) | (155,856) | (59,955)
Maturities of investments | 176,628 | 48,641 | 60,901
Net cash provided by (used in) investing activities | 69,955 | (113,844) | 11,877
Cash flows from financing activities: |  |  |
Proceeds from issuance of common stock, net of fees | 160,781 | 181,496 | 55,436
Repurchase of common stock | (108) | (149) | (88)
Proceeds from debt borrowings | 0 | 11,377 | 38,592
Repayment of debt borrowings | (3,589) | (49,858) | (2,120)
Net cash provided by financing activities | 157,084 | 142,866 | 91,820
Net increase (decrease) in cash and cash equivalents | 139,101 | (53,346) | 14,681
Cash and cash equivalents at beginning of year | 47,208 | 100,554 | 85,873
Cash and cash equivalents at end of year | 186,309 | 47,208 | 100,554
Supplemental disclosure of cash flow information: |  |  |
Cash paid for interest | 2,447 | 2,424 | 2,519
Cash received related to income taxes | 0 | 26 | 102
Supplemental disclosure of noncash investing and financing activities: |  |  |
Unrealized gain on investments | 16 | 5 | 0
Intangible assets acquired with long-term liabilities | $ 0 | $ 43,557 | $ 0

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- Definition This item represents the change in fair value of the Symphony Icon, Inc. purchase liability. In connection with the acquisition of Symphony Icon, Lexicon made an initial estimate of the fair value of the liability for the associated based and contingent payments. Changes in this liability, based on the development of the programs and the time until such payments are expected to be made, are recorded in Lexicon's consolidated statements of operations. + References No definition available. + Details
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- Definition The cash outflow to reacquire common stock during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3291-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 18 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 20 -Subparagraph a -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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