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Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 12 Months Ended
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Cash flows from operating activities:      
Consolidated net loss $ (116,215) $ (101,775) $ (93,317)
Adjustments to reconcile consolidated net loss to net cash used in operating activities:      
Depreciation 4,887 5,394 6,159
Impairment of fixed assets 704 1,001 436
Amortization of Symphony Icon, Inc. purchase option 0 3,957 2,141
Change in fair value of Symphony Icon, Inc. purchase liability (6,766) (2,710) 0
Stock-based compensation 5,707 5,478 5,274
Net gain on auction rate securities ("ARS") and ARS Rights 0 (141) (1,173)
Changes in operating assets and liabilities:      
(Increase) decrease in receivables 394 488 (247)
(Increase) decrease in prepaid expenses and other current assets (865) 6,704 (869)
(Increase) decrease in other assets 414 (218) 104
Increase (decrease) in accounts payable and other liabilities 10,365 (5,238) (2,794)
Decrease in deferred revenue (95) (728) (4,730)
Net cash used in operating activities (87,938) (82,368) (89,016)
Cash flows from investing activities:      
Purchases of property and equipment (1,206) (1,132) (369)
Proceeds from disposal of property and equipment 2,625 64 107
Purchases of investments held by Symphony Icon, Inc. 0 0 (4,250)
Maturities of investments held by Symphony Icon, Inc. 0 0 15,443
Acquisition of Symphony Icon, Inc., net of cash acquired 0 (5,561) 0
Purchases of investments (108,092) (155,856) (59,955)
Maturities of investments 176,628 48,641 60,901
Net cash provided by (used in) investing activities 69,955 (113,844) 11,877
Cash flows from financing activities:      
Proceeds from issuance of common stock, net of fees 160,781 181,496 55,436
Repurchase of common stock (108) (149) (88)
Proceeds from debt borrowings 0 11,377 38,592
Repayment of debt borrowings (3,589) (49,858) (2,120)
Net cash provided by financing activities 157,084 142,866 91,820
Net increase (decrease) in cash and cash equivalents 139,101 (53,346) 14,681
Cash and cash equivalents at beginning of year 47,208 100,554 85,873
Cash and cash equivalents at end of year 186,309 47,208 100,554
Supplemental disclosure of cash flow information:      
Cash paid for interest 2,447 2,424 2,519
Cash received related to income taxes 0 26 102
Supplemental disclosure of noncash investing and financing activities:      
Unrealized gain on investments 16 5 0
Intangible assets acquired with long-term liabilities $ 0 $ 43,557 $ 0