<SEC-DOCUMENT>0001181431-12-023414.txt : 20120410
<SEC-HEADER>0001181431-12-023414.hdr.sgml : 20120410
<ACCEPTANCE-DATETIME>20120410173445
ACCESSION NUMBER:		0001181431-12-023414
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20120331
FILED AS OF DATE:		20120410
DATE AS OF CHANGE:		20120410

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Minne Pascal
		CENTRAL INDEX KEY:			0001460839

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		12752685

	MAIL ADDRESS:	
		STREET 1:		PLACE STE. GUDULE, 19
		CITY:			BRUXELLES
		STATE:			C9
		ZIP:			B-1000

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC./DE
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ARTAL GROUP S A
		CENTRAL INDEX KEY:			0001053906

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		12752683

	BUSINESS ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310
		BUSINESS PHONE:		3522242591

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ARTAL INTERNATIONAL SCA
		CENTRAL INDEX KEY:			0001218180

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		12752686

	BUSINESS ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310
		BUSINESS PHONE:		011003522242591

	MAIL ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310

	FORMER NAME:	
		FORMER CONFORMED NAME:	ARTAL INTERNATIONAL SA
		DATE OF NAME CHANGE:	20030210

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			WESTEND SA
		CENTRAL INDEX KEY:			0001283968
		STATE OF INCORPORATION:			N4
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		12752682

	BUSINESS ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBURG
		STATE:			N4
		ZIP:			L-2310
		BUSINESS PHONE:		3522242591

	MAIL ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBURG
		STATE:			N4
		ZIP:			L-2310

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Stichting Administratiekantoor Westend
		CENTRAL INDEX KEY:			0001460840

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		12752681

	BUSINESS ADDRESS:	
		STREET 1:		IJSSELBURCHT 3
		CITY:			ARNHEM
		STATE:			P7
		ZIP:			6825BS
		BUSINESS PHONE:		31 26 365 35 23

	MAIL ADDRESS:	
		STREET 1:		IJSSELBURCHT 3
		CITY:			ARNHEM
		STATE:			P7
		ZIP:			6825BS

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Artal International Management S.A.
		CENTRAL INDEX KEY:			0001522131
		STATE OF INCORPORATION:			N4
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		12752684

	BUSINESS ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310
		BUSINESS PHONE:		(352) 22.42.59-1

	MAIL ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>rrd341726.xml
<DESCRIPTION>FORM 3
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0205</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2012-03-31</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001062822</issuerCik>
        <issuerName>LEXICON PHARMACEUTICALS, INC./DE</issuerName>
        <issuerTradingSymbol>LXRX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001218180</rptOwnerCik>
            <rptOwnerName>ARTAL INTERNATIONAL SCA</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10-12 AVENUE PASTEUR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2310</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001522131</rptOwnerCik>
            <rptOwnerName>Artal International Management S.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10-12 AVENUE PASTEUR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2310</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001053906</rptOwnerCik>
            <rptOwnerName>ARTAL GROUP S A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10-12 AVENUE PASTEUR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2310</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001283968</rptOwnerCik>
            <rptOwnerName>WESTEND SA</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10-12 AVENUE PASTEUR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2310</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001460840</rptOwnerCik>
            <rptOwnerName>Stichting Administratiekantoor Westend</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>DE BOELELAAN 7,</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>AMSTERDAM</rptOwnerCity>
            <rptOwnerState>P7</rptOwnerState>
            <rptOwnerZipCode>NL-1083 HJ</rptOwnerZipCode>
            <rptOwnerStateDescription>NETHERLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001460839</rptOwnerCik>
            <rptOwnerName>Minne Pascal</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>PLACE STE. GUDULE, 19</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BRUXELLES</rptOwnerCity>
            <rptOwnerState>C9</rptOwnerState>
            <rptOwnerZipCode>B-1000</rptOwnerZipCode>
            <rptOwnerStateDescription>BELGIUM</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>250372135</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">244,818,843 of the reported shares of Issuer common stock are owned directly by Invus, L.P. and 5,553,292 of the reported shares of Issuer common stock are owned directly by Invus Public Equities, L.P. Invus Advisors, L.L.C. is the general partner of Invus, L.P., and Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P. Artal International S.C.A. is the managing member of each of Invus Advisors, L.L.C. and Invus Public Equities Advisors, LLC. Artal International Management S.A. is the general partner of Artal International S.C.A., which is a wholly owned subsidiary of Artal Group S.A., which is a wholly owned subsidiary of Westend S.A., which is a wholly owned subsidiary of Stichting Administratiekantoor Westend (the &quot;Stichting&quot;). (Continued in Footnote 2)</footnote>
        <footnote id="F2">Mr. Pascal Minne is the sole member of the board of the Stichting. Accordingly, each of Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., the Stichting and Mr. Minne may be deemed to be indirect beneficial owners of the reported securities. Each of Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., the Stichting and Mr. Minne disclaims beneficial ownership of such securities, except to the extent of its or his pecuniary interest therein.</footnote>
    </footnotes>

    <remarks>For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., the Stichting and Mr. Minne may be deemed to be directors by deputization of the Issuer by virtue of Invus, L.P.'s right to designate certain members of the Issuer's board of directors pursuant to a stockholders' agreement between the Issuer and Invus, L.P.</remarks>

    <ownerSignature>
        <signatureName>/s/ Anne Goffard, Managing Director for ARTAL INTERNATIONAL MANAGEMENT S.A., managing partner for ARTAL INTERNATIONAL S.C.A.</signatureName>
        <signatureDate>2012-04-10</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Anne Goffard, Managing Director for ARTAL INTERNATIONAL MANAGEMENT S.A.</signatureName>
        <signatureDate>2012-04-10</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Anne Goffard, Authorized Person for ARTAL GROUP S.A.</signatureName>
        <signatureDate>2012-04-10</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Pascal Minne, Director for WESTEND S.A.</signatureName>
        <signatureDate>2012-04-10</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Pascal Minne, Sole Member of the Board for STICHTING ADMINISTRATIEKANTOOR WESTEND</signatureName>
        <signatureDate>2012-04-10</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Pascal Minne</signatureName>
        <signatureDate>2012-04-10</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
