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Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
Cash flows from operating activities: |  |  |
Consolidated net loss | $ (110,211) | $ (116,215) | $ (101,775)
Adjustments to reconcile consolidated net loss to net cash used in operating activities: |  |  |
Depreciation | 4,190 | 4,887 | 5,394
Impairment of fixed assets | 0 | 704 | 1,001
Amortization of Symphony Icon, Inc. purchase option | 0 | 0 | 3,957
Increase in fair value of Symphony Icon, Inc. purchase liability | 9,887 | 6,766 | 2,710
Stock-based compensation | 6,495 | 5,707 | 5,478
Net gain on auction rate securities ("ARS") and ARS Rights | 0 | 0 | (141)
Changes in operating assets and liabilities: |  |  |
(Increase) decrease in accounts receivable | (1,028) | 394 | 488
(Increase) decrease in prepaid expenses and other current assets | (2,601) | (865) | 6,704
(Increase) decrease in other assets | 96 | 414 | (218)
Increase (decrease) in accounts payable and other liabilities | (995) | 10,365 | (5,238)
Decrease in deferred revenue | (293) | (95) | (728)
Net cash used in operating activities | (94,460) | (87,938) | (82,368)
Cash flows from investing activities: |  |  |
Purchases of property and equipment | (492) | (1,206) | (1,132)
Proceeds from disposal of property and equipment | 85 | 2,625 | 64
Acquisition of Symphony Icon, Inc., net of cash acquired | 0 | 0 | (5,561)
Purchases of investments | (233,250) | (108,092) | (155,856)
Maturities of investments | 135,850 | 176,628 | 48,641
Net cash provided by (used in) investing activities | (97,807) | 69,955 | (113,844)
Cash flows from financing activities: |  |  |
Proceeds from issuance of common stock, net of fees | 38,109 | 160,781 | 181,496
Repurchase of common stock | (285) | (108) | (149)
Proceeds from debt borrowings | 0 | 0 | 11,377
Repayment of debt borrowings | (1,443) | (3,589) | (49,858)
Net cash provided by financing activities | 36,381 | 157,084 | 142,866
Net increase (decrease) in cash and cash equivalents | (155,886) | 139,101 | (53,346)
Cash and cash equivalents at beginning of year | 186,309 | 47,208 | 100,554
Cash and cash equivalents at end of year | 30,423 | 186,309 | 47,208
Supplemental disclosure of cash flow information: |  |  |
Cash paid for interest | 2,028 | 2,447 | 2,424
Cash received related to income taxes | 0 | 0 | 26
Supplemental disclosure of noncash investing and financing activities: |  |  |
Unrealized gain on investments | 2 | 16 | 5
Common stock issued in satisfaction of Symphony Icon base payment obligation | 35,000 | 0 | 0
Intangible assets acquired with long-term liabilities | $ 0 | $ 0 | $ 43,557

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- Definition This item represents the change in fair value of the Symphony Icon, Inc. purchase liability. In connection with the acquisition of Symphony Icon, Lexicon made an initial estimate of the fair value of the liability for the associated based and contingent payments. Changes in this liability, based on the development of the programs and the time until such payments are expected to be made, are recorded in Lexicon's consolidated statements of operations. + References No definition available. + Details
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- Definition On July 30, 2010, Lexicon entered into an Amended and Restated Purchase Option Agreement with Symphony Icon and Holdings and simultaneously exercised the Purchase Option, thereby reacquiring the Programs. Pursuant to the amended terms of the Purchase Option, Lexicon paid Holdings $10 million and issued 13,237,591 shares of common stock to designees of Holdings on July 30, 2012 in satisfaction of an additional $35 million base payment obligation. Lexicon also agreed to make up to $45 million in additional payments, which will consist of 50% of any consideration Lexicon receives pursuant to any licensing transaction under which Lexicon grants a third party rights to commercialize LX1032, LX1033 or other pharmaceutical compositions modulating the same target as those drug candidates. This represents the shares issued to designees of Holdings during the period. + References No definition available. + Details
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- Definition The cash outflow to reacquire common stock during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 20 -Subparagraph a -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 18 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3291-108585 + Details
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