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Fair Value Measurements | 12 Months Ended
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Dec. 31, 2012
Fair Value Measurements [Abstract] |
Fair Value Measurements | Fair Value Measurements The Company uses various inputs in determining the fair value of its investments and measures these assets on a recurring basis. Assets and liabilities recorded at fair value in the consolidated balance sheets are categorized by the level of objectivity associated with the inputs used to measure their fair value. The following levels are directly related to the amount of subjectivity associated with the inputs to fair valuation of these assets and liabilities:
• | Level 1 – quoted prices in active markets for identical assets
• | Level 2 – other significant observable inputs (including quoted prices for similar investments, market corroborated inputs, etc.)
• | Level 3 – significant unobservable inputs (including the Company’s own assumptions in determining the fair value of assets and liabilities)
The inputs or methodology used for valuing securities are not necessarily an indication of the credit risk associated with investing in those securities. The following tables provide the fair value measurements of applicable Company assets and liabilities that are measured at fair value on a recurring basis according to the fair value levels defined above as of December 31, 2012 and 2011.
| Assets and Liabilities at Fair Value
| As of December 31, 2012
| Level 1 |  | Level 2 |  | Level 3 |  | Total
| (in thousands)
Assets |  |  |  |  |  |  |
Cash and cash equivalents | $ | 30,423 |  |  | $ | — |  |  | $ | — |  |  | $ | 30,423 |
Short-term investments | 192,785 |  |  | — |  |  | — |  |  | 192,785 |
Total cash and cash equivalents and investments | $ | 223,208 |  |  | $ | — |  |  | $ | — |  |  | $ | 223,208 |
Liabilities |  |  |  |  |  |  |
Other long-term liabilities | $ | — |  |  | $ | — |  |  | $ | 29,920 |  |  | $ | 29,920 |
Total liabilities | $ | — |  |  | $ | — |  |  | $ | 29,920 |  |  | $ | 29,920 |
| Assets and Liabilities at Fair Value
| As of December 31, 2011
| Level 1 |  | Level 2 |  | Level 3 |  | Total
| (in thousands)
Assets |  |  |  |  |  |  |
Cash and cash equivalents | $ | 186,309 |  |  | $ | — |  |  | $ | — |  |  | $ | 186,309 |
Short-term investments | 95,383 |  |  | — |  |  | — |  |  | 95,383 |
Total cash and cash equivalents and investments | $ | 281,692 |  |  | $ | — |  |  | $ | — |  |  | $ | 281,692 |
Liabilities |  |  |  |  |  |  |
Other long-term liabilities | $ | — |  |  | $ | — |  |  | $ | 55,033 |  |  | $ | 55,033 |
Total liabilities | $ | — |  |  | $ | — |  |  | $ | 55,033 |  |  | $ | 55,033 |
The Company did not have any Level 3 financial assets during the years ended December 31, 2012 and 2011. In 2010, Lexicon held auction rate securities and related rights that permitted Lexicon to require the investment bank that sold Lexicon the auction rate securities to purchase its auction rate securities at par value. On June 30, 2010, Lexicon exercised the rights and the investment bank purchased Lexicon's remaining auction rate securities at par value on July 1, 2010. The table presented below summarizes the change in consolidated balance sheet carrying value associated with Level 3 financial assets for the year ended December 31, 2010.
| Short-term Investments
| (in thousands)
Balance at December 31, 2009 | $ | 56,034 |
Unrealized gains included in earnings as gain on investments, net | 141 |
Net sales and settlements | (56,175 | )
Balance at December 31, 2010 | $ | — |
Transfers between levels are recognized at the actual date of circumstance that caused the transfer. The Company's Level 3 liabilities are estimated using a probability-based income approach utilizing an appropriate discount rate. Subsequent changes in the fair value of the Symphony Icon purchase consideration liability are recorded as an increase or decrease in Symphony Icon purchase liability in the accompanying consolidated statements of comprehensive loss. During the years ended December 31, 2012, 2011 and 2010, the fair value of the Symphony Icon ("Symphony Icon") purchase consideration liability increased by $9.9 million, $6.8 million and $2.7 million, respectively. The following table summarizes the change in consolidated balance sheet carrying value associated with Level 3 liabilities for the years ended December 31, 2010, 2011 and 2012.
| Other Long-term Liabilities
| (in thousands)
Balance at December 31, 2009 | $ | — |
Purchase consideration liability resulting from the Symphony Icon acquisition | 45,557 |
Change in valuation of purchase consideration payable to former Symphony Icon stockholders | 2,710 |
Balance at December 31, 2010 | 48,267 |
Change in valuation of purchase consideration payable to former Symphony Icon stockholders | 6,766 |
Balance at December 31, 2011 | 55,033 |
Change in valuation of purchase consideration payable to former Symphony Icon stockholders | 9,887 |
Payment of base payment obligation with common stock | (35,000 | )
Balance at December 31, 2012 | $ | 29,920 |
The Company also has assets that under certain conditions are subject to measurement at fair value on a non-recurring basis. These assets include goodwill associated with the acquisitions of Coelacanth Corporation in 2001 and Symphony Icon on July 30, 2010 and intangible assets associated with the acquisition of Symphony Icon on July 30, 2010. For these assets, measurement at fair value in periods subsequent to their initial recognition is applicable if one or more is determined to be impaired.

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- Definition The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 16 -URI http://asc.fasb.org/extlink&oid=7491637&loc=d3e13504-108611 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 107 -Paragraph 15C, 15D -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 133 -Paragraph 44A, 44B -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 107 -Paragraph 15A -Subparagraph a-d -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 107 -Paragraph 3, 10, 14, 15 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 10 -URI http://asc.fasb.org/extlink&oid=7491637&loc=d3e13433-108611 Reference 7: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 159 -Paragraph 17-22, 27, 28 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. 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