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Consolidated Statements of Comprehensive Loss (USD $) In Thousands, except Per Share data, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
Revenues: |  |  |
Collaborative research | $ 783 | $ 1,632 | $ 4,191
Subscription and license fees | 306 | 217 | 717
Total revenues | 1,089 | 1,849 | 4,908
Operating expenses: |  |  |
Research and development, including stock-based compensation of $3,673, $3,249 and $3,170, respectively | 82,574 | 91,828 | 78,520
Increase in fair value of Symphony Icon, Inc. purchase liability | 9,887 | 6,766 | 2,710
General and administrative, including stock-based compensation of $2,822, $2,458 and $2,308, respectively | 17,043 | 17,350 | 19,396
Total operating expenses | 109,504 | 115,944 | 100,626
Loss from operations | (108,415) | (114,095) | (95,718)
Gain on investments, net | 0 | 0 | 141
Interest income | 213 | 255 | 519
Interest expense | (2,114) | (2,528) | (2,719)
Other income (expense), net | 105 | 153 | (4,024)
Consolidated net loss before taxes | (110,211) | (116,215) | (101,801)
Income tax benefit | 0 | 0 | 26
Consolidated net loss | (110,211) | (116,215) | (101,775)
Consolidated net loss per common share, basic and diluted | $ (0.23) | $ (0.34) | $ (0.34)
Shares used in computing consolidated net loss per common share, basic and diluted | 489,707 | 340,761 | 302,844
Other comprehensive gain (loss): |  |  |
Unrealized gain on investments | 2 | 16 | 5
Comprehensive loss | $ (110,209) | $ (116,199) | $ (101,770)

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- Definition This item represents the change in fair value of the Symphony Icon, Inc. purchase liability. In connection with the acquisition of Symphony Icon, Lexicon made an initial estimate of the fair value of the liability for the associated based and contingent payments. Changes in this liability, based on the development of the programs and the time until such payments are expected to be made, are recorded in Lexicon's consolidated statements of operations. + References No definition available. + Details
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Name: | us-gaap_RevenuesAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS). + References No definition available. + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | duration