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Consolidated Statements of Comprehensive Loss (Unaudited) (USD $)
In Thousands, except Per Share data, unless otherwise specified
 3 Months Ended 6 Months Ended
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2013
Jun. 30, 2012
Revenues:        
Collaborative research $ 211 $ 199 $ 495 $ 351
Subscription and license fees 3 0 79 148
Total revenues 214 199 574 499
Operating expenses:        
Research and development, including stock-based compensation of $1,022, $915, $2,352 and $1,952, respectively 23,692 19,355 44,019 42,392
Increase in fair value of Symphony Icon, Inc. purchase liability 477 2,162 1,741 4,243
General and administrative, including stock-based compensation of $847, $680, $1,626 and $1,361, respectively 4,669 4,162 8,993 8,727
Total operating expenses 28,838 25,679 54,753 55,362
Loss from operations (28,624) (25,480) (54,179) (54,863)
Interest income 44 58 97 114
Interest expense (496) (530) (1,002) (1,067)
Other income (expense), net (4) 21 30 17
Consolidated net loss (29,080) (25,931) (55,054) (55,799)
Consolidated net loss per common share, basic and diluted $ (0.06) $ (0.05) $ (0.11) $ (0.12)
Weighted Average Number of Shares Outstanding, Basic and Diluted 513,083 480,634 512,757 480,479
Unrealized gain (loss) on investments (11) 37 8 (41)
Comprehensive loss $ (29,091) $ (25,894) $ (55,046) $ (55,840)