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Consolidated Statements of Comprehensive Loss (USD $)
In Thousands, except Per Share data, unless otherwise specified
 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Revenues:      
Collaborative research $ 2,109 $ 783 $ 1,632
Subscription and license fees 113 306 217
Total revenues 2,222 1,089 1,849
Operating expenses:      
Research and development, including stock-based compensation of $4,376, $3,673 and $3,249, respectively 89,682 82,574 91,828
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability (2,210) 9,887 6,766
General and administrative, including stock-based compensation of $3,045, $2,822 and $2,458, respectively 17,121 17,043 17,350
Total operating expenses 104,593 109,504 115,944
Loss from operations (102,371) (108,415) (114,095)
Interest income 157 213 255
Interest expense (1,971) (2,114) (2,528)
Other income, net 59 105 153
Consolidated net loss (104,126) (110,211) (116,215)
Consolidated net loss per common share, basic and diluted $ (0.20) $ (0.23) $ (0.34)
Shares used in computing consolidated net loss per common share, basic and diluted 513,117 489,707 340,761
Other comprehensive gain (loss):      
Unrealized gain (loss) on investments (21) 2 16
Comprehensive loss $ (104,147) $ (110,209) $ (116,199)