<SEC-DOCUMENT>0001209191-14-071632.txt : 20141126
<SEC-HEADER>0001209191-14-071632.hdr.sgml : 20141126
<ACCEPTANCE-DATETIME>20141126191947
ACCESSION NUMBER:		0001209191-14-071632
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20141126
FILED AS OF DATE:		20141126
DATE AS OF CHANGE:		20141126

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC./DE
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus Public Equities Advisors, LLC
		CENTRAL INDEX KEY:			0001340096

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		141254764

	BUSINESS ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		(212) 371-1717

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus Advisors, L.L.C.
		CENTRAL INDEX KEY:			0001404553

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		141254765

	BUSINESS ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		(212) 371-1717

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Artal International Management S.A.
		CENTRAL INDEX KEY:			0001522131
		STATE OF INCORPORATION:			N4
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		141254769

	BUSINESS ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310
		BUSINESS PHONE:		352224259-1

	MAIL ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus, L.P.
		CENTRAL INDEX KEY:			0001404570

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		141254771

	BUSINESS ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		(212) 371-1717

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Minne Pascal
		CENTRAL INDEX KEY:			0001460839

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		141254772

	MAIL ADDRESS:	
		STREET 1:		PLACE STE. GUDULE, 19
		CITY:			BRUXELLES
		STATE:			C9
		ZIP:			B-1000

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus Public Equities, L.P.
		CENTRAL INDEX KEY:			0001340097

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		141254770

	BUSINESS ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212-317-7520

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

	FORMER NAME:	
		FORMER CONFORMED NAME:	Invus Public Equities, LP
		DATE OF NAME CHANGE:	20050928

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Stichting Administratiekantoor Westend
		CENTRAL INDEX KEY:			0001460840
		STATE OF INCORPORATION:			XX

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		141254766

	BUSINESS ADDRESS:	
		STREET 1:		DE BOELELAAN 7
		CITY:			AMSTERDAM
		STATE:			P7
		ZIP:			NL-1083 HJ
		BUSINESS PHONE:		352-224-2591

	MAIL ADDRESS:	
		STREET 1:		DE BOELELAAN 7
		CITY:			AMSTERDAM
		STATE:			P7
		ZIP:			NL-1083 HJ

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Artal International S.C.A.
		CENTRAL INDEX KEY:			0001218180

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		141254773

	BUSINESS ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310
		BUSINESS PHONE:		352224259-1

	MAIL ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310

	FORMER NAME:	
		FORMER CONFORMED NAME:	ARTAL INTERNATIONAL SCA
		DATE OF NAME CHANGE:	20110531

	FORMER NAME:	
		FORMER CONFORMED NAME:	ARTAL INTERNATIONAL SA
		DATE OF NAME CHANGE:	20030210

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Westend S.A.
		CENTRAL INDEX KEY:			0001283968
		STATE OF INCORPORATION:			N4
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		141254767

	BUSINESS ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310
		BUSINESS PHONE:		3522242591

	MAIL ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310

	FORMER NAME:	
		FORMER CONFORMED NAME:	WESTEND S.A.
		DATE OF NAME CHANGE:	20120816

	FORMER NAME:	
		FORMER CONFORMED NAME:	WESTEND SA
		DATE OF NAME CHANGE:	20040317

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Artal Group S.A.
		CENTRAL INDEX KEY:			0001053906

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		141254768

	BUSINESS ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310
		BUSINESS PHONE:		(352) 22.42.59-1

	MAIL ADDRESS:	
		STREET 1:		10-12 AVENUE PASTEUR
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2310

	FORMER NAME:	
		FORMER CONFORMED NAME:	ARTAL GROUP S A
		DATE OF NAME CHANGE:	19980128
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2014-11-26</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001062822</issuerCik>
        <issuerName>LEXICON PHARMACEUTICALS, INC./DE</issuerName>
        <issuerTradingSymbol>LXRX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001218180</rptOwnerCik>
            <rptOwnerName>Artal International S.C.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10-12 AVENUE PASTEUR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2310</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001460839</rptOwnerCik>
            <rptOwnerName>Minne Pascal</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>PLACE STE. GUDULE, 19</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BRUXELLES</rptOwnerCity>
            <rptOwnerState>C9</rptOwnerState>
            <rptOwnerZipCode>B-1000</rptOwnerZipCode>
            <rptOwnerStateDescription>BELGIUM</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001404570</rptOwnerCik>
            <rptOwnerName>Invus, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>CLARENDON HOUSE, 2 CHURCH STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>HAMILTON HM II</rptOwnerCity>
            <rptOwnerState>D0</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>BERMUDA</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001340097</rptOwnerCik>
            <rptOwnerName>Invus Public Equities, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>CLARENDON HOUSE, 2 CHURCH STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>HAMILTON HM II</rptOwnerCity>
            <rptOwnerState>D0</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>BERMUDA</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001522131</rptOwnerCik>
            <rptOwnerName>Artal International Management S.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10-12 AVENUE PASTEUR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2310</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001053906</rptOwnerCik>
            <rptOwnerName>Artal Group S.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10-12 AVENUE PASTEUR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2310</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001283968</rptOwnerCik>
            <rptOwnerName>Westend S.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10-12 AVENUE PASTEUR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2310</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001460840</rptOwnerCik>
            <rptOwnerName>Stichting Administratiekantoor Westend</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>DE BOELELAAN 7,</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>AMSTERDAM</rptOwnerCity>
            <rptOwnerState>P7</rptOwnerState>
            <rptOwnerZipCode>NL-1083 HJ</rptOwnerZipCode>
            <rptOwnerStateDescription>NETHERLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001404553</rptOwnerCik>
            <rptOwnerName>Invus Advisors, L.L.C.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>750 LEXINGTON AVENUE, 30TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001340096</rptOwnerCik>
            <rptOwnerName>Invus Public Equities Advisors, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>750 LEXINGTON AVENUE, 30TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2014-11-26</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>149253731</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1.005</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>149253731</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>247818843</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5553292</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">These securities are directly held by Artal International S.C.A.</footnote>
        <footnote id="F2">These securities are directly held by Invus, L.P.</footnote>
        <footnote id="F3">These securities are directly held by Invus Public Equities, L.P.</footnote>
        <footnote id="F4">Invus Advisors, L.L.C. is the general partner of Invus, L.P., and Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P. Artal International S.C.A. is the managing member of each of Invus Advisors, L.L.C. and Invus Public Equities Advisors, LLC. The managing partner of Artal International S.C.A. is Artal International Management S.A., both of which are wholly owned subsidiaries of Artal Group S.A., which is a wholly owned subsidiary of Westend S.A., which is a wholly owned subsidiary of Stichting Administratiekantoor Westend (the &quot;Stichting&quot;). Mr. Pascal Minne is the sole member of the board of the Stichting.</footnote>
        <footnote id="F5">Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the &quot;Exchange Act&quot;), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 or for any other purpose.</footnote>
    </footnotes>

    <remarks>Invus C.V. directly holds 29,782,609 shares of Issuer common stock. None of the Reporting Persons listed in Footnote 4 hereof have any beneficial or pecuniary interest for purposes of Section 16 of the Exchange Act in the shares of Issuer common stock directly held by Invus C.V.

For purposes of Section 16 of the Exchange Act, the Reporting Persons may be deemed to be directors by deputization of the Issuer by virtue of Invus, L.P.'s right to designate certain members of the Issuer's board of directors pursuant to a stockholders' agreement between the Issuer and Invus, L.P.</remarks>

    <ownerSignature>
        <signatureName>ARTAL INTERNATIONAL S.C.A., By: ARTAL INTERNATIONAL MANAGEMENT S.A., its managing partner, By: /s/ Anne Goffard, Name: Anne Goffard, Title: Managing Director</signatureName>
        <signatureDate>2014-11-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>INVUS, L.P., By: INVUS ADVISORS, L.L.C., its general partner, By: /s/ Raymond Debbane, Name: Raymond Debbane, Title: President</signatureName>
        <signatureDate>2014-11-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>INVUS PUBLIC EQUITIES, L.P., By: INVUS PUBLIC EQUITIES ADVISORS, LLC., its general partner, By: /s/ Raymond Debbane, Name: Raymond Debbane, Title: President</signatureName>
        <signatureDate>2014-11-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>INVUS ADVISORS, L.L.C., By: /s/ Raymond Debbane, Name: Raymond Debbane, Title: President</signatureName>
        <signatureDate>2014-11-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>INVUS PUBLIC EQUITIES ADVISORS, LLC, By: /s/ Raymond Debbane, Name: Raymond Debbane, Title: President</signatureName>
        <signatureDate>2014-11-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>ARTAL INTERNATIONAL MANAGEMENT S.A., By: /s/ Anne Goffard, Name: Anne Goffard, Title: Managing Director</signatureName>
        <signatureDate>2014-11-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>ARTAL GROUP S.A., By: /s/ Anne Goffard, Name: Anne Goffard, Title: Authorized Person</signatureName>
        <signatureDate>2014-11-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>WESTEND S.A., By: /s/ Pascal Minne, Name: Pascal Minne, Title: Director</signatureName>
        <signatureDate>2014-11-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>STICHTING ADMINISTRATIEKANTOOR WESTEND, By: /s/ Pascal Minne, Name: Pascal Minne, Title: Sole Member of the Board</signatureName>
        <signatureDate>2014-11-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>PASCAL MINNE, /s/ Pascal Minne</signatureName>
        <signatureDate>2014-11-26</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
