<SEC-DOCUMENT>0001193125-14-422675-index.html : 20141124
<SEC-HEADER>0001193125-14-422675.hdr.sgml : 20141124
<ACCEPTANCE-DATETIME>20141124091837
ACCESSION NUMBER:		0001193125-14-422675
CONFORMED SUBMISSION TYPE:	424B2
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20141124
DATE AS OF CHANGE:		20141124

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC./DE
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B2
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-198493
		FILM NUMBER:		141245159

	BUSINESS ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B2
<SEQUENCE>1
<FILENAME>d821183d424b2.htm
<DESCRIPTION>424B2
<TEXT>
Document 1 - file: d821183d424b2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g821183g05j45.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: g821183g05j45.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g821183g65v76.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: g821183g65v76.jpg

</DOCUMENT>
</SEC-DOCUMENT>