<SEC-DOCUMENT>0001062822-14-000034-index.html : 20140829
<SEC-HEADER>0001062822-14-000034.hdr.sgml : 20140829
<ACCEPTANCE-DATETIME>20140829161616
ACCESSION NUMBER:		0001062822-14-000034
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20140829
DATE AS OF CHANGE:		20140829

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC./DE
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-198493
		FILM NUMBER:		141075505

	BUSINESS ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3
<SEQUENCE>1
<FILENAME>august2014universalshelfon.htm
<DESCRIPTION>S-3
<TEXT>
Document 1 - file: august2014universalshelfon.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.10
<SEQUENCE>2
<FILENAME>exhibit410-formofindenture.htm
<DESCRIPTION>FORM OF INDENTURE
<TEXT>
Document 2 - file: exhibit410-formofindenture.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>exh51opinionofvinsonelkins.htm
<DESCRIPTION>OPINION OF VINSON & ELKINS LLP
<TEXT>
Document 3 - file: exh51opinionofvinsonelkins.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-12.1
<SEQUENCE>4
<FILENAME>exhibit121statementofcompu.htm
<DESCRIPTION>RATIO OF EARNINGS TO FIXED CHARGES
<TEXT>
Document 4 - file: exhibit121statementofcompu.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>5
<FILENAME>exh231consentofindependent.htm
<DESCRIPTION>CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
<TEXT>
Document 5 - file: exh231consentofindependent.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>logo.jpg
<TEXT>
Document 6 - file: logo.jpg

</DOCUMENT>
</SEC-DOCUMENT>