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Cash and Cash Equivalents and Investments (Details 1) - USD ($)
$ in Thousands
Mar. 31, 2016
Dec. 31, 2015
Cash and Cash Equivalents    
Fair Value    
Amortized Cost $ 24,681 $ 202,989
Gross Unrealized Gains 0 0
Gross Unrealized Losses 0 0
Estimated Fair Value 24,681 202,989
U.S. Treasury Securities    
Fair Value    
Amortized Cost 434,505 313,105
Gross Unrealized Gains 305 2
Gross Unrealized Losses (7) (219)
Estimated Fair Value 434,803 312,888
Corporate Debt Securities    
Fair Value    
Amortized Cost 17,663 5,477
Gross Unrealized Gains 2 0
Gross Unrealized Losses (3) (2)
Estimated Fair Value 17,662 5,475
Total Short-term Investments    
Fair Value    
Amortized Cost 452,168 318,582
Gross Unrealized Gains 307 2
Gross Unrealized Losses (10) (221)
Estimated Fair Value 452,465 318,363
Total Cash and Cash Equivalents and Investments    
Fair Value    
Amortized Cost 476,849 521,571
Gross Unrealized Gains 307 2
Gross Unrealized Losses (10) (221)
Estimated Fair Value $ 477,146 $ 521,352