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Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Revenues:
Collaborative agreements	$ 20,001	$ 338	$ 32,495	$ 2,130
Subscription and license fees	88	38	88	38
Total revenues	20,089	376	32,583	2,168
Operating expenses:
Research and development, including stock-based compensation of $973, $868, $1,962 and $1,972, respectively	48,216	20,769	85,218	41,634
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability	478	(12)	1,443	1,741
General and administrative, including stock-based compensation of $984, $920, $1,830 and $1,769, respectively	8,416	6,307	16,814	12,008
Total operating expenses	57,110	27,064	103,475	55,383
Loss from operations	(37,021)	(26,688)	(70,892)	(53,215)
Interest expense	(1,638)	(1,655)	(3,287)	(3,357)
Interest and other income, net	547	269	1,184	422
Net loss	$ (38,112)	$ (28,074)	$ (72,995)	$ (56,150)
Net loss per common share, basic and diluted	$ (0.37)	$ (0.27)	$ (0.70)	$ (0.54)
Shares used in computing consolidated net loss per common share, basic and diluted	103,830	103,608	103,756	103,562
Unrealized gain on investments	$ 39	$ 75	$ 555	$ 161
Comprehensive loss	$ (38,073)	$ (27,999)	$ (72,440)	$ (55,989)

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- Definition

This item represents the change in fair value of the Symphony Icon, Inc. purchase liability. In connection with the acquisition of Symphony Icon, Lexicon made an initial estimate of the fair value of the liability for the associated based and contingent payments. Changes in this liability, based on the development of the programs and the time until such payments are expected to be made, are recorded in Lexicon's consolidated statements of operations.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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