    <SEC-DOCUMENT>0001062822-16-000042-index.html : 20160122
    <SEC-HEADER>0001062822-16-000042.hdr.sgml : 20160122
    <ACCEPTANCE-DATETIME>20160122161146
    ACCESSION NUMBER:		0001062822-16-000042
    CONFORMED SUBMISSION TYPE:	8-K
    PUBLIC DOCUMENT COUNT:		20
    CONFORMED PERIOD OF REPORT:	20160121
    ITEM INFORMATION:		Entry into a Material Definitive Agreement
    ITEM INFORMATION:		Financial Statements and Exhibits
    FILED AS OF DATE:		20160122
    DATE AS OF CHANGE:		20160122

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC.
    		CENTRAL INDEX KEY:			0001062822
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				760474169
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		8-K
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	000-30111
    		FILM NUMBER:		161356349

    	BUSINESS ADDRESS:
    		STREET 1:		8800 TECHNOLOGY FOREST PLACE
    		CITY:			THE WOODLANDS
    		STATE:			TX
    		ZIP:			77381
    		BUSINESS PHONE:		2818633000

    	MAIL ADDRESS:
    		STREET 1:		8800 TECHNOLOGY FOREST PLACE
    		CITY:			THE WOODLANDS
    		STATE:			TX
    		ZIP:			77381

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	LEXICON PHARMACEUTICALS, INC./DE
    		DATE OF NAME CHANGE:	20070426

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
    		DATE OF NAME CHANGE:	20000126
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>8-K
    <SEQUENCE>1
    <FILENAME>form8-k01x22x2016.htm
    <DESCRIPTION>8-K
    <TEXT>
    Document 1 - file: form8-k01x22x2016.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.1
    <SEQUENCE>2
    <FILENAME>exh101realestatepurchasean.htm
    <DESCRIPTION>EXHIBIT 10.1
    <TEXT>
    Document 2 - file: exh101realestatepurchasean.htm

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>g1a02.jpg
    <TEXT>
    Document 3 - file: g1a02.jpg

    </DOCUMENT>
    <DOCUMENT>
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    <SEQUENCE>4
    <FILENAME>g2.jpg
    <TEXT>
    Document 4 - file: g2.jpg

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    <SEQUENCE>5
    <FILENAME>g3.jpg
    <TEXT>
    Document 5 - file: g3.jpg

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    <SEQUENCE>6
    <FILENAME>g4.jpg
    <TEXT>
    Document 6 - file: g4.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>g5.jpg
    <TEXT>
    Document 7 - file: g5.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>g6.jpg
    <TEXT>
    Document 8 - file: g6.jpg

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    <DOCUMENT>
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    <SEQUENCE>9
    <FILENAME>g7.jpg
    <TEXT>
    Document 9 - file: g7.jpg

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    <SEQUENCE>10
    <FILENAME>g8.jpg
    <TEXT>
    Document 10 - file: g8.jpg

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    <SEQUENCE>11
    <FILENAME>g9.jpg
    <TEXT>
    Document 11 - file: g9.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>g10.jpg
    <TEXT>
    Document 12 - file: g10.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>g11.jpg
    <TEXT>
    Document 13 - file: g11.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>g12.jpg
    <TEXT>
    Document 14 - file: g12.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>15
    <FILENAME>g13.jpg
    <TEXT>
    Document 15 - file: g13.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>16
    <FILENAME>g14.jpg
    <TEXT>
    Document 16 - file: g14.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>17
    <FILENAME>g15.jpg
    <TEXT>
    Document 17 - file: g15.jpg

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    <SEQUENCE>18
    <FILENAME>g16.jpg
    <TEXT>
    Document 18 - file: g16.jpg

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    <SEQUENCE>19
    <FILENAME>g17.jpg
    <TEXT>
    Document 19 - file: g17.jpg

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    <SEQUENCE>20
    <FILENAME>g18.jpg
    <TEXT>
    Document 20 - file: g18.jpg

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    </SEC-DOCUMENT>