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Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2017 | Mar. 31, 2016
Revenues: |  |
Net product revenue | $ 721 | $ 0
Collaborative agreements | 17,565 | 12,494
Subscription and license fees | 7 | 0
Total revenues | 18,293 | 12,494
Operating expenses: |  |
Cost of sales (including finite-lived intangible asset amortization) | 225 | 0
Research and development, including stock-based compensation of $1,184 and $989, respectively | 43,581 | 37,002
Increase in fair value of Symphony Icon, Inc. purchase liability | 2,101 | 965
Selling, general and administrative, including stock-based compensation of $1,047 and $846, respectively | 14,871 | 8,398
Total operating expenses | 60,778 | 46,365
Loss from operations | (42,485) | (33,871)
Interest expense | (1,588) | (1,649)
Interest and other income, net | 530 | 637
Consolidated net loss before taxes | (43,543) | (34,883)
Deferred tax benefit | (8,652) | 0
Net loss | $ (34,891) | $ (34,883)
Net loss per common share, basic and diluted | $ (0.33) | $ (0.34)
Shares used in computing consolidated net loss per common share, basic and diluted | 104,461 | 103,682
Unrealized gain (loss) on investments | $ (69) | $ 516
Comprehensive loss | $ (34,960) | $ (34,367)

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- Definition This item represents the change in fair value of the Symphony Icon, Inc. purchase liability. In connection with the acquisition of Symphony Icon, Lexicon made an initial estimate of the fair value of the liability for the associated based and contingent payments. Changes in this liability, based on the development of the programs and the time until such payments are expected to be made, are recorded in Lexicon's consolidated statements of operations. + References No definition available. + Details
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- Definition Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Other Comprehensive Income -URI http://asc.fasb.org/extlink&oid=51831270 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Comprehensive Income -URI http://asc.fasb.org/extlink&oid=51831223 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=66004124&loc=d3e557-108580 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Net Income -URI http://asc.fasb.org/extlink&oid=51831255 + Details
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