<SEC-DOCUMENT>0001062822-17-000048-index.html : 20170915
<SEC-HEADER>0001062822-17-000048.hdr.sgml : 20170915
<ACCEPTANCE-DATETIME>20170915172202
ACCESSION NUMBER:		0001062822-17-000048
CONFORMED SUBMISSION TYPE:	S-3ASR
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20170915
DATE AS OF CHANGE:		20170915
EFFECTIVENESS DATE:		20170915

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3ASR
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-220492
		FILM NUMBER:		171088634

	BUSINESS ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON PHARMACEUTICALS, INC./DE
		DATE OF NAME CHANGE:	20070426

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3ASR
<SEQUENCE>1
<FILENAME>forms-3universalshelfsepte.htm
<DESCRIPTION>FORM S-3
<TEXT>
Document 1 - file: forms-3universalshelfsepte.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.13
<SEQUENCE>2
<FILENAME>exh413-formofindenture.htm
<DESCRIPTION>FORM OF INDENTURE
<TEXT>
Document 2 - file: exh413-formofindenture.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>copyofexh51opinionofvinson.htm
<DESCRIPTION>VE OPINION (S-3 2017)
<TEXT>
Document 3 - file: copyofexh51opinionofvinson.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-12.1
<SEQUENCE>4
<FILENAME>exh121-statementofcomputat.htm
<DESCRIPTION>STATEMENT OF COMPUTATION (S-3 2017)
<TEXT>
Document 4 - file: exh121-statementofcomputat.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>5
<FILENAME>exh231-consentofindependen.htm
<DESCRIPTION>EY CONSENT (S-3 2017)
<TEXT>
Document 5 - file: exh231-consentofindependen.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>logoa04.jpg
<TEXT>
Document 6 - file: logoa04.jpg

</DOCUMENT>
</SEC-DOCUMENT>