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Summary of Significant Accounting Policies Segment Information and Signficant Customers (Details)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Segment Information and Significant Customers [Abstract]      
Entity Wide Revenue Sanofi Percentage 64.00% 90.00% 98.00%
Entity Wide Revenue Ipsen Percentage 18.00% 9.00%