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Cash and Cash Equivalents and Investments (Details 1) - USD ($)
$ in Thousands
Mar. 31, 2018
Dec. 31, 2017
Cash and Cash Equivalents    
Fair Value    
Amortized Cost $ 20,421 $ 61,661
Gross Unrealized Gains 0 0
Gross Unrealized Losses 0 0
Estimated Fair Value 20,421 61,661
U.S. Treasury Securities    
Fair Value    
Amortized Cost 214,302 222,316
Gross Unrealized Gains 0 0
Gross Unrealized Losses (317) (168)
Estimated Fair Value 213,985 222,148
Corporate Debt Securities    
Fair Value    
Amortized Cost 27,943 27,033
Gross Unrealized Gains 0 0
Gross Unrealized Losses (77) (54)
Estimated Fair Value 27,866 26,979
Total Short-term Investments    
Fair Value    
Amortized Cost 242,245 249,349
Gross Unrealized Gains 0 0
Gross Unrealized Losses (394) (222)
Estimated Fair Value 241,851 249,127
Total Cash and Cash Equivalents and Investments    
Fair Value    
Amortized Cost 262,666 311,010
Gross Unrealized Gains 0 0
Gross Unrealized Losses (394) (222)
Estimated Fair Value $ 262,272 $ 310,788