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Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017
Revenues: |  |  |  |
Net product revenue | $ 7,316 | $ 3,892 | $ 12,776 | $ 4,613
Collaborative agreements | 6,359 | 8,104 | 26,024 | 25,669
Royalties and other revenue | 78 | 57 | 160 | 64
Total revenues | 13,753 | 12,053 | 38,960 | 30,346
Operating expenses: |  |  |  |
Cost of sales (including finite-lived intangible asset amortization) | 838 | 537 | 1,371 | 762
Research and development, including stock-based compensation of $1,395, $1,169, $3,050 and $2,353, respectively | 26,589 | 26,934 | 74,372 | 70,515
Increase in fair value of Symphony Icon, Inc. purchase liability | 0 | 0 | 0 | 2,101
Selling, general and administrative expenses, included stock-based compensation of $1,503, $1,234, $2,922 and $2,281, respectively | 16,755 | 18,475 | 31,612 | 33,346
Total operating expenses | 44,182 | 45,946 | 107,355 | 106,724
Loss from operations | (30,429) | (33,893) | (68,395) | (76,378)
Interest expense | (5,187) | (1,614) | (10,301) | (3,202)
Interest and other income, net | 910 | 448 | 1,915 | 978
Net loss before taxes | (34,706) | (35,059) | (76,781) | (78,602)
Income Tax Benefit | 0 | 0 | 0 | (8,652)
Net loss | $ (34,706) | $ (35,059) | $ (76,781) | $ (69,950)
Net loss per common share, basic and diluted | $ (0.33) | $ (0.33) | $ (0.73) | $ (0.67)
Shares used in computing net loss per common share, basic and diluted | 105,848 | 105,300 | 105,758 | 104,883
Unrealized gain (loss) on investments | $ 175 | $ 50 | $ 4 | $ (19)
Comprehensive loss | $ (34,531) | $ (35,009) | $ (76,777) | $ (69,969)

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- Definition This item represents the change in fair value of the Symphony Icon, Inc. purchase liability. In connection with the acquisition of Symphony Icon, Lexicon made an initial estimate of the fair value of the liability for the associated based and contingent payments. Changes in this liability, based on the development of the programs and the time until such payments are expected to be made, are recorded in Lexicon's consolidated statements of operations. + References No definition available. + Details
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- Definition Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=114867106&loc=d3e557-108580 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 1B -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=114867106&loc=SL7669625-108580 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 1A -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=114867106&loc=SL7669619-108580 + Details
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