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Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2018 | Jun. 30, 2017
Cash flows from operating activities: |  |
Net loss | $ (76,781) | $ (69,950)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 1,853 | 1,552
Increase in fair value of Symphony Icon, Inc. purchase liability | 0 | 2,101
Stock-based compensation | 5,972 | 4,634
Amortization of debt issuance costs | 592 | 254
Deferred tax benefit | 0 | (8,652)
Loss on disposal of property and equipment | 0 | (2)
Changes in operating assets and liabilities: |  |
Decrease in accounts receivable | 419 | 2,478
Increase in inventory | (194) | (811)
(Increase) decrease in prepaid expenses and other current assets | 481 | (6,296)
Decrease in other assets | 0 | 33
Decrease in accounts payable and other liabilities | (6,644) | (22,269)
Decrease in deferred revenue | (24,996) | (20,797)
Net cash used in operating activities | (99,298) | (117,721)
Cash flows from investing activities: |  |
Purchases of property and equipment | (55) | (163)
Purchases of investments | (49,638) | (59,989)
Maturities of investments | 104,123 | 159,393
Net cash provided by investing activities | 54,430 | 99,241
Cash flows from financing activities: |  |
Proceeds from issuance of common stock | 392 | 5,427
Repurchase of common stock | (972) | (1,679)
Repayment of debt borrowings | (1,169) | (1,162)
Net cash (used in) provided by financing activities | (1,749) | 2,586
Net decrease in cash and cash equivalents | (46,617) | (15,894)
Cash and cash equivalents at beginning of period | 61,661 | 46,600
Cash and cash equivalents at end of period | 15,044 | 30,706
Supplemental disclosure of cash flow information: |  |
Cash paid for interest | 6,726 | 2,956
Supplemental disclosure of non-cash investing and financing activities: |  |
Common stock issued in satisfaction of Symphony Icon payment obligation | 0 | 10,499
Unrealized loss on investments | 4 | (19)
Accumulated Deficit |  |
Cash flows from operating activities: |  |
Net loss | $ (76,781) | (69,950)
Supplemental disclosure of non-cash investing and financing activities: |  |
Common stock issued in satisfaction of Symphony Icon payment obligation |  | $ 0

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- Definition This item represents the change in fair value of the Symphony Icon, Inc. purchase liability. In connection with the acquisition of Symphony Icon, Lexicon made an initial estimate of the fair value of the liability for the associated based and contingent payments. Changes in this liability, based on the development of the programs and the time until such payments are expected to be made, are recorded in Lexicon's consolidated statements of operations. + References No definition available. + Details
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- Definition On July 30, 2010, Lexicon entered into an Amended and Restated Purchase Option Agreement with Symphony Icon and Holdings and simultaneously exercised the Purchase Option, thereby reacquiring the Programs. Pursuant to the amended terms of the Purchase Option, Lexicon paid Holdings $10 million and issued 13,237,591 shares of common stock to designees of Holdings on July 30, 2012 in satisfaction of an additional $35 million base payment obligation. Lexicon also agreed to make up to $45 million in additional payments, which will consist of 50% of any consideration Lexicon receives pursuant to any licensing transaction under which Lexicon grants a third party rights to commercialize LX1032, LX1033 or other pharmaceutical compositions modulating the same target as those drug candidates. This represents the shares issued to designees of Holdings during the period. + References No definition available. + Details
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