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Summary of Significant Accounting Policies - Correction of errors in previously reported consolidated financial statements (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2018 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Error Corrections and Prior Period Adjustments Restatement [Line Items] |  |  |  |  |  |  |  |  |  |  |
Net loss | $ (16,781) | $ (27,396) | $ (34,549) | $ (41,822) | $ (26,609) | $ (29,809) | $ (34,657) | $ (31,918) | $ (120,548) | $ (122,993) | $ (131,445)
Accumulated deficit | (1,471,577) |  |  |  | (1,365,241) |  |  |  | (1,471,577) | (1,365,241) |
Adjustments |  |  |  |  |  |  |  |  |  |  |
Error Corrections and Prior Period Adjustments Restatement [Line Items] |  |  |  |  |  |  |  |  |  |  |
Accruals of expenses | $ 19,000 |  |  |  |  |  |  |  | $ 19,000 |  |
Net loss |  | $ 116 | $ 157 | $ 253 | 1,769 | $ 913 | $ 402 | $ 2,973 |  | 6,057 | 9,984
Accumulated deficit |  |  |  |  | 16,163 |  |  |  |  | 16,163 |
Immaterial Errors Related To Research And Development And General And Administrative Expense | Adjustments |  |  |  |  |  |  |  |  |  |  |
Error Corrections and Prior Period Adjustments Restatement [Line Items] |  |  |  |  |  |  |  |  |  |  |
Net loss |  |  |  |  |  |  |  |  |  | 6,100 | 10,000
Accumulated deficit |  |  |  |  | $ 16,100 |  |  |  |  | $ 16,100 | $ 100

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