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v3.19.1

Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2018
Accounting Policies [Abstract] |
Finite-lived Intangible Assets Amortization Expense [Table Text Block] | Estimated future amortization expense for intangible assets as of December 31, 2018 is as follows:
| For the Year Ending December 31
| (in thousands)
2019 | $ | 1,766 |
2020 | 1,766 |
2021 | 1,766 |
2021 | 1,766 |
2023 | 1,766 |
Thereafter | 12,654 |
| $ | 21,484 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions |
| Expected Volatility |  | Risk-free Interest Rate |  | Expected Term |  | Dividend Rate
December 31, 2018: |  |  |  |  |  |  |
Employees | 58% |  | 2.6% |  | 4 |  | 0 | %
Officers and non-employee directors | 63% |  | 2.8% |  | 8 |  | 0 | %
December 31, 2017: |  |  |  |  |  |  |
Employees | 61% |  | 1.7% |  | 4 |  | 0 | %
Officers and non-employee directors | 70% |  | 2.2% |  | 8 |  | 0 | %
December 31, 2016: |  |  |  |  |  |  |
Employees | 63% |  | 1.1% |  | 4 |  | 0 | %
Officers and non-employee directors | 83% |  | 1.6% |  | 8 |  | 0 | %
Schedule of Error Corrections and Prior Period Adjustments | The effects of the corrections of the errors on the Company’s consolidated statements of comprehensive loss and balance sheets are presented in the tables below. The corrections of the errors had no effect on the previously reported total amounts of operating, investing, and financing cash flows on the Company’s consolidated statements of cash flows.
| Years ended December 31,
| 2017 |  | 2016
| Previously reported |  | Adjustments |  | As adjusted |  | Previously reported |  | Adjustments |  | As adjusted
Revenues: |  |  |  |  |  |  |  |  |  |  |
Net product revenue | $ | 15,890 |  |  | $ | — |  |  | $ | 15,890 |  |  | $ | — |  |  | $ | — |  |  | $ | — |
Collaborative agreements | 74,267 |  |  | 1,354 |  |  | 75,621 |  |  | 83,182 |  |  | (4,081 | ) |  | 79,101 |
Royalties and other revenue | 178 |  |  | — |  |  | 178 |  |  | 155 |  |  | — |  |  | 155 |
Total revenues | 90,335 |  |  | 1,354 |  |  | 91,689 |  |  | 83,337 |  |  | (4,081 | ) |  | 79,256 |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |
Cost of sales (including finite-lived intangible asset amortization) | 1,899 |  |  | — |  |  | 1,899 |  |  | — |  |  | — |  |  | — |
Research and development, including stock-based compensation of $4,905 and $3,938, respectively | 156,813 |  |  | (4,590 | ) |  | 152,223 |  |  | 178,151 |  |  | (14,178 | ) |  | 163,973 |
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability | 2,101 |  |  | — |  |  | 2,101 |  |  | (703 | ) |  | — |  |  | (703 | )
Selling, general and administrative, including stock-based compensation of $4,567 and $3,514, respectively | 66,203 |  |  | (113 | ) |  | 66,090 |  |  | 43,044 |  |  | 113 |  |  | 43,157 |
Total operating expenses | 227,016 |  |  | (4,703 | ) |  | 222,313 |  |  | 220,492 |  |  | (14,065 | ) |  | 206,427 |
Loss from operations | (136,681 | ) |  | 6,057 |  |  | (130,624 | ) |  | (137,155 | ) |  | 9,984 |  |  | (127,171 | )
Interest expense | (6,984 | ) |  | — |  |  | (6,984 | ) |  | (6,567 | ) |  | — |  |  | (6,567 | )
Interest and other income, net | 1,954 |  |  | — |  |  | 1,954 |  |  | 2,293 |  |  | — |  |  | 2,293 |
Net loss before taxes | (141,711 | ) |  | 6,057 |  |  | (135,654 | ) |  | (141,429 | ) |  | 9,984 |  |  | (131,445 | )
Income tax benefit | 12,661 |  |  | — |  |  | 12,661 |  |  | — |  |  | — |  |  | — |
Net loss | $ | (129,050 | ) |  | $ | 6,057 |  |  | $ | (122,993 | ) |  | $ | (141,429 | ) |  | $ | 9,984 |  |  | $ | (131,445 | )
Net loss per common share, basic and diluted | $ | (1.23 | ) |  | $ | 0.06 |  |  | $ | (1.17 | ) |  | $ | (1.36 | ) |  | $ | 0.09 |  |  | $ | (1.27 | )
Shares used in computing net loss per common share, basic and diluted | 105,237 |  |  |  |  | 105,237 |  |  | 103,863 |  |  |  |  | 103,863 |
| December 31, 2017
| Previously reported |  | Adjustment |  | As revised
Assets |  |  |  |  |
Current assets: |  |  |  |  |
Cash and cash equivalents | $ | 61,661 |  |  | $ | — |  |  | $ | 61,661 |
Short-term investments | 249,127 |  |  | — |  |  | 249,127 |
Accounts receivable, net of allowances of $4 | 4,825 |  |  | — |  |  | 4,825 |
Inventory | 1,948 |  |  | — |  |  | 1,948 |
Prepaid expenses and other current assets | 4,434 |  |  | — |  |  | 4,434 |
Total current assets | 321,995 |  |  | — |  |  | 321,995 |
Property and equipment, net of accumulated depreciation and amortization of $58,623 | 17,687 |  |  | — |  |  | 17,687 |
Goodwill | 44,543 |  |  | — |  |  | 44,543 |
Other intangible assets | 51,885 |  |  | — |  |  | 51,885 |
Other assets | 429 |  |  | — |  |  | 429 |
Total assets | $ | 436,539 |  |  | $ | — |  |  | $ | 436,539 |
Liabilities and Equity |  |  |  |  |  |
Current liabilities: |  |  |  |  |
Accounts payable | $ | 57,652 |  |  | $ | (18,890 | ) |  | $ | 38,762 |
Accrued liabilities | 12,282 |  |  | — |  |  | 12,282 |
Current portion of deferred revenue | 40,099 |  |  | 252 |  |  | 40,351 |
Current portion of long-term debt, net of deferred financing costs | 14,094 |  |  | — |  |  | 14,094 |
Total current liabilities | 124,127 |  |  | (18,638 | ) |  | 105,489 |
Deferred revenue, net of current portion | 22,428 |  |  | 2,475 |  |  | 24,903 |
Long-term debt, net of deferred financing costs | 231,576 |  |  | — |  |  | 231,576 |
Deferred tax liabilities | 6,014 |  |  | — |  |  | 6,014 |
Other long-term liabilities | 292 |  |  | — |  |  | 292 |
Total liabilities | 384,437 |  |  | (16,163 | ) |  | 368,274 |
Commitments and contingencies |  |  |  |  |  |
Equity: |  |  |  |  |
Preferred stock, $.01 par value; 5,000 shares authorized; no shares issued and outstanding | — |  |  | — |  |  | — |
Common stock, $.001 par value; 225,000 shares authorized; 105,711 shares issued | 106 |  |  | — |  |  | 106 |
Additional paid-in capital | 1,435,526 |  |  | — |  |  | 1,435,526 |
Accumulated deficit | (1,381,404 | ) |  | 16,163 |  |  | (1,365,241 | )
Accumulated other comprehensive loss | (222 | ) |  | — |  |  | (222 | )
Treasury stock, at cost, 122 shares, respectively | (1,904 | ) |  | — |  |  | (1,904 | )
Total (deficit) equity | 52,102 |  |  | 16,163 |  |  | 68,265 |
Total liabilities and (deficit) equity | $ | 436,539 |  |  | $ | — |  |  | $ | 436,539 |
The impact of the error corrections are presented on a “Previously reported,” “Adjustments,” and “As adjusted” basis in the following quarterly financial data for 2017 and 2018 (in thousands, except per share data):
| Three Months Ended March 31, 2018 |  | Three Months Ended March 31, 2017
| Previously reported |  | Adjustments |  | As adjusted |  | Previously reported |  | Adjustments |  | As adjusted
Revenues | $ | 25,207 |  |  | 167 |  |  | $ | 25,374 |  |  | $ | 18,293 |  |  | (331 | ) |  | $ | 17,962 |
Loss from operations | $ | (37,966 | ) |  | 253 |  |  | $ | (37,713 | ) |  | $ | (42,485 | ) |  | 2,973 |  |  | $ | (39,512 | )
Net loss | $ | (42,075 | ) |  | 253 |  |  | $ | (41,822 | ) |  | $ | (34,891 | ) |  | 2,973 |  |  | $ | (31,918 | )
Net loss per common share, basic and diluted | $ | (0.40 | ) |  | — |  |  | $ | (0.40 | ) |  | $ | (0.33 | ) |  | 0.02 |  |  | $ | (0.31 | )
Shares used in computing net loss per common share, basic and diluted | 105,668 |  |  |  |  | 105,668 |  |  | 104,461 |  |  |  |  | 104,461 |
| Three Months Ended June 30, 2018 |  | Three Months Ended June 30, 2017
| Previously reported |  | Adjustments |  | As adjusted |  | Previously reported |  | Adjustments |  | As adjusted
Revenues: | $ | 13,753 |  |  | 45 |  |  | $ | 13,798 |  |  | $ | 12,053 |  |  | 34 |  |  | $ | 12,087 |
Loss from operations | $ | (30,429 | ) |  | 157 |  |  | $ | (30,272 | ) |  | $ | (33,893 | ) |  | 402 |  |  | $ | (33,491 | )
Net loss | $ | (34,706 | ) |  | 157 |  |  | $ | (34,549 | ) |  | $ | (35,059 | ) |  | 402 |  |  | $ | (34,657 | )
Net loss per common share, basic and diluted | $ | (0.33 | ) |  | — |  |  | $ | (0.33 | ) |  | $ | (0.33 | ) |  | — |  |  | $ | (0.33 | )
Shares used in computing net loss per common share, basic and diluted | 105,848 |  |  |  |  | 105,848 |  |  | 105,300 |  |  |  |  | 105,300 |
| Three Months Ended September 30, 2018 |  | Three Months Ended September 30, 2017
| Previously reported |  | Adjustment |  | As adjusted |  | Previously reported |  | Adjustment |  | As adjusted
Revenues: | $ | 6,856 |  |  | 110 |  |  | $ | 6,966 |  |  | $ | 26,942 |  |  | 732 |  |  | $ | 27,674 |
Loss from operations | $ | (23,043 | ) |  | 116 |  |  | $ | (22,927 | ) |  | $ | (29,518 | ) |  | 913 |  |  | $ | (28,605 | )
Net loss | $ | (27,512 | ) |  | 116 |  |  | $ | (27,396 | ) |  | $ | (30,722 | ) |  | 913 |  |  | $ | (29,809 | )
Net loss per common share, basic and diluted | $ | (0.26 | ) |  | — |  |  | $ | (0.26 | ) |  | $ | (0.29 | ) |  | 0.01 |  |  | $ | (0.28 | )
Shares used in computing net loss per common share, basic and diluted | 105,881 |  |  |  |  | 105,881 |  |  | 105,582 |  |  |  |  | 105,582 |
|  |  |  |  |  |  | Three Months Ended December 31, 2017
|  |  |  |  |  |  | Previously reported |  | Adjustment |  | As adjusted
Revenues: |  |  |  |  |  |  | $ | 33,047 |  |  | 919 |  |  | $ | 33,966 |
Loss from operations |  |  |  |  |  |  | $ | (30,785 | ) |  | 1,769 |  |  | $ | (29,016 | )
Net loss |  |  |  |  |  |  | $ | (28,378 | ) |  | 1,769 |  |  | $ | (26,609 | )
Net loss per common share, basic and diluted |  |  |  |  |  |  | $ | (0.27 | ) |  | 0.02 |  |  | $ | (0.25 | )
Shares used in computing net loss per common share, basic and diluted |  |  |  |  |  |  | 105,588 |  |  |  |  | 105,588 |

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