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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2018
Income Taxes [Abstract] |
Schedule of Deferred Tax Assets and Liabilities |
| As of December 31,
| 2018 |  | 2017
| (in thousands)
Deferred tax assets: |  |  |
Net operating loss carryforwards | $ | 206,789 |  |  | $ | 183,839 |
Research and development tax credits | 47,087 |  |  | 46,574 |
Orphan drug credits | 24,524 |  |  | 24,524 |
Capitalized research and development | 71,047 |  |  | 68,603 |
Stock-based compensation | 4,641 |  |  | 3,923 |
Deferred revenue | 5,458 |  |  | 13,523 |
Interest | 3,625 |  |  | — |
Other | 6,044 |  |  | 5,656 |
Total deferred tax assets | 369,215 |  |  | 346,642 |
Deferred tax liabilities: |  |  |
Deferred tax liability related to acquisition of Symphony Icon | (10,525 | ) |  | (10,896 | )
Other | (2 | ) |  | (1 | )
Total deferred tax liabilities | (10,527 | ) |  | (10,897 | )
Less: valuation allowance | (364,702 | ) |  | (341,759 | )
Net deferred tax liabilities | $ | (6,014 | ) |  | $ | (6,014 | )

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- Definition Income Taxes [Abstract] + References No definition available. + Details
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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319 + Details
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