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Property and Equipment (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Aug. 31, 2018 | Dec. 31, 2018 | Dec. 31, 2017
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives | 10 years |  |
Property, Plant and Equipment, Gross |  | $ 75,871 | $ 76,310
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment |  | (60,006) | (58,623)
Property and equipment, net of accumulated depreciation and amortization of $58,623 |  | $ 15,865 | 17,687
Minimum |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives |  | 3 years |
Maximum |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives |  | 40 years |
Computers and Software |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Property, Plant and Equipment, Gross |  | $ 4,557 | 4,605
Computers and Software | Minimum |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives |  | 3 years |
Computers and Software | Maximum |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives |  | 5 years |
Furniture and Fixtures |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Property, Plant and Equipment, Gross |  | $ 5,644 | 6,006
Furniture and Fixtures | Minimum |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives |  | 5 years |
Furniture and Fixtures | Maximum |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives |  | 7 years |
Laboratory Equipment |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Property, Plant and Equipment, Gross |  | $ 3,378 | 3,423
Laboratory Equipment | Minimum |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives |  | 3 years |
Laboratory Equipment | Maximum |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives |  | 7 years |
Leasehold Improvements |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Property, Plant and Equipment, Gross |  | $ 416 | 400
Leasehold Improvements | Minimum |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives |  | 3 years |
Leasehold Improvements | Maximum |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives |  | 7 years |
Buildings |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Property, Plant and Equipment, Gross |  | $ 59,212 | 59,212
Buildings | Minimum |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives |  | 15 years |
Buildings | Maximum |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated Useful Lives |  | 40 years |
Land |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Property, Plant and Equipment, Gross |  | $ 2,664 | $ 2,664

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