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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Income Taxes [Abstract]

Schedule of Deferred Tax Assets and Liabilities

	As of December 31,
	2018				2017
	(in thousands)
Deferred tax assets:
Net operating loss carryforwards	$	206,789			$	183,839
Research and development tax credits	47,087				46,574
Orphan drug credits	24,524				24,524
Capitalized research and development	71,047				68,603
Stock-based compensation	4,641				3,923
Deferred revenue	5,458				13,523
Interest	3,625				—
Other	6,044				5,656
Total deferred tax assets	369,215				346,642
Deferred tax liabilities:
Deferred tax liability related to acquisition of Symphony Icon	(10,525		)		(10,896		)
Other	(2		)		(1		)
Total deferred tax liabilities	(10,527		)		(10,897		)
Less: valuation allowance	(364,702		)		(341,759		)
Net deferred tax liabilities	$	(6,014	)		$	(6,014	)

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- Definition

Income Taxes [Abstract]

+ References

No definition available.

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- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319

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