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Summary of Significant Accounting Policies Segment Information and Signficant Customers (Details) - segment
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Accounting Policies [Abstract]      
Number of operating segments 1    
Entity Wide Revenue Sanofi Percentage 53.00% 66.00% 90.00%
Biologics customer concentration 25.00%    
LXRX Diplomat customer concentration 14.00%    
Entity Wide Revenue Ipsen Percentage   18.00%