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Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Revenues:
Net product revenue	$ 26,583	$ 15,890	$ 0
Collaborative agreements	36,271	75,621	79,101
Royalties and other revenue	355	178	155
Total revenues	63,209	91,689	79,256
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	2,491	1,899	0
Research and development, including stock-based compensation of $6,010, $4,905, and $3,938, respectively	100,243	152,223	163,973
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability	0	2,101	(703)
General and administrative, including stock-based compensation of $5,686, $4,567, and $3,514, respectively	63,754	66,090	43,157
Total operating expenses	166,488	222,313	206,427
Income (loss) from operations	(103,279)	(130,624)	(127,171)
Interest expense	(20,777)	(6,984)	(6,567)
Interest and other income, net	3,508	1,954	2,293
Net loss before taxes	(120,548)	(135,654)	(131,445)
Income tax benefit	0	12,661	0
Net loss	$ (120,548)	$ (122,993)	$ (131,445)
Net loss per common share, basic and diluted (usd per share)	$ (1.14)	$ (1.17)	$ (1.27)
Shares used in computing net loss per common share, basic and diluted	105,830	105,237	103,863
Other comprehensive loss:
Unrealized gain (loss) on investments	$ 210	$ (27)	$ 24
Comprehensive loss	$ (120,338)	$ (123,020)	$ (131,421)

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This item represents the change in fair value of the Symphony Icon, Inc. purchase liability. In connection with the acquisition of Symphony Icon, Lexicon made an initial estimate of the fair value of the liability for the associated based and contingent payments. Changes in this liability, based on the development of the programs and the time until such payments are expected to be made, are recorded in Lexicon's consolidated statements of operations.

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