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Summary of Significant Accounting Policies - Correction of errors in previously reported consolidated financial statements (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Error Corrections and Prior Period Adjustments Restatement [Line Items]
Net loss	$ (16,781)	$ (27,396)	$ (34,549)	$ (41,822)	$ (26,609)	$ (29,809)	$ (34,657)	$ (31,918)	$ (120,548)	$ (122,993)	$ (131,445)
Accumulated deficit	(1,471,577)				(1,365,241)				(1,471,577)	(1,365,241)
Adjustments
Error Corrections and Prior Period Adjustments Restatement [Line Items]
Accruals of expenses	$ 19,000								$ 19,000
Net loss		$ 116	$ 157	$ 253	1,769	$ 913	$ 402	$ 2,973		6,057	9,984
Accumulated deficit					16,163					16,163
Immaterial Errors Related To Research And Development And General And Administrative Expense | Adjustments
Error Corrections and Prior Period Adjustments Restatement [Line Items]
Net loss										6,100	10,000
Accumulated deficit					$ 16,100					$ 16,100	$ 100

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