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Summary of Significant Accounting Policies - Schedule of Error Corrections and Prior Period Adjustments (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenues:                        
Net product revenue                 $ 26,583 $ 15,890 $ 0  
Collaborative agreements                 36,271 75,621 79,101  
Royalties and other revenue                 355 178 155  
Total revenues $ 17,071 $ 6,966 $ 13,798 $ 25,374 $ 33,966 $ 27,674 $ 12,087 $ 17,962 63,209 91,689 79,256  
Operating expenses:                        
Cost of sales (including finite-lived intangible asset amortization)                 2,491 1,899 0  
Research and development, including stock-based compensation of $4,905 and $3,938, respectively                 100,243 152,223 163,973  
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability                 0 2,101 (703)  
Selling, general and administrative, including stock-based compensation of $4,567 and $3,514, respectively                 63,754 66,090 43,157  
Total operating expenses                 166,488 222,313 206,427  
Income (loss) from operations (12,367) (22,927) (30,272) (37,713) (29,016) (28,605) (33,491) (39,512) (103,279) (130,624) (127,171)  
Interest expense                 (20,777) (6,984) (6,567)  
Interest and other income, net                 3,508 1,954 2,293  
Net loss before taxes                 (120,548) (135,654) (131,445)  
Income tax benefit                 0 12,661 0  
Net loss $ (16,781) $ (27,396) $ (34,549) $ (41,822) $ (26,609) $ (29,809) $ (34,657) $ (31,918) $ (120,548) $ (122,993) $ (131,445)  
Net loss per common share, basic and diluted (usd per share) $ (0.16) $ (0.26) $ (0.33) $ (0.40) $ (0.25) $ (0.28) $ (0.33) $ (0.31) $ (1.14) $ (1.17) $ (1.27)  
Shares used in computing net loss per common share, basic and diluted 105,920,000 105,881,000 105,848,000 105,668,000 105,588,000 105,582,000 105,300,000 104,461,000 105,830,000 105,237,000 103,863,000  
Stock-based compensation expense associated with research and development expense                 $ 6,010 $ 4,905 $ 3,938  
Stock-based compensation expense associated with general and administrative expense                 5,686 4,567 3,514  
Current assets:                        
Cash and cash equivalents $ 80,386       $ 61,661       80,386 61,661 46,600 $ 202,989
Short-term investments 79,666       249,127       79,666 249,127    
Accounts receivable, net of allowances of $4 5,924       4,825       5,924 4,825    
Inventory 4,680       1,948       4,680 1,948    
Prepaid expenses and other current assets 2,668       4,434       2,668 4,434    
Total current assets 173,324       321,995       173,324 321,995    
Property and equipment, net of accumulated depreciation and amortization of $58,623 15,865       17,687       15,865 17,687    
Goodwill 44,543       44,543       44,543 44,543    
Other intangible assets 50,119       51,885       50,119 51,885    
Other assets 285       429       285 429    
Total assets 284,136       436,539       284,136 436,539    
Current liabilities:                        
Accounts payable 17,759       38,762       17,759 38,762    
Accrued liabilities 14,482       12,282       14,482 12,282    
Current portion of deferred revenue 3,395       40,351       3,395 40,351    
Current portion of long-term debt, net of deferred financing costs 1,115       14,094       1,115 14,094    
Total current liabilities 36,751       105,489       36,751 105,489    
Deferred revenue, net of current portion 23,651       24,903       23,651 24,903    
Long-term debt, net of deferred financing costs 243,887       231,576       243,887 231,576    
Deferred tax liabilities 6,014       6,014       6,014 6,014    
Other long-term liabilities 238       292       238 292    
Total liabilities 310,541       368,274       310,541 368,274    
Commitments and contingencies                
Equity:                        
Preferred stock, $.01 par value; 5,000 shares authorized; no shares issued and outstanding 0       0       0 0    
Common stock, $.001 par value; 225,000 shares authorized; 105,711 shares issued 106       106       106 106    
Additional paid-in capital 1,447,954       1,435,526       1,447,954 1,435,526    
Accumulated deficit (1,471,577)       (1,365,241)       (1,471,577) (1,365,241)    
Accumulated other comprehensive loss (12)       (222)       (12) (222)    
Treasury stock, at cost, 122 shares, respectively (2,876)       (1,904)       (2,876) (1,904)    
Total (deficit) equity (26,405)       68,265       (26,405) 68,265 167,507 $ 285,972
Total liabilities and (deficit) equity 284,136       436,539       284,136 436,539    
Allowance for doubtful accounts receivable 4       4       4 4    
Accumulated depreciation and amortization, property and equipment $ 60,006       $ 58,623       $ 60,006 $ 58,623    
Preferred stock, par value per share (usd per share) $ 0.01       $ 0.01       $ 0.01 $ 0.01    
Preferred stock, shares authorized 5,000,000       5,000,000       5,000,000 5,000,000    
Preferred stock, shares issued 0       0       0 0    
Preferred stock, shares outstanding 0       0       0 0    
Common stock, par value per share (usd per share) $ 0.001       $ 0.001       $ 0.001 $ 0.001    
Common stock, shares authorized 225,000,000       225,000,000       225,000,000 225,000,000    
Treasury stock, shares 236,000       122,000       236,000 122,000    
Previously reported                        
Revenues:                        
Net product revenue                   $ 15,890 0  
Collaborative agreements                   74,267 83,182  
Royalties and other revenue                   178 155  
Total revenues   $ 6,856 $ 13,753 $ 25,207 $ 33,047 $ 26,942 $ 12,053 $ 18,293   90,335 83,337  
Operating expenses:                        
Cost of sales (including finite-lived intangible asset amortization)                   1,899 0  
Research and development, including stock-based compensation of $4,905 and $3,938, respectively                   156,813 178,151  
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability                   2,101 (703)  
Selling, general and administrative, including stock-based compensation of $4,567 and $3,514, respectively                   66,203 43,044  
Total operating expenses                   227,016 220,492  
Income (loss) from operations   (23,043) (30,429) (37,966) (30,785) (29,518) (33,893) (42,485)   (136,681) (137,155)  
Interest expense                   (6,984) (6,567)  
Interest and other income, net                   1,954 2,293  
Net loss before taxes                   (141,711) (141,429)  
Income tax benefit                   12,661 0  
Net loss   $ (27,512) $ (34,706) $ (42,075) $ (28,378) $ (30,722) $ (35,059) $ (34,891)   $ (129,050) $ (141,429)  
Net loss per common share, basic and diluted (usd per share)   $ (0.26) $ (0.33) $ (0.40) $ (0.27) $ (0.29) $ (0.33) $ (0.33)   $ (1.23) $ (1.36)  
Shares used in computing net loss per common share, basic and diluted   105,881,000 105,848,000 105,668,000 105,588,000 105,582,000 105,300,000 104,461,000   105,237,000 103,863,000  
Stock-based compensation expense associated with research and development expense                   $ 4,905 $ 3,938  
Stock-based compensation expense associated with general and administrative expense                   4,567 3,514  
Current assets:                        
Cash and cash equivalents         $ 61,661         61,661    
Short-term investments         249,127         249,127    
Accounts receivable, net of allowances of $4         4,825         4,825    
Inventory         1,948         1,948    
Prepaid expenses and other current assets         4,434         4,434    
Total current assets         321,995         321,995    
Property and equipment, net of accumulated depreciation and amortization of $58,623         17,687         17,687    
Goodwill         44,543         44,543    
Other intangible assets         51,885         51,885    
Other assets         429         429    
Total assets         436,539         436,539    
Current liabilities:                        
Accounts payable         57,652         57,652    
Accrued liabilities         12,282         12,282    
Current portion of deferred revenue         40,099         40,099    
Current portion of long-term debt, net of deferred financing costs         14,094         14,094    
Total current liabilities         124,127         124,127    
Deferred revenue, net of current portion         22,428         22,428    
Long-term debt, net of deferred financing costs         231,576         231,576    
Deferred tax liabilities         6,014         6,014    
Other long-term liabilities         292         292    
Total liabilities         384,437         384,437    
Commitments and contingencies                    
Equity:                        
Preferred stock, $.01 par value; 5,000 shares authorized; no shares issued and outstanding         0         0    
Common stock, $.001 par value; 225,000 shares authorized; 105,711 shares issued         106         106    
Additional paid-in capital         1,435,526         1,435,526    
Accumulated deficit         (1,381,404)         (1,381,404)    
Accumulated other comprehensive loss         (222)         (222)    
Treasury stock, at cost, 122 shares, respectively         (1,904)         (1,904)    
Total (deficit) equity         52,102         52,102    
Total liabilities and (deficit) equity         $ 436,539         $ 436,539    
Preferred stock, par value per share (usd per share)         $ 0.01         $ 0.01    
Preferred stock, shares authorized         5,000,000         5,000,000    
Preferred stock, shares issued         0         0    
Preferred stock, shares outstanding         0         0    
Common stock, par value per share (usd per share)         $ 0.001         $ 0.001    
Common stock, shares authorized         225,000,000         225,000,000    
Common stock, shares issued         105,711,000         105,711,000    
Treasury stock, shares         122,000         122,000    
Adjustments                        
Revenues:                        
Net product revenue                   $ 0 0  
Collaborative agreements                   1,354 (4,081)  
Royalties and other revenue                   0 0  
Total revenues   $ 110 $ 45 $ 167 $ 919 $ 732 $ 34 $ (331)   1,354 (4,081)  
Operating expenses:                        
Cost of sales (including finite-lived intangible asset amortization)                   0 0  
Research and development, including stock-based compensation of $4,905 and $3,938, respectively                   (4,590) (14,178)  
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability                   0 0  
Selling, general and administrative, including stock-based compensation of $4,567 and $3,514, respectively                   (113) 113  
Total operating expenses                   (4,703) (14,065)  
Income (loss) from operations   116 157 253 1,769 913 402 2,973   6,057 9,984  
Interest expense                   0 0  
Interest and other income, net                   0 0  
Net loss before taxes                   6,057 9,984  
Income tax benefit                   0 0  
Net loss   $ 116 $ 157 $ 253 $ 1,769 $ 913 $ 402 $ 2,973   $ 6,057 $ 9,984  
Net loss per common share, basic and diluted (usd per share)   $ 0.00 $ 0.00 $ 0.00 $ 0.02 $ 0.01 $ 0.00 $ 0.02   $ 0.06 $ 0.09  
Shares used in computing net loss per common share, basic and diluted      
Current assets:                        
Cash and cash equivalents         $ 0         $ 0    
Short-term investments         0         0    
Accounts receivable, net of allowances of $4         0         0    
Inventory         0         0    
Prepaid expenses and other current assets         0         0    
Total current assets         0         0    
Property and equipment, net of accumulated depreciation and amortization of $58,623         0         0    
Goodwill         0         0    
Other intangible assets         0         0    
Other assets         0         0    
Total assets         0         0    
Current liabilities:                        
Accounts payable         (18,890)         (18,890)    
Accrued liabilities         0         0    
Current portion of deferred revenue         252         252    
Current portion of long-term debt, net of deferred financing costs         0         0    
Total current liabilities         (18,638)         (18,638)    
Deferred revenue, net of current portion         2,475         2,475    
Long-term debt, net of deferred financing costs         0         0    
Deferred tax liabilities         0         0    
Other long-term liabilities         0         0    
Total liabilities         (16,163)         (16,163)    
Commitments and contingencies                    
Equity:                        
Preferred stock, $.01 par value; 5,000 shares authorized; no shares issued and outstanding         0         0    
Common stock, $.001 par value; 225,000 shares authorized; 105,711 shares issued         0         0    
Additional paid-in capital         0         0    
Accumulated deficit         16,163         16,163    
Accumulated other comprehensive loss         0         0    
Treasury stock, at cost, 122 shares, respectively         0         0    
Total (deficit) equity         16,163         16,163    
Total liabilities and (deficit) equity         $ 0         $ 0