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Property and Equipment (Details) - USD ($) $ in Thousands	1 Months Ended	12 Months Ended
	Aug. 31, 2018	Dec. 31, 2018	Dec. 31, 2017
Property, Plant and Equipment [Line Items]
Estimated Useful Lives	10 years
Property, Plant and Equipment, Gross		$ 75,871	$ 76,310
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment		(60,006)	(58,623)
Property and equipment, net of accumulated depreciation and amortization of $58,623		$ 15,865	17,687
Minimum
Property, Plant and Equipment [Line Items]
Estimated Useful Lives		3 years
Maximum
Property, Plant and Equipment [Line Items]
Estimated Useful Lives		40 years
Computers and Software
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Gross		$ 4,557	4,605
Computers and Software | Minimum
Property, Plant and Equipment [Line Items]
Estimated Useful Lives		3 years
Computers and Software | Maximum
Property, Plant and Equipment [Line Items]
Estimated Useful Lives		5 years
Furniture and Fixtures
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Gross		$ 5,644	6,006
Furniture and Fixtures | Minimum
Property, Plant and Equipment [Line Items]
Estimated Useful Lives		5 years
Furniture and Fixtures | Maximum
Property, Plant and Equipment [Line Items]
Estimated Useful Lives		7 years
Laboratory Equipment
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Gross		$ 3,378	3,423
Laboratory Equipment | Minimum
Property, Plant and Equipment [Line Items]
Estimated Useful Lives		3 years
Laboratory Equipment | Maximum
Property, Plant and Equipment [Line Items]
Estimated Useful Lives		7 years
Leasehold Improvements
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Gross		$ 416	400
Leasehold Improvements | Minimum
Property, Plant and Equipment [Line Items]
Estimated Useful Lives		3 years
Leasehold Improvements | Maximum
Property, Plant and Equipment [Line Items]
Estimated Useful Lives		7 years
Buildings
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Gross		$ 59,212	59,212
Buildings | Minimum
Property, Plant and Equipment [Line Items]
Estimated Useful Lives		15 years
Buildings | Maximum
Property, Plant and Equipment [Line Items]
Estimated Useful Lives		40 years
Land
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Gross		$ 2,664	$ 2,664

X

- Definition

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 360
-SubTopic 10
-Section 50
-Paragraph 1
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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

+ References

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+ References

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- Definition

Useful life of long lived, physical assets used in the normal conduct of business and not intended for resale, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Examples include, but not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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