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Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Cash flows from operating activities:
Net loss	$ (120,548)	$ (122,993)	$ (131,445)
Adjustments to reconcile consolidated net loss to net cash provided by (used in) operating activities:
Depreciation and amortization	3,683	3,399	2,056
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability	0	2,101	(703)
Stock-based compensation	11,696	9,472	7,452
Loss on disposal of property and equipment	0	3	16
Amortization of debt issuance costs	1,336	599	527
Deferred tax benefit	0	(12,661)	0
Changes in operating assets and liabilities:
(Increase) decrease in accounts receivable	(1,099)	166	(4,080)
Increase in inventories	(2,732)	(1,948)	0
(Increase) decrease in prepaid expenses and other current assets	1,766	(557)	6,259
(Increase) decrease in other assets	144	33	(32)
Increase (decrease) in accounts payable and other liabilities	(18,857)	(11,875)	13,584
Decrease in deferred revenue	(23,996)	(51,133)	(69,262)
Net cash used in operating activities	(148,607)	(185,394)	(175,628)
Cash flows from investing activities:
Purchases of property and equipment	(95)	(228)	(231)
Purchases of investments	(119,987)	(267,873)	(425,673)
Maturities of investments	289,658	318,623	444,156
Net cash provided by investing activities	169,576	50,522	18,252
Cash flows from financing activities:
Proceeds from issuance of common stock, net of fees	732	7,987	3,624
Repurchase of common stock	(972)	(1,679)	(621)
Proceeds from debt borrowings, net of fees	12,529	145,905	0
Repayment of debt borrowings	(14,533)	(2,280)	(2,016)
Net cash provided by (used in) financing activities	(2,244)	149,933	987
Net increase (decrease) in cash and cash equivalents	18,725	15,061	(156,389)
Cash and cash equivalents at beginning of year	61,661	46,600	202,989
Cash and cash equivalents at end of year	80,386	61,661	46,600
Supplemental disclosure of cash flow information:
Cash paid for interest	16,465	5,870	6,050
Supplemental disclosure of noncash investing and financing activities:
Unrealized gain (loss) on investments	210	(27)	24
Common stock issued in satisfaction of Symphony Icon base payment obligation	$ 0		$ 0
Symphony Contingent Payment In Cash		$ 10,499

X

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This item represents the change in fair value of the Symphony Icon, Inc. purchase liability. In connection with the acquisition of Symphony Icon, Lexicon made an initial estimate of the fair value of the liability for the associated based and contingent payments. Changes in this liability, based on the development of the programs and the time until such payments are expected to be made, are recorded in Lexicon's consolidated statements of operations.

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On July 30, 2010, Lexicon entered into an Amended and Restated Purchase Option Agreement with Symphony Icon and Holdings and simultaneously exercised the Purchase Option, thereby reacquiring the Programs. Pursuant to the amended terms of the Purchase Option, Lexicon paid Holdings $10 million and issued 13,237,591 shares of common stock to designees of Holdings on July 30, 2012 in satisfaction of an additional $35 million base payment obligation. Lexicon also agreed to make up to $45 million in additional payments, which will consist of 50% of any consideration Lexicon receives pursuant to any licensing transaction under which Lexicon grants a third party rights to commercialize LX1032, LX1033 or other pharmaceutical compositions modulating the same target as those drug candidates. This represents the shares issued to designees of Holdings during the period.

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