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Consolidated Statements of Comprehensive Income (Loss) (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Revenues:        
Net product revenue $ 8,351 $ 6,286 $ 23,763 $ 19,062
Collaborative agreements 285,910 556 289,209 26,792
Royalties and other revenue 187 124 374 284
Total revenues 294,448 6,966 313,346 46,138
Operating expenses:        
Cost of sales (including finite-lived intangible asset amortization) 577 551 2,457 1,922
Research and development, including stock-based compensation of $1,698, $1,472, $5,369 and $4,522, respectively 26,659 13,763 51,318 87,936
Selling, general and administrative expenses, included stock-based compensation of $1,864, $1,405, $5,370 and $4,327, respectively 13,898 15,579 42,271 47,191
Impairment loss on Intangible Asset 28,638 0 28,638 0
Total operating expenses 69,772 29,893 124,684 137,049
Income (loss) from operations 224,676 (22,927) 188,662 (90,911)
Interest expense (5,204) (5,252) (15,485) (15,552)
Interest and other income, net 600 783 2,080 2,698
Net income (loss) before taxes 220,072 (27,396) 175,257 (103,765)
Income tax benefit (6,014) 0 (6,014) 0
Net income (loss) $ 226,086 $ (27,396) $ 181,271 $ (103,765)
Net income (loss) per common share, Diluted $ 1.95 $ (0.26) $ 1.59 $ (0.98)
Net income (loss) per common share, Basic $ 2.13 $ (0.26) $ 1.71 $ (0.98)
Shares used in computing net income (loss) per common share, Diluted 116,640 105,881 116,742 105,800
Shares used in computing net income loss) per common share, Basic 106,272 105,881 106,200 105,800
Unrealized gain (loss) on investments $ (50) $ 147 $ 48 $ 151
Comprehensive income (loss) $ 226,036 $ (27,249) $ 181,319 $ (103,614)