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Consolidated Statements of Comprehensive Loss-Unaudited - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Revenues:    
Net product revenue $ 7,877 $ 6,740
Collaborative agreements 8 2,439
Royalties and other revenue 114 37
Total revenues 7,999 9,216
Operating expenses:    
Cost of sales (including finite-lived intangible asset amortization) 568 553
Research and development, including stock-based compensation of $2,176 and $1,768, respectively 55,181 12,022
Selling, general and administrative expenses, included stock-based compensation of $2,256 and $1,643, respectively 14,688 14,110
Total operating expenses 70,437 26,685
Loss from operations (62,438) (17,469)
Interest expense (5,131) (5,117)
Interest and other income, net 958 789
Net loss $ (66,611) $ (21,797)
Net loss per common share, Basic and Diluted $ (0.63) $ (0.21)
Shares used in computing net loss per common share, Basic and Diluted 106,536 106,054
Unrealized gain on investments $ 776 $ 45
Comprehensive loss (65,835) (21,752)
Stock-based compensation expense associated with research and development expense 2,176 1,768
Stock-based compensation expense associated with selling, general and administrative expense $ 2,256 $ 1,643