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Summary of Significant Accounting Policies Equity Incentive Awards (Tables) | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2020 | Sep. 30, 2020
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Abstract] |  |
Schedule of Accrued Liabilities | Accrued liabilities: Accrued liabilities consisted of the following:
|  | As of September 30, |  | As of December 31,
|  | 2020 |  | 2019
|  | (in thousands)
Accrued research and development services |  | $ | 50,217 |  |  | $ | 29,033 |
Accrued compensation and benefits |  | 6,023 |  |  | 9,644 |
Short term lease liability |  | 553 |  |  | 553 |
Other |  | 1,704 |  |  | 2,921 |
Accrued liabilities |  | $ | 58,497 |  |  | $ | 42,151 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |  |
|  | Expected Volatility |  | Risk-free Interest Rate |  | Expected Term |  | Dividend Rate
September 30, 2020: |  |  |  |  |  |  |  |
Employees |  | 91 | % |  | 1.3 | % |  | 4 |  | — | %
Officers and non-employee directors |  | 78 | % |  | 1.4 | % |  | 8 |  | — | %
September 30, 2019: |  |  |  |  |  |  |  |
Employees |  | 88 | % |  | 2.2 | % |  | 4 |  | — | %
Officers and non-employee directors |  | 78 | % |  | 2.6 | % |  | 8 |  | — | %
Share-based Payment Arrangement, Option, Activity [Table Text Block] |  |
|  | Options |  | Weighted Average Exercise Price
|  | (in thousands) |  |
Outstanding at December 31, 2019 |  | 7,695 |  |  | $ | 8.95 |
Granted |  | 3,445 |  |  | 3.25 |
Expired |  | (236) |  |  | 12.91 |
Forfeited (1) |  | (1,909) |  |  | 5.71 |
Outstanding at September 30, 2020 |  | 8,995 |  |  | 7.35 |
Exercisable at September 30, 2020 |  | 5,108 |  |  | $ | 9.63 |
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] |  |
|  | Shares |  | Weighted Average Grant Date Fair Value
|  | (in thousands) |  |
Outstanding at December 31, 2019 |  | 2,830 |  |  | $ | 6.35 |
Granted |  | 3,144 |  |  | 3.27 |
Vested |  | (1,219) |  |  | 6.56 |
Forfeited (1) |  | (1,892) |  |  | 4.13 |
Outstanding at September 30, 2020 |  | 2,863 |  |  | $ | 4.35 |

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- Definition Tabular disclosure of the changes in outstanding nonvested restricted stock units. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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