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Commitments and Contingencies (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2020 | Sep. 30, 2020 | Sep. 30, 2019
Commitments and Contingencies Disclosure [Abstract] |  |  |
Sanofi termination cash payment | $ 208,000 | $ 26,000 | $ 208,000
Other Commitments [Line Items] |  |  |
Sanofi termination cash payment | $ 208,000 | 26,000 | $ 208,000
Accounts Receivable [Member] |  |  |
Commitments and Contingencies Disclosure [Abstract] |  |  |
Sanofi termination cash payment |  | 23,200 |
Other Commitments [Line Items] |  |  |
Sanofi termination cash payment |  | $ 23,200 |

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- Definition lxrx_Sanofi termination cash payment - represents the cash payment from Sanofi to terminate the collaboration alliance + References No definition available. + Details
Name: | lxrx_Lxrx_Sanofiterminationcashpayment
Namespace Prefix: | lxrx_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

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- References No definition available. + Details
Name: | us-gaap_CommitmentsAndContingenciesDisclosureAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
Name: | us-gaap_OtherCommitmentsLineItems
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

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- Details
Name: | us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis=us-gaap_AccountsReceivableMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |