<SEC-DOCUMENT>0001127602-20-008956.txt : 20200303
<SEC-HEADER>0001127602-20-008956.hdr.sgml : 20200303
<ACCEPTANCE-DATETIME>20200303161308
ACCESSION NUMBER:		0001127602-20-008956
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20200228
FILED AS OF DATE:		20200303
DATE AS OF CHANGE:		20200303

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MAIN ALAN J
		CENTRAL INDEX KEY:			0001227372

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		20682362

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON PHARMACEUTICALS, INC./DE
		DATE OF NAME CHANGE:	20070426

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
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<TYPE>4
<SEQUENCE>1
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    <periodOfReport>2020-02-28</periodOfReport>

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        <issuerName>LEXICON PHARMACEUTICALS, INC.</issuerName>
        <issuerTradingSymbol>LXRX</issuerTradingSymbol>
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            <rptOwnerName>MAIN ALAN J</rptOwnerName>
        </reportingOwnerId>
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            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>THE WOODLANDS</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>77381</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <officerTitle>EVP, Commercial Supply Ops</officerTitle>
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    <footnotes>
        <footnote id="F1">Each restricted stock unit represents a contingent right to receive one share of common stock.</footnote>
        <footnote id="F2">Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.</footnote>
        <footnote id="F3">Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2017 and vest an additional 25% on February 28 of each of the three succeeding years thereafter.</footnote>
        <footnote id="F4">Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2018 and vest an additional 25% on February 28 of each of the three succeeding years thereafter.</footnote>
        <footnote id="F5">Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.</footnote>
        <footnote id="F6">Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2020 and vest an additional one third on February 28 of each of the two succeeding years thereafter.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Alan J. Main, Ph.D.</signatureName>
        <signatureDate>2020-03-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
