    <SEC-DOCUMENT>0001062822-20-000069-index.html : 20201030
    <SEC-HEADER>0001062822-20-000069.hdr.sgml : 20201030
    <ACCEPTANCE-DATETIME>20201030171109
    ACCESSION NUMBER:		0001062822-20-000069
    CONFORMED SUBMISSION TYPE:	424B5
    PUBLIC DOCUMENT COUNT:		3
    FILED AS OF DATE:		20201030
    DATE AS OF CHANGE:		20201030

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC.
    		CENTRAL INDEX KEY:			0001062822
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				760474169
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		424B5
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-234568
    		FILM NUMBER:		201278229

    	BUSINESS ADDRESS:
    		STREET 1:		8800 TECHNOLOGY FOREST PLACE
    		CITY:			THE WOODLANDS
    		STATE:			TX
    		ZIP:			77381
    		BUSINESS PHONE:		2818633000

    	MAIL ADDRESS:
    		STREET 1:		8800 TECHNOLOGY FOREST PLACE
    		CITY:			THE WOODLANDS
    		STATE:			TX
    		ZIP:			77381

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	LEXICON PHARMACEUTICALS, INC./DE
    		DATE OF NAME CHANGE:	20070426

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
    		DATE OF NAME CHANGE:	20000126
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>424B5
    <SEQUENCE>1
    <FILENAME>prospectussupplementoct202.htm
    <DESCRIPTION>424B5
    <TEXT>
    Document 1 - file: prospectussupplementoct202.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>image_01.jpg
    <TEXT>
    Document 2 - file: image_01.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>lexiconuniversalshelf_imag.jpg
    <TEXT>
    Document 3 - file: lexiconuniversalshelf_imag.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>