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Income Taxes (Details 1) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Deferred Tax Assets and Liabilities |  |  |
Deferred Tax Assets, Operating Loss Carryforwards | $ 201,610 | $ 193,270 |
Deferred Tax Assets, Tax Credit Carryforwards, Research | 29,304 | 46,306 |
Deferred Tax Assets, Tax Credit Carryforwards, Orphan Drug | 24,524 | 24,524 |
Deferred Tax Assets, In Process Research and Development | 47,075 | 58,596 |
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost | 5,651 | 5,340 |
Deferred Tax Assets, Other | 844 | 5,533 |
Deferred Tax Assets, Gross | 309,008 | 333,569 |
Deferred Tax Liability Related to Acquisition of Symphony Icon | 0 | (4,140) |
Deferred Tax Liabilities, Other | 0 | (3) |
Deferred Tax Liabilities, Gross | 0 | (4,143) |
Deferred Tax Assets, Valuation Allowance | (309,008) | (329,426) |
Deferred Tax Liabilities, Net | 0 | 0 |
Income Tax Benefit | 0 | $ (6,014) | $ 0
2020 Federal NOL increase | 38,400 |  |
Decrease in NOLs | (66,900) |  |
R&D Tax Credit Decrease | $ 17,000 |  |

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- Definition On July 30, 2010, Lexicon entered into an Amended and Restated Purchase Option Agreement with Symphony Icon and Holdings and simultaneously exercised the Purchase Option, thereby reacquiring the Programs. Pursuant to the amended terms of the Purchase Option, Lexicon paid Holdings $10 million and issued 13,237,519 shares of common stock to designees of Holdings on July 30, 2012 in satisfaction of an additional $35 million base payment obligation. Lexicon also agreed to make up to $45 million in additional payments, which will consist of 50% of any consideration Lexicon receives pursuant to any licensing transaction under which Lexicon grants a third party rights to commercialize LX1032, LX1033 or other pharmaceutical compositions modulating the same target as those drug candidates. This represents the deferred tax liability relating to the tax impact of future amortization or possible impairments associated with intangible assets acquired with Symphony Icon, which are not deductible for tax purposes. + References No definition available. + Details
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