    <SEC-DOCUMENT>0001062822-21-000051-index.html : 20210806
    <SEC-HEADER>0001062822-21-000051.hdr.sgml : 20210806
    <ACCEPTANCE-DATETIME>20210806160929
    ACCESSION NUMBER:		0001062822-21-000051
    CONFORMED SUBMISSION TYPE:	S-3
    PUBLIC DOCUMENT COUNT:		6
    FILED AS OF DATE:		20210806
    DATE AS OF CHANGE:		20210806

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC.
    		CENTRAL INDEX KEY:			0001062822
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				760474169
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-3
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-258564
    		FILM NUMBER:		211152992

    	BUSINESS ADDRESS:
    		STREET 1:		2445 TECHNOLOGY FOREST BLVD.
    		STREET 2:		SUITE 1100
    		CITY:			THE WOODLANDS
    		STATE:			TX
    		ZIP:			77381
    		BUSINESS PHONE:		2818633000

    	MAIL ADDRESS:
    		STREET 1:		2445 TECHNOLOGY FOREST BLVD.
    		STREET 2:		SUITE 1100
    		CITY:			THE WOODLANDS
    		STATE:			TX
    		ZIP:			77381

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	LEXICON PHARMACEUTICALS, INC./DE
    		DATE OF NAME CHANGE:	20070426

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
    		DATE OF NAME CHANGE:	20000126
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>S-3
    <SEQUENCE>1
    <FILENAME>forms-3registrationstateme.htm
    <DESCRIPTION>S-3
    <TEXT>
    Document 1 - file: forms-3registrationstateme.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.12
    <SEQUENCE>2
    <FILENAME>exh412descriptionofcommons.htm
    <DESCRIPTION>EX-4.12
    <TEXT>
    Document 2 - file: exh412descriptionofcommons.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.14
    <SEQUENCE>3
    <FILENAME>exh414formofindenture.htm
    <DESCRIPTION>EX-4.14
    <TEXT>
    Document 3 - file: exh414formofindenture.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.1
    <SEQUENCE>4
    <FILENAME>exh51veopinion.htm
    <DESCRIPTION>EX-5.1
    <TEXT>
    Document 4 - file: exh51veopinion.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>5
    <FILENAME>exh231consentofey.htm
    <DESCRIPTION>EX-23.1
    <TEXT>
    Document 5 - file: exh231consentofey.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>lexiconuniversalshelf_imag.jpg
    <TEXT>
    Document 6 - file: lexiconuniversalshelf_imag.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>