<SEC-DOCUMENT>0001062822-21-000051-index.html : 20210806
<SEC-HEADER>0001062822-21-000051.hdr.sgml : 20210806
<ACCEPTANCE-DATETIME>20210806160929
ACCESSION NUMBER:		0001062822-21-000051
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20210806
DATE AS OF CHANGE:		20210806

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-258564
		FILM NUMBER:		211152992

	BUSINESS ADDRESS:	
		STREET 1:		2445 TECHNOLOGY FOREST BLVD.
		STREET 2:		SUITE 1100
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		2445 TECHNOLOGY FOREST BLVD.
		STREET 2:		SUITE 1100
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON PHARMACEUTICALS, INC./DE
		DATE OF NAME CHANGE:	20070426

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3
<SEQUENCE>1
<FILENAME>forms-3registrationstateme.htm
<DESCRIPTION>S-3
<TEXT>
Document 1 - file: forms-3registrationstateme.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.12
<SEQUENCE>2
<FILENAME>exh412descriptionofcommons.htm
<DESCRIPTION>EX-4.12
<TEXT>
Document 2 - file: exh412descriptionofcommons.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.14
<SEQUENCE>3
<FILENAME>exh414formofindenture.htm
<DESCRIPTION>EX-4.14
<TEXT>
Document 3 - file: exh414formofindenture.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>4
<FILENAME>exh51veopinion.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 4 - file: exh51veopinion.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>5
<FILENAME>exh231consentofey.htm
<DESCRIPTION>EX-23.1
<TEXT>
Document 5 - file: exh231consentofey.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>lexiconuniversalshelf_imag.jpg
<TEXT>
Document 6 - file: lexiconuniversalshelf_imag.jpg

</DOCUMENT>
</SEC-DOCUMENT>