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v3.22.0.1

Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Revenues: |  |  |
Net product revenue | $ 0 | $ 23,404,000 | $ 32,331,000
Collaborative agreements | 0 | 33,000 | 289,231,000
Royalties and other revenue | 298,000 | 558,000 | 511,000
Total revenues | 298,000 | 23,995,000 | 322,073,000
Operating expenses: |  |  |
Cost of sales (including finite-lived intangible asset amortization) | 0 | 1,929,000 | 3,231,000
Research and development, including stock-based compensation of $4,284, $6,376 and $7,096 respectively | 55,046,000 | 153,621,000 | 91,924,000
Selling, general and administrative, including stock-based compensation of $6,293, $6,898 and $7,122, respectively | 32,342,000 | 47,230,000 | 56,835,000
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill) | 0 | 1,600,000 | 0
Goodwill and Intangible Asset Impairment | 0 | 0 | 28,638,000
Total operating expenses | 87,388,000 | 204,380,000 | 180,628,000
Gain on sale of non-financial assets | 0 | 132,585,000 | 0
Income (loss) from operations | (87,090,000) | (47,800,000) | 141,445,000
Recognition of gain or loss on extinguishment | 0 | 1,003,000 | 0
Interest expense | (802,000) | (14,544,000) | (20,676,000)
Interest and other income, net | 134,000 | 2,767,000 | 3,350,000
Net income (loss) before taxes | (87,758,000) | (58,574,000) | 124,119,000
Income tax benefit | 0 | 0 | 6,014,000
Net income (loss) | (87,758,000) | (58,574,000) | 130,133,000
Other comprehensive loss: |  |  |
Unrealized gain (loss) on investments | (4,000) | (90,000) | 96,000
Comprehensive loss | $ (87,762,000) | $ (58,664,000) | $ 130,229,000
Earnings Per Share, Basic | $ (0.60) | $ (0.53) | $ 1.23
Earnings Per Share, Diluted | $ (0.60) | $ (0.53) | $ 1.16
Weighted Average Number of Shares Outstanding, Diluted | 145,652 | 110,841 | 116,747
Weighted Average Number of Shares Issued, Basic | 145,652 | 110,841 | 106,218

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