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Income Taxes (Details 1) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Deferred Tax Assets and Liabilities |  |  |
Deferred Tax Assets, Operating Loss Carryforwards | $ 229,427 | $ 201,610 |
Deferred Tax Assets, Tax Credit Carryforwards, Research | 29,290 | 29,304 |
Deferred Tax Assets, Tax Credit Carryforwards, Orphan Drug | 24,524 | 24,524 |
Deferred Tax Assets, In Process Research and Development | 36,770 | 47,075 |
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost | 5,163 | 5,651 |
Deferred Tax Assets, Other | 1,308 | 844 |
Deferred Tax Assets, Gross | 326,630 | 309,008 |
Deferred Tax Liabilities, Other | (412) | 0 |
Deferred Tax Liabilities, Gross | (412) | 0 |
Deferred Tax Assets, Valuation Allowance | (326,218) | (309,008) |
Deferred Tax Liabilities, Net | 0 | 0 |
Income Tax Benefit | 0 | 0 | $ (6,014)
2020 Federal NOL increase | 132,700 |  |
Deferred Tax Assets, Section 163j_LXRX | 148 | $ 0 |
Operating Loss Carryforwards, Federal | 1,100,000 |  |
Deferred Tax Assets, Operating Loss Carryforwards, Domestic | $ 342,000 |  |

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