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Consolidated Statements of Stockholders' Equity - USD ($) | Total | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Accumulated Other Comprehensive Gain (Loss) | Treasury Stock
--- | --- | --- | --- | --- | --- | ---
Balance, shares at Dec. 31, 2018 |  | 106,162,000 |  |  |  |
Balance, value at Dec. 31, 2018 | $ (26,405,000) | $ 106,000 | $ 1,447,954,000 | $ (1,471,577,000) | $ (12,000) | $ (2,876,000)
Stock-based compensation | 14,218,000 | $ 0 | 14,218,000 | 0 | 0 | 0
Issuance of common stock under Equity Incentive Plans, shares |  | 517,000 |  |  |  |
Issuance of common stock under Equity Incentive Plans, value | 0 | $ 0 | 0 | 0 | 0 | 0
Repurchase of common stock | (941,000) | 0 | 0 | 0 | 0 | (941,000)
Net loss | 130,133,000 | 0 | 0 | 130,133,000 | 0 | 0
Unrealized gain (loss) on investments | 96,000 | $ 0 | 0 | 0 | 96,000 | 0
Balance, shares at Dec. 31, 2019 |  | 106,679,000 |  |  |  |
Balance, value at Dec. 31, 2019 | 117,101,000 | $ 106,000 | 1,462,172,000 | (1,341,444,000) | 84,000 | (3,817,000)
Stock-based compensation | 13,274,000 | 0 | 13,274,000 | 0 | 0 | 0
Stock Issued During Period, Value, New Issues | 6,963,000 | $ 4,000 | 6,959,000 | 0 | 0 | 0
Stock Issued During Period, Shares, New Issues |  | 3,709,000 |  |  |  |
Sale of Stock, Consideration Received Per Transaction | 63,007,000 | $ 20,000 | 62,987,000 | 0 | 0 | 0
Common stock, shares issued |  | 10,369,000 |  |  |  |
Issuance of common stock under Equity Incentive Plans, shares |  | 1,219,000 |  |  |  |
Issuance of common stock under Equity Incentive Plans, value | 2,000 | $ 2,000 | 0 | 0 | 0 | 0
Repurchase of common stock | (1,026,000) | 0 | 0 | 0 | 0 | (1,026,000)
Net loss | (58,574,000) | 0 | 0 | (58,574,000) | 0 | 0
Unrealized gain (loss) on investments | (90,000) | $ 0 | 0 | 0 | (90,000) | 0
Balance, shares at Dec. 31, 2020 |  | 142,289,000 |  |  |  |
Balance, value at Dec. 31, 2020 | $ 156,371,000 | $ 142,000 | 1,561,096,000 | (1,400,018,000) | (6,000) | (4,843,000)
Sale of Stock, Number of Shares Issued in Transaction | 20,312,500 | 20,313,000 |  |  |  |
Conversion of Stock, Amount Issued | $ 15,714,000 | $ 10,000 | 15,704,000 | 0 | 0 | 0
Proceeds from Nov 2020 ATM Offering | 7,000,000 |  |  |  |  |
Commissions from December 2020 Common Stock Offering | 1,800,000 |  |  |  |  |
Offering expenses from December 20 common stock offering | 200,000 |  |  |  |  |
ATM Offering Total | $ 50,000,000 |  |  |  |  |
Shares Issued, Price Per Share | $ 3.200 |  |  |  |  |
Proceeds from December 2020 common stock offering | $ 63,000,000 |  |  |  |  |
Stock-based compensation | 10,577,000 | 0 | 10,577,000 | 0 | 0 | 0
Stock Issued During Period, Value, New Issues | 35,491,000 | $ 6,000 | 35,485,000 | 0 | 0 | 0
Stock Issued During Period, Shares, New Issues |  | 6,177,000 |  |  |  |
Issuance of common stock under Equity Incentive Plans, shares |  | 1,616,000 |  |  |  |
Issuance of common stock under Equity Incentive Plans, value | 1,593,000 | $ 2,000 | 1,591,000 | 0 | 0 | 0
Repurchase of common stock | (2,675,000) | 0 | 0 | 0 | 0 | (2,675,000)
Net loss | (87,758,000) | 0 | 0 | (87,758,000) | 0 | 0
Unrealized gain (loss) on investments | (4,000) | $ 0 | 0 | 0 | (4,000) | 0
Balance, shares at Dec. 31, 2021 |  | 150,082,000 |  |  |  |
Balance, value at Dec. 31, 2021 | 113,595,000 | $ 150,000 | $ 1,608,749,000 | $ (1,487,776,000) | $ (10,000) | $ (7,518,000)
Share price in November 20 ATM Offering | $ 1.992 |  |  |  |  |
Other Capital Agreements | Other Capital Agreements Common Stock: In December 2020, Lexicon sold 20,312,500 shares of its common stock at a price of $3.200 per share in a registered direct offering pursuant to an existing shelf registration statement. Sale of the shares resulted in net proceeds of $63.0 million, after deducting underwriting discounts and commissions of $1.8 million and offering expenses of $0.2 million. The investors in the offering were Artal International S.C.A., an affiliate of of Invus, L.P., the Company’s largest stockholder, and BVF Partners L.P. and certain affiliates of BVF Partners L.P. All of the net proceeds of the registered direct offering are reflected as issuance of common stock in the accompanying financial statements. In October 2020, Lexicon entered into an Open Market Sale Agreement SM (the “sales agreement”) with Jefferies LLC (“Jefferies”) relating to the shares of its common stock. Lexicon may offer and sell common stock having an aggregate sales price of up to $50,000,000 from time to time through Jefferies acting as its sales agent. In November 2020, Lexicon sold 3,709,233 shares of its common stock at a price of $1.992 per share pursuant to the sales agreement, resulting in net proceeds of $7.0 million. In January 2021, Lexicon sold 2,000,000 shares of its common stock at a price of $8.463 per share pursuant to the sales agreement, resulting in net proceeds of $16.4 million. In August and September 2021, Lexicon sold an aggregate of 4,176,953 shares of its common stock at a price of $4.732 per share pursuant to the sales agreement, resulting in net proceeds of $19.1 million. The net proceeds from each of these sales are reflected as issuances of common stock in the accompanying financial statements. |  |  |  |  |

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