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Summary of Significant Accounting Policies Equity Incentive Awards (Tables) | 3 Months Ended
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Mar. 31, 2022
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Abstract] |
Schedule of Accrued Liabilities | Accrued liabilities: Accrued liabilities consisted of the following:
|  | As of March 31, |  | As of December 31,
|  | 2022 |  | 2021
|  | (in thousands)
Accrued research and development services |  | $ | 5,308 |  |  | $ | 3,669 |
Accrued compensation and benefits |  | 2,616 |  |  | 5,711 |
Short term lease liability |  | 940 |  |  | 1,089 |
Other |  | 720 |  |  | 2,503 |
Total accrued liabilities |  | $ | 9,584 |  |  | $ | 12,972 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Expected Volatility |  | Risk-free Interest Rate |  | Expected Term |  | Dividend Rate
March 31, 2022: |  |  |  |  |  |  |  |
Employees |  | 104 | % |  | 1.8 | % |  | 4 |  | — | %
Officers and non-employee directors |  | 91 | % |  | 1.9 | % |  | 7 |  | — | %
March 31, 2021: |  |  |  |  |  |  |  |
Employees |  | 105 | % |  | 0.4 | % |  | 4 |  | — | %
Officers and non-employee directors |  | 90 | % |  | 1.0 | % |  | 7 |  | — | %
Share-based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Options |  | Weighted Average Exercise Price
|  | (in thousands) |  |
Outstanding at December 31, 2021 |  | 8,367 |  |  | $ | 6.80 |
Granted |  | 3,865 |  |  | 3.18 |
Expired |  | (140) |  |  | 12.60 |
Forfeited |  | (308) |  |  | 9.88 |
Outstanding at March 31, 2022 |  | 11,784 |  |  | 5.46 |
Exercisable at March 31, 2022 |  | 5,093 |  |  | $ | 7.57 |
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] |
|  | Shares |  | Weighted Average Grant Date Fair Value
|  | (in thousands) |  |
Outstanding at December 31, 2021 |  | 1,854 |  |  | $ | 5.16 |
Granted |  | 2,110 |  |  | 2.25 |
Vested |  | (980) |  |  | 4.86 |
Forfeited |  | (35) |  |  | 3.54 |
Outstanding at March 31, 2022 |  | 2,949 |  |  | $ | 3.20 |

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- Definition Tabular disclosure of the changes in outstanding nonvested restricted stock units. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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