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v3.22.4

Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Revenues: |  |  |
Net product revenue | $ 0 | $ 0 | $ 23,404,000
Collaborative agreements | 0 | 0 | 33,000
Royalties and other revenue | 139,000 | 298,000 | 558,000
Total revenues | 139,000 | 298,000 | 23,995,000
Operating expenses: |  |  |
Cost of sales (including finite-lived intangible asset amortization) | 0 | 0 | 1,929,000
Research and development, including stock-based compensation of $4,253, $4,284 and $6,376 respectively | 52,816,000 | 55,046,000 | 153,621,000
Selling, general and administrative, including stock-based compensation of $7,267, $6,293 and $6,898, respectively | 48,083,000 | 32,342,000 | 47,230,000
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill) | 0 | 0 | 1,600,000
Total operating expenses | 100,899,000 | 87,388,000 | 204,380,000
Gain on sale of non-financial assets | 0 | 0 | 132,585,000
Income (loss) from operations | (100,760,000) | (87,090,000) | (47,800,000)
Recognition of gain or loss on extinguishment | 0 | 0 | 1,003,000
Interest expense | (2,780,000) | (802,000) | (14,544,000)
Interest and other income, net | 1,596,000 | 134,000 | 2,767,000
Income tax benefit | 0 | 0 | 0
Net loss | (101,944,000) | (87,758,000) | (58,574,000)
Other comprehensive loss: |  |  |
Unrealized gain (loss) on investments | (418,000) | (4,000) | (90,000)
Comprehensive loss | $ (102,362,000) | $ (87,762,000) | $ (58,664,000)
Earnings Per Share, Basic | $ (0.62) | $ (0.60) | $ (0.53)
Weighted Average Number of Shares Issued, Basic | 165,733 | 145,652 | 110,841

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