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Income Taxes (Details 1) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Deferred Tax Assets and Liabilities |  |  |
Deferred Tax Assets, Operating Loss Carryforwards | $ 251,331 | $ 229,427 |
Deferred Tax Assets, Tax Credit Carryforwards, Research | 29,290 | 29,290 |
Deferred Tax Assets, Tax Credit Carryforwards, Orphan Drug | 24,524 | 24,524 |
Deferred Tax Assets, In Process Research and Development | 33,813 | 36,770 |
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost | 5,445 | 5,163 |
Deferred Tax Assets, Other | 2,255 | 1,308 |
Deferred Tax Assets, Gross | 347,056 | 326,630 |
Deferred Tax Liabilities, Other | (1,295) | (412) |
Deferred Tax Liabilities, Gross | (1,295) | (412) |
Deferred Tax Assets, Valuation Allowance | (345,761) | (326,218) |
Deferred Tax Liabilities, Net | 0 | 0 |
Income Tax Benefit | 0 | 0 | $ 0
2020 Federal NOL increase | 104,000 |  |
Deferred Tax Assets, Section 163j_LXRX | 398 | $ 148 |
Operating Loss Carryforwards, Federal | 1,200,000 |  |
Deferred Tax Assets, Operating Loss Carryforwards, Domestic | $ 446,300 |  |

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