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Debt Obligations - Narrative (Details) - USD ($)
 1 Months Ended 3 Months Ended 12 Months Ended
Aug. 31, 2018
Nov. 30, 2014
Dec. 31, 2022
Dec. 31, 2027
Dec. 31, 2026
Dec. 31, 2025
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Jun. 30, 2022
Mar. 31, 2022
Aug. 30, 2018
Dec. 18, 2017
Debt Instrument                          
Proceeds from Convertible Debt   $ 87,500,000             $ 75,800,000        
Convertible Debt Instrument Interest Rate Stated Percentage     5.25%       5.25%            
Debt instrument, term 2 years                        
Recognition of gain or loss on extinguishment $ 0           $ 0 $ 0 1,003,000        
Estimated useful life of assets 10 years                        
Debt Instrument, Interest Rate, Stated Percentage     7.90%       7.90%            
Debt Instrument, Face Amount                         $ 150,000,000
Convertible Debt               11,600,000          
Convertible Debt Exchange - Total cash consideration                 $ 50,000,000        
2020 Convertible debt exchange - share payment total                 10,368,956        
2020 convertible debt exchange - percentage of principal                 85.00%        
2020 convertible debt exchange - accrued interest                 $ 1,300,000        
Convertible debt exchange                 9,600,000        
Mortgage Debt Interest Rate_Base_Revere_LXRX                       5.50%  
Mortgage Debt Interest Rate BasePlus_Revere_LXRX                       7.50%  
Mortgage Debt Instrument_Revere_LXRX                       $ 12,900,000  
Mortgage Debt Balloon Payment_LXRX                       $ 10,300,000  
Long-Term Debt, Percentage Bearing Fixed Interest, Percentage Rate     8.01%       8.01%            
Term Loan A Warrant Exercise Price     $ 1.95       $ 1.95     $ 2.08      
Subordinated Borrowing, Interest Rate     12.04%                    
Term Loan D Warrant %     0.875%       0.875%            
Term Loan A Final Payment     $ 1,500,000       $ 1,500,000            
Final Payment % with extention     7.00%       7.00%            
Final Payment % with no extention     6.00%       6.00%            
Term Loan A Debt Issuance Costs     $ 350,000       $ 350,000            
Oxford Facility Fee     500,000       500,000            
Term Loan A Net Cash Receipt     24,150,000       24,150,000            
Adjustments to Additional Paid in Capital, Warrant Issued     300,000       700,000            
Interest Expense             2,780,000 $ 802,000 $ 14,544,000        
Term Loan A Debt Discount     $ 4,400,000       $ 4,400,000            
Term Loan C Warrant %     1.75%       1.75%            
Term Loan A Warrants Number     224,128       224,128     420,673      
Term Loan A&B Warrant %     3.50%       3.50%            
Term Loan B     $ 25,000,000       $ 25,000,000            
2026 Oxford Principal Payments         $ 13,000,000                
Oxford Loan Facility     150,000,000       150,000,000            
Oxford Amendment Fee     300,000       300,000            
Term Loan A                     $ 25,000,000    
Term Loan C     50,000,000       50,000,000            
Term Loan D     50,000,000       50,000,000            
Long-term Debt, Gross     48,600,000       48,600,000            
Long-Term Debt, Gross     $ (48,579,000)       $ (48,579,000)            
2027 Oxford Principal Payments A       $ 4,800,000                  
2025 Oxford Principal Payment A           $ 8,700,000              
2025 Oxford Principal Payments B           $ 8,700,000              
2026 Oxford Principal Payments B         $ 13,000,000                
2027 Oxford Principal Payments B       $ 4,800,000                  
Debt, Weighted Average Interest Rate     9.00%       9.00%            
Term Loan B Net Cash Receipt     $ 24,960,000       $ 24,960,000            
Term Loan B Debt Discount     $ 40,000.00       40,000.00            
Interest Expense, Interest-Bearing Liability             $ 2,800,000