<SEC-DOCUMENT>0000899243-23-014464.txt : 20230605
<SEC-HEADER>0000899243-23-014464.hdr.sgml : 20230605
<ACCEPTANCE-DATETIME>20230605164600
ACCESSION NUMBER:		0000899243-23-014464
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20230605
FILED AS OF DATE:		20230605
DATE AS OF CHANGE:		20230605

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Artal Group S.A.
		CENTRAL INDEX KEY:			0001053906
		STATE OF INCORPORATION:			N4

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		23993251

	BUSINESS ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661
		BUSINESS PHONE:		(352) 22.42.59-1

	MAIL ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661

	FORMER NAME:	
		FORMER CONFORMED NAME:	ARTAL GROUP S A
		DATE OF NAME CHANGE:	19980128

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus Public Equities, L.P.
		CENTRAL INDEX KEY:			0001340097

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		23993248

	BUSINESS ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212-317-7520

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

	FORMER NAME:	
		FORMER CONFORMED NAME:	Invus Public Equities, LP
		DATE OF NAME CHANGE:	20050928

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Artal International S.C.A.
		CENTRAL INDEX KEY:			0001218180

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		23993254

	BUSINESS ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661
		BUSINESS PHONE:		352224259-1

	MAIL ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661

	FORMER NAME:	
		FORMER CONFORMED NAME:	ARTAL INTERNATIONAL SCA
		DATE OF NAME CHANGE:	20110531

	FORMER NAME:	
		FORMER CONFORMED NAME:	ARTAL INTERNATIONAL SA
		DATE OF NAME CHANGE:	20030210

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Westend S.A.
		CENTRAL INDEX KEY:			0001283968
		STATE OF INCORPORATION:			N4
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		23993250

	BUSINESS ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661
		BUSINESS PHONE:		3522242591

	MAIL ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661

	FORMER NAME:	
		FORMER CONFORMED NAME:	WESTEND S.A.
		DATE OF NAME CHANGE:	20120816

	FORMER NAME:	
		FORMER CONFORMED NAME:	WESTEND SA
		DATE OF NAME CHANGE:	20040317

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus Public Equities Advisors, LLC
		CENTRAL INDEX KEY:			0001340096

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		23993246

	BUSINESS ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		(212) 371-1717

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Wittouck Amaury
		CENTRAL INDEX KEY:			0001841311

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		23993253

	MAIL ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L2661

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus Advisors, L.L.C.
		CENTRAL INDEX KEY:			0001404553

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		23993245

	BUSINESS ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		(212) 371-1717

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Invus, L.P.
		CENTRAL INDEX KEY:			0001404570

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		23993247

	BUSINESS ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		(212) 371-1717

	MAIL ADDRESS:	
		STREET 1:		C/O THE INVUS GROUP, LLC
		STREET 2:		750 LEXINGTON AVENUE, 30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Stichting Administratiekantoor Westend
		CENTRAL INDEX KEY:			0001460840
		STATE OF INCORPORATION:			XX

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		23993249

	BUSINESS ADDRESS:	
		STREET 1:		CLAUDE DEBUSSYLAAN, 46
		CITY:			AMSTERDAM
		STATE:			P7
		ZIP:			1082 MD
		BUSINESS PHONE:		352-224-2591

	MAIL ADDRESS:	
		STREET 1:		CLAUDE DEBUSSYLAAN, 46
		CITY:			AMSTERDAM
		STATE:			P7
		ZIP:			1082 MD

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Artal International Management S.A.
		CENTRAL INDEX KEY:			0001522131
		STATE OF INCORPORATION:			N4
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30111
		FILM NUMBER:		23993252

	BUSINESS ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661
		BUSINESS PHONE:		352224259-1

	MAIL ADDRESS:	
		STREET 1:		VALLEY PARK
		STREET 2:		44, RUE DE LA VALLEE
		CITY:			LUXEMBOURG
		STATE:			N4
		ZIP:			L-2661

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2445 TECHNOLOGY FOREST BLVD.
		STREET 2:		SUITE 1100
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		2445 TECHNOLOGY FOREST BLVD.
		STREET 2:		SUITE 1100
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON PHARMACEUTICALS, INC./DE
		DATE OF NAME CHANGE:	20070426

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
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<TYPE>4
<SEQUENCE>1
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<DESCRIPTION>FORM 4 SUBMISSION
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<ownershipDocument>

    <schemaVersion>X0407</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2023-06-05</periodOfReport>

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    <issuer>
        <issuerCik>0001062822</issuerCik>
        <issuerName>LEXICON PHARMACEUTICALS, INC.</issuerName>
        <issuerTradingSymbol>LXRX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001218180</rptOwnerCik>
            <rptOwnerName>Artal International S.C.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VALLEY PARK, 44, RUE DE LA VALLEE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
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            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
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            <isOther>0</isOther>
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    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001841311</rptOwnerCik>
            <rptOwnerName>Wittouck Amaury</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VALLEY PARK, 44, RUE DE LA VALLEE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
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            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
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            <isOther>0</isOther>
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    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001522131</rptOwnerCik>
            <rptOwnerName>Artal International Management S.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VALLEY PARK, 44, RUE DE LA VALLEE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2661</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001053906</rptOwnerCik>
            <rptOwnerName>Artal Group S.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VALLEY PARK, 44, RUE DE LA VALLEE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2661</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001283968</rptOwnerCik>
            <rptOwnerName>Westend S.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>VALLEY PARK, 44, RUE DE LA VALLEE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LUXEMBOURG</rptOwnerCity>
            <rptOwnerState>N4</rptOwnerState>
            <rptOwnerZipCode>L-2661</rptOwnerZipCode>
            <rptOwnerStateDescription>LUXEMBOURG</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001460840</rptOwnerCik>
            <rptOwnerName>Stichting Administratiekantoor Westend</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>CLAUDE DEBUSSYLAAN 46</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>AMSTERDAM</rptOwnerCity>
            <rptOwnerState>P7</rptOwnerState>
            <rptOwnerZipCode>1082 MD</rptOwnerZipCode>
            <rptOwnerStateDescription>NETHERLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001340097</rptOwnerCik>
            <rptOwnerName>Invus Public Equities, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>750 LEXINGTON AVENUE, 30TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001404570</rptOwnerCik>
            <rptOwnerName>Invus, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>750 LEXINGTON AVENUE, 30TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
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    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001340096</rptOwnerCik>
            <rptOwnerName>Invus Public Equities Advisors, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>750 LEXINGTON AVENUE, 30TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001404553</rptOwnerCik>
            <rptOwnerName>Invus Advisors, L.L.C.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>750 LEXINGTON AVENUE, 30TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2023-06-05</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>27775050</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>2.60</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>78634381</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F5"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3516214</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F5"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>35402689</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">On May 31, 2023, Artal International S.C.A. entered into a purchase agreement (the &quot;Purchase Agreement&quot;) with the Issuer pursuant to which Artal International S.C.A. agreed to purchase 24,152,218 shares of common stock, $0.001 par value per share (the &quot;Issuer Common Stock&quot;), of the Issuer at a price of $2.60 per share (the &quot;Purchase Price&quot;). The Purchase Agreement also provided Artal International S.C.A. the right to purchase from the Issuer, on a pro rata basis, up to an additional 3,622,832 shares of Issuer Common Stock at a price per share equal to the Purchase Price. On June 1, 2023, pursuant to the 2023 Purchase Agreement, Artal International S.C.A. exercised its right to purchase an additional 3,622,832 shares of Issuer Common Stock at a price per share equal to the Purchase Price. The purchase closed on June 5, 2023.</footnote>
        <footnote id="F2">These securities are directly held by Artal International S.C.A.</footnote>
        <footnote id="F3">These securities are directly held by Invus Public Equities, L.P.</footnote>
        <footnote id="F4">These securities are directly held by Invus, L.P.</footnote>
        <footnote id="F5">Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P., and Invus Advisors, L.L.C. is the general partner of Invus, L.P. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. Artal International S.C.A. is the managing member of Invus Advisors, L.L.C. The managing partner of Artal International S.C.A. is Artal International Management S.A. The sole stockholder of Artal International Management S.A. is Artal Group S.A. The parent company of Artal Group S.A. is Westend S.A. The majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend (the &quot;Stichting&quot;). Mr. Amaury Wittouck is the sole member of the board of the Stichting.</footnote>
        <footnote id="F6">Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the &quot;Exchange Act&quot;), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.</footnote>
    </footnotes>

    <remarks>Invus US Partners LLC directly holds 5,451,204 shares of Issuer Common Stock, which securities are reported on a separate Form 4. For purposes of Section 16 of the Exchange Act, the Reporting Persons may be deemed to be directors by deputization of the Issuer by virtue of Invus, L.P.'s right to designate certain members of the Issuer's board of directors pursuant to a stockholders' agreement between the Issuer and Invus, L.P.</remarks>

    <ownerSignature>
        <signatureName>See Signatures Included in Exhibit 99.1</signatureName>
        <signatureDate>2023-06-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
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<PRE>
                                                                   Exhibit 99.1

This Statement on Form 4 is filed by the Reporting Persons listed below.

Name of Designated Filer: ARTAL INTERNATIONAL S.C.A.

Date of Event Requiring Statement: June 5, 2023.

Issuer Name: Lexicon Pharmaceuticals, Inc. [LXRX]


                                   ARTAL INTERNATIONAL S.C.A.

                                   By: Artal International Management S.A., its
                                       managing partner

                                   By:  /s/ Anne Goffard
                                       -------------------------------
                                       Name: Anne Goffard
                                       Title: Managing Director


                                   ARTAL INTERNATIONAL MANAGEMENT S.A.

                                   By:  /s/ Anne Goffard
                                       -------------------------------
                                       Name: Anne Goffard
                                       Title: Managing Director


                                   ARTAL GROUP S.A.

                                   By:  /s/ Anne Goffard
                                       -------------------------------
                                       Name: Anne Goffard
                                       Title: Authorized Person


                                   WESTEND S.A.

                                   By: /s/ Anne Goffard
                                       -------------------------------
                                       Name: Anne Goffard
                                       Title: Managing Director


                                   STICHTING ADMINISTRATIEKANTOOR
                                   WESTEND

                                   By:  /s/ Amaury Wittouck
                                       --------------------
                                       Name: Amaury Wittouck
                                       Title: Sole Member of the Board


                                   AMAURY WITTOUCK

                                   By: /s/ Amaury Wittouck
                                       -------------------


                                   INVUS, L.P.

                                   By: INVUS ADVISORS, L.L.C., its general
                                       partner

                                   By:    /s/ Raymond Debbane
                                          -------------------
                                   Name:  Raymond Debbane
                                   Title: President


                                   INVUS PUBLIC EQUITIES, L.P.

                                   By: INVUS PUBLIC EQUITIES ADVISORS, LLC, its
                                       general partner

                                   By:    /s/ Raymond Debbane
                                          -------------------
                                   Name:  Raymond Debbane
                                   Title: President


                                   INVUS ADVISORS, L.L.C.

                                   By:    /s/ Raymond Debbane
                                          -------------------
                                   Name:  Raymond Debbane
                                   Title: President


                                   INVUS PUBLIC EQUITIES ADVISORS, LLC

                                   By:    /s/ Raymond Debbane
                                          -------------------
                                   Name:  Raymond Debbane
                                   Title: President
</PRE>
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